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    Tdrd7 tudor domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 100121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tdrd7provided by MGI
    Official Full Name
    tudor domain containing 7provided by MGI
    Primary source
    MGI:MGI:2140279
    See related
    Ensembl:ENSMUSG00000035517 AllianceGenome:MGI:2140279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCTAIRE2BP; 5730495N10Rik
    Summary
    Predicted to enable mRNA binding activity. Involved in lens fiber cell differentiation; lens morphogenesis in camera-type eye; and spermatogenesis. Acts upstream of or within germ cell development. Located in P granule and chromatoid body. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; eye; germ cell of testis; and olfactory epithelium. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 28.4), placenta adult (RPKM 9.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tdrd7 in Genome Data Viewer
    Location:
    4 B1; 4 24.48 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45965335..46034766)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45965027..46034766)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STARR-seq mESC enhancer starr_10113 Neighboring gene STARR-seq mESC enhancer starr_10114 Neighboring gene STRA6-like Neighboring gene coiled-coil domain containing 180 Neighboring gene tropomodulin 1 Neighboring gene predicted gene, 52729 Neighboring gene STARR-seq mESC enhancer starr_10118 Neighboring gene predicted gene, 54220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis. Chakravarty S, et al. mBio, 2023 Oct 31. PMID 37712680, Free PMC Article
    2. The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication. Subramanian G, et al. J Biol Chem, 2020 May 15. PMID 32273341, Free PMC Article
    3. Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Tanaka T, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670278, Free PMC Article
    4. Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7. Anand D, et al. Front Cell Dev Biol, 2021. PMID 33665188, Free PMC Article
    5. The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. Barnum CE, et al. Hum Mol Genet, 2020 Jul 29. PMID 32420594, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis.
      Title: Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis.
    2. The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
      Title: The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
    3. The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.
      Title: The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.
    4. results identify TRPC3 as a pivotal signaling gateway in Ca(2+)-dependent control of cardiac gene expression
      Title: Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.
    5. Tdrd7 nullizygosity causes cataract and glaucoma and arrest in spermatogenesis;TDRD7 coimmunoprecipitates with specific lens mRNAs; required for posttranscriptional control of mRNAs critical to normal lens development and RNA granule function
      Title: Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.
    6. Tudor-related proteins, which contain multiple repeats of the Tudor domain, constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure
      Title: Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36668

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within germ cell development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lens fiber cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens fiber cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lens fiber cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens morphogenesis in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lens morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatoid body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tudor domain-containing protein 7
    Names
    PCTAIRE2-binding protein
    trap
    tudor repeat associator with PCTAIRE 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290475.1 → NP_001277404.1  tudor domain-containing protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077641, AK150077, BB619178, BC029689, BY427120, CX563409, CX563831, CX568265
      Consensus CDS
      CCDS71381.1
      UniProtKB/TrEMBL
      A0A0A0MQD1
      Related
      ENSMUSP00000103406.3, ENSMUST00000107777.9
      Conserved Domains (5) summary
      cd04508
      Location:728 → 773
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09973
      Location:256 → 322
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:361 → 425
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:38 → 124
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:932 → 1047
      TUDOR; Tudor domain

    2. NM_001355189.1 → NP_001342118.1  tudor domain-containing protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AK161319, BE950089, BY427120, CF736406, CN539534, CX566254
      Consensus CDS
      CCDS18142.1
      UniProtKB/Swiss-Prot
      B1AWG7, B1AWH5, Q8K1H1, Q8R181
      Conserved Domains (4) summary
      cd09973
      Location:223 → 289
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:328 → 392
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:5 → 91
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:903 → 1013
      TUDOR; Tudor domain

    3. NM_146142.2 → NP_666254.1  tudor domain-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_666254.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      BC029689, BY427120, BY783424
      Consensus CDS
      CCDS18142.1
      UniProtKB/Swiss-Prot
      B1AWG7, B1AWH5, Q8K1H1, Q8R181
      Related
      ENSMUSP00000099993.2, ENSMUST00000102929.2
      Conserved Domains (4) summary
      cd09973
      Location:223 → 289
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:328 → 392
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:5 → 91
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:903 → 1013
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45965335..46034766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537518.2 → XP_006537581.1  tudor domain-containing protein 7 isoform X2

      Conserved Domains (4) summary
      cd09973
      Location:256 → 322
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:361 → 425
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:38 → 124
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:676 → 795
      TUDOR; Tudor domain

    2. XM_030253050.2 → XP_030108910.1  tudor domain-containing protein 7 isoform X3

      Conserved Domains (4) summary
      cd09973
      Location:223 → 289
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:328 → 392
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:5 → 91
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:643 → 762
      TUDOR; Tudor domain

    3. XM_030253051.2 → XP_030108911.1  tudor domain-containing protein 7 isoform X4

      Conserved Domains (2) summary
      cd09974
      Location:55 → 119
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:630 → 740
      TUDOR; Tudor domain

    4. XM_030253049.2 → XP_030108909.1  tudor domain-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      B1AWG7, B1AWH5, Q8K1H1, Q8R181
      Conserved Domains (4) summary
      cd09973
      Location:223 → 289
      LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09974
      Location:328 → 392
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      cd09986
      Location:5 → 91
      LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:903 → 1013
      TUDOR; Tudor domain

    5. XM_006537519.2 → XP_006537582.1  tudor domain-containing protein 7 isoform X5

      Conserved Domains (2) summary
      cd09974
      Location:3 → 67
      LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
      pfam00567
      Location:578 → 688
      TUDOR; Tudor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1H1.1 GenPept UniProtKB/Swiss-Prot:Q8K1H1

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