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    DENND11 DENN domain containing 11 [ Homo sapiens (human) ]

    Gene ID: 57189, updated on 10-Dec-2024

    Summary

    Official Symbol
    DENND11provided by HGNC
    Official Full Name
    DENN domain containing 11provided by HGNC
    Primary source
    HGNC:HGNC:29472
    See related
    Ensembl:ENSG00000257093 MIM:620122; AllianceGenome:HGNC:29472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LCHN; PRO2561; KIAA1147
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 17.1), thyroid (RPKM 13.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DENND11 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141656728..141702166, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (142972579..143017998, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141356528..141401966, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18718 Neighboring gene AGK divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141284163-141284720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:141284721-141285276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141285835-141286391 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:141286949-141287505 Neighboring gene acylglycerol kinase Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:141374567-141375546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141391618-141392127 Neighboring gene MPRA-validated peak6798 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:141437175-141438060 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:141447210-141447352 Neighboring gene WEE2 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 82, pseudogene Neighboring gene WEE2 oocyte meiosis inhibiting kinase Neighboring gene single stranded DNA binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DENN domain-containing protein 11
    Names
    predicted protein of HQ2561
    protein LCHN

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080392.2NP_001073861.1  DENN domain-containing protein 11

      See identical proteins and their annotated locations for NP_001073861.1

      Status: VALIDATED

      Source sequence(s)
      AC004918
      Consensus CDS
      CCDS47726.1
      UniProtKB/Swiss-Prot
      A4D1U4, Q9ULS3
      Related
      ENSP00000445768.1, ENST00000536163.6
      Conserved Domains (1) summary
      pfam09804
      Location:80346
      DUF2347; Uncharacterized conserved protein (DUF2347)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      141656728..141702166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315922.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      23320..68761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      142972579..143017998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)