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    CCL17 C-C motif chemokine ligand 17 [ Homo sapiens (human) ]

    Gene ID: 6361, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CCL17provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 17provided by HGNC
    Primary source
    HGNC:HGNC:10615
    See related
    Ensembl:ENSG00000102970 MIM:601520; AllianceGenome:HGNC:10615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TARC; ABCD-2; SCYA17; A-152E5.3
    Summary
    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in appendix (RPKM 2.1), lymph node (RPKM 1.4) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCL17 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57396093..57416063)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63191214..63211239)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57438679..57449975)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57396657-57396838 Neighboring gene C-C motif chemokine ligand 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57412503-57413083 Neighboring gene C-X3-C motif chemokine ligand 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57417624-57418314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57418315-57419004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450029-57450544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450545-57451060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57451577-57452091 Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene coenzyme Q9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Serum TARC levels are strongly correlated with blood eosinophil count in patients with drug eruptions. Komatsu-Fujii T, et al. Allergol Int, 2017 Jan. PMID 27497618
    2. Serum thymus and activation-regulated chemokine level monitoring may predict disease relapse detected by PET scan after reduced-intensity allogeneic stem cell transplantation in patients with Hodgkin lymphoma. Farina L, et al. Biol Blood Marrow Transplant, 2014 Dec. PMID 25240818
    3. Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments. Yasukochi Y, et al. Asian Pac J Allergy Immunol, 2014 Sep. PMID 25268342
    4. Serum chemokine CCL17/thymus activation and regulated chemokine is correlated with coronary artery diseases. Ye Y, et al. Atherosclerosis, 2015 Feb. PMID 25555269
    5. [Association of single nucleotide polymorphisms in TARC/CCL17 gene with Kawasaki disease and its clinical characteristics]. Liu F, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2015 Jul. PMID 26182268

    See all (173) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment.
      Title: Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment.
    2. Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.
      Title: Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.
    3. CCL17/TARC in autoimmunity and inflammation-not just a T-cell chemokine.
      Title: CCL17/TARC in autoimmunity and inflammation-not just a T-cell chemokine.
    4. Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study.
      Title: Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study.
    5. Serum thymus and activation-regulated chemokine is a surrogate marker for bullous pemphigoid disease activity.
      Title: Serum thymus and activation-regulated chemokine is a surrogate marker for bullous pemphigoid disease activity.
    6. CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction.
      Title: CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction.
    7. Serum chemokine CC-motif ligand 17 is a predictive marker of severe COVID-19 in haemodialysis patients: A retrospective observational study.
      Title: Serum chemokine CC-motif ligand 17 is a predictive marker of severe COVID-19 in haemodialysis patients: A retrospective observational study.
    8. IFN-lambda3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.
      Title: IFN-λ3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.
    9. Spatial Transcriptomics Analysis Reveals that CCL17 and CCL22 are Robust Indicators of a Suppressive Immune Environment in Angioimmunoblastic T Cell Lymphoma (AITL).
      Title: Spatial Transcriptomics Analysis Reveals that CCL17 and CCL22 are Robust Indicators of a Suppressive Immune Environment in Angioimmunoblastic T Cell Lymphoma (AITL).
    10. Serum thymus and activation-regulated chemokine (TARC) levels correlate with atopic dermatitis disease severity in patients < 6 months.
      Title: Serum thymus and activation-regulated chemokine (TARC) levels correlate with atopic dermatitis disease severity in patients < 6 months.
    Submit: New GeneRIF Correction See all GeneRIFs (148)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138271, MGC138273

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    		  
    involved_in killing of cells of another organism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C-C motif chemokine 17
    Names
    CC chemokine TARC
    T cell-directed CC chemokine
    chemokine (C-C motif) ligand 17
    small inducible cytokine subfamily A (Cys-Cys), member 17
    small-inducible cytokine A17
    thymus and activation-regulated chemokine

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002987.3 → NP_002978.1  C-C motif chemokine 17 precursor

      See identical proteins and their annotated locations for NP_002978.1

      Status: REVIEWED

      Source sequence(s)
      AC009052, BC069107
      Consensus CDS
      CCDS10780.1
      UniProtKB/Swiss-Prot
      A0N0Q9, Q2M287, Q92583
      Related
      ENSP00000219244.4, ENST00000219244.9
      Conserved Domains (1) summary
      cd00272
      Location:33 → 89
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57396093..57416063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023530.2 → XP_016879019.1  C-C motif chemokine 17 isoform X1

      Conserved Domains (1) summary
      cd00272
      Location:62 → 118
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

    2. XM_011523256.3 → XP_011521558.1  C-C motif chemokine 17 isoform X2

      See identical proteins and their annotated locations for XP_011521558.1

      Conserved Domains (1) summary
      cd00272
      Location:61 → 117
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

    3. XM_047434448.1 → XP_047290404.1  C-C motif chemokine 17 isoform X3

      UniProtKB/Swiss-Prot
      A0N0Q9, Q2M287, Q92583
      Related
      ENSP00000480147.1, ENST00000616880.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63191214..63211239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313597.1 → XP_054169572.1  C-C motif chemokine 17 isoform X1

    2. XM_054313598.1 → XP_054169573.1  C-C motif chemokine 17 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92583.1 GenPept UniProtKB/Swiss-Prot:Q92583

    Gene LinkOut

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