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    MATCAP2 microtubule associated tyrosine carboxypeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 23366, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MATCAP2provided by HGNC
    Official Full Name
    microtubule associated tyrosine carboxypeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:22206
    See related
    Ensembl:ENSG00000164542 MIM:619896; AllianceGenome:HGNC:22206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMCP2; KIAA0895
    Summary
    Predicted to enable carboxypeptidase activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 10.8), kidney (RPKM 3.9) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MATCAP2 in Genome Data Viewer
    Location:
    7p14.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (36324152..36390357, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (36465400..36531625, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (36363761..36429966, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18100 Neighboring gene NANOG hESC enhancer GRCh37_chr7:36197697-36198217 Neighboring gene MARK2 pseudogene 7 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36254183-36255020 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36255021-36255856 Neighboring gene endonuclease/exonuclease/phosphatase family domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:36285803-36286305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36297422-36298230 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36298231-36299037 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36320693-36321354 Neighboring gene Sharpr-MPRA regulatory region 9097 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36351141-36351658 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:36399716-36400433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18101 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:36429116-36429706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:36429707-36430297 Neighboring gene anillin, actin binding protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:36544967-36546166 Neighboring gene NFE2L2 motif-containing MPRA enhancer 148 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98398 Neighboring gene acyloxyacyl hydrolase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36655105-36655606 Neighboring gene AOAH intronic transcript 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:36693505-36694049 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:36701053-36701595 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:36802118-36803317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25844 Neighboring gene nucleophosmin 1 pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation. Nicot S, et al. Sci Adv, 2023 Sep 15. PMID 37703372, Free PMC Article
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative tyrosine carboxypeptidase MATCAP2
    Names
    tubulin metallocarboxypeptidase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100425.2 → NP_001093895.1  putative tyrosine carboxypeptidase MATCAP2 isoform 1

      See identical proteins and their annotated locations for NP_001093895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC006960, BC028678, BC056191, BE463421, DB462178
      Consensus CDS
      CCDS43570.1
      UniProtKB/Swiss-Prot
      B4DF35, B7ZLT4, B9EGB9, O94969, Q0VGC1, Q7Z4L2, Q8NCT3
      UniProtKB/TrEMBL
      B4DYR3
      Related
      ENSP00000297063.6, ENST00000297063.10
      Conserved Domains (1) summary
      cl06858
      Location:292 → 507
      DUF1704; Domain of unknown function (DUF1704)

    2. NM_001199706.2 → NP_001186635.1  putative tyrosine carboxypeptidase MATCAP2 isoform 3

      See identical proteins and their annotated locations for NP_001186635.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons from the 5' end and contains an alternate 5' exon and an additional in-frame exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and an additional internal segment, as compared to isoform 1.
      Source sequence(s)
      AC006960, BC144032, BE463421, DC403204
      Consensus CDS
      CCDS56484.1
      UniProtKB/TrEMBL
      B4DYR3
      Related
      ENSP00000390837.1, ENST00000440378.6
      Conserved Domains (1) summary
      cl06858
      Location:202 → 504
      DUF1704; Domain of unknown function (DUF1704)

    3. NM_001199707.2 → NP_001186636.1  putative tyrosine carboxypeptidase MATCAP2 isoform 4

      See identical proteins and their annotated locations for NP_001186636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons from the 5' end and contains an alternate 5' exon, as compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006960, BC056191, BC110422, BE463421
      Consensus CDS
      CCDS56483.1
      UniProtKB/TrEMBL
      B4DYR3
      Related
      ENSP00000344805.5, ENST00000338533.9
      Conserved Domains (1) summary
      cl06858
      Location:279 → 494
      DUF1704; Domain of unknown function (DUF1704)

    4. NM_001199708.2 → NP_001186637.1  putative tyrosine carboxypeptidase MATCAP2 isoform 5

      See identical proteins and their annotated locations for NP_001186637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two exons from the 5' end and contains an alternate 5' exon, which results in a downstream AUG start codon, and has an additional in-frame exon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and an additional internal segment, as compared to isoform 1.
      Source sequence(s)
      AC006960, AK293912, AK302632, BE463421, DC403070
      Consensus CDS
      CCDS56482.1
      UniProtKB/TrEMBL
      B4DYR3
      Related
      ENSP00000389985.1, ENST00000436884.5
      Conserved Domains (1) summary
      cl06858
      Location:102 → 404
      DUF1704; Domain of unknown function (DUF1704)

    5. NM_001300956.2 → NP_001287885.1  putative tyrosine carboxypeptidase MATCAP2 isoform 6

      See identical proteins and their annotated locations for NP_001287885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (6) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006960, BU507941, DC403070
      Consensus CDS
      CCDS75583.1
      UniProtKB/TrEMBL
      B4DYW2, E9PE22
      Related
      ENSP00000390183.1, ENST00000453212.5
      Conserved Domains (1) summary
      cl06858
      Location:43 → 262
      DUF1704; Domain of unknown function (DUF1704)

    6. NM_015314.3 → NP_056129.2  putative tyrosine carboxypeptidase MATCAP2 isoform 2

      See identical proteins and their annotated locations for NP_056129.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons from the 5' end and contains an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB020702, AC006960, BC056191, BE463421, DB060820
      Consensus CDS
      CCDS47573.1
      UniProtKB/TrEMBL
      B4DYR3
      Related
      ENSP00000319251.6, ENST00000317020.10
      Conserved Domains (1) summary
      cl06858
      Location:241 → 456
      DUF1704; Domain of unknown function (DUF1704)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      36324152..36390357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446701.2 → XP_024302469.1  putative tyrosine carboxypeptidase MATCAP2 isoform X2

      UniProtKB/TrEMBL
      B4DYR3
      Conserved Domains (1) summary
      cl06858
      Location:102 → 404
      DUF1704; Domain of unknown function (DUF1704)

    2. XM_024446702.2 → XP_024302470.1  putative tyrosine carboxypeptidase MATCAP2 isoform X3

      Conserved Domains (1) summary
      cl06858
      Location:141 → 356
      DUF1704; Domain of unknown function (DUF1704)

    3. XM_005249690.5 → XP_005249747.1  putative tyrosine carboxypeptidase MATCAP2 isoform X4

      See identical proteins and their annotated locations for XP_005249747.1

      UniProtKB/TrEMBL
      B4DYW2, E9PE22
      Conserved Domains (1) summary
      cl06858
      Location:43 → 262
      DUF1704; Domain of unknown function (DUF1704)

    4. XM_005249689.4 → XP_005249746.1  putative tyrosine carboxypeptidase MATCAP2 isoform X1

      UniProtKB/TrEMBL
      B4DYR3
      Conserved Domains (1) summary
      cl06858
      Location:240 → 542
      DUF1704; Domain of unknown function (DUF1704)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      36465400..36531625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357702.1 → XP_054213677.1  putative tyrosine carboxypeptidase MATCAP2 isoform X2

      UniProtKB/TrEMBL
      B4DYR3

    2. XM_054357703.1 → XP_054213678.1  putative tyrosine carboxypeptidase MATCAP2 isoform X3

    3. XM_054357704.1 → XP_054213679.1  putative tyrosine carboxypeptidase MATCAP2 isoform X4

      UniProtKB/TrEMBL
      B4DYW2, E9PE22

    4. XM_054357701.1 → XP_054213676.1  putative tyrosine carboxypeptidase MATCAP2 isoform X1

      UniProtKB/TrEMBL
      B4DYR3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCT3.4 GenPept UniProtKB/Swiss-Prot:Q8NCT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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