HRP1 Hrp1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HRP1
Official Full Name: Hrp1p
Primary source: SGD:S000005483
Locus tag: YOL123W
See related: AllianceGenome:SGD:S000005483; FungiDB:YOL123W; VEuPathDB:YOL123W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NAB4; NAB5
Summary: Enables mRNA binding activity. Involved in mRNA processing and response to DNA damage checkpoint signaling. Located in cytoplasmic stress granule and nucleus. Part of mRNA cleavage factor complex. Used to study amyotrophic lateral sclerosis type 20; autosomal dominant limb-girdle muscular dystrophy type 3; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; hepatocellular carcinoma; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; muscular dystrophy (multiple); and tropical spastic paraparesis. Orthologous to several human genes including HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B); HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1); and HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HRP1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (87844..89448)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.
Title: Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.
Domains and residues of the Saccharomyces cerevisiae hnRNP protein Hrp1 important for transcriptional autoregulation and noncoding RNA termination.
Title: Domains and residues of the Saccharomyces cerevisiae hnRNP protein Hrp1 important for transcriptional autoregulation and noncoding RNA termination.
RNA polymerase II transcription attenuation at the yeast DNA repair gene DEF1 is biologically significant and dependent on the Hrp1 RNA-recognition motif.
Title: RNA polymerase II transcription attenuation at the yeast DNA repair gene DEF1 is biologically significant and dependent on the Hrp1 RNA-recognition motif.
Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
Title: Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
The NMR structure of the 34 -kDa ternary complex of the RNA recognition motif (RRM) domains of Hrp1 and Rna15 bound to two neighboring elements upstream of the cleavage site
Title: Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1.
PY-NLS-like sequence within Hrp1, which closely matches the PY-NLS consensus, is both necessary and sufficient for nuclear import and is also required for receptor binding and protein function
Title: A PY-NLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1.
Study shows that overexpression of the Hrp1 or Rna14 subunits of the CF IA polyadenylation factor increases recognition of a weakened polyadenylation site.
Title: Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI.
A Nab4-based mechanism mediates alternative 3'pre-messenger RNA processing events and could help control gene expression as part of a physiological response in S. cerevisiae.
Title: Alternative 3' pre-mRNA processing in Saccharomyces cerevisiae is modulated by Nab4/Hrp1 in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in response to DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
part_of mRNA cleavage factor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hrp1p

NP_014518.1

Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

87844..89448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183377.1 → NP_014518.1 TPA: Hrp1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014518.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1U5, Q02741, Q99383

UniProtKB/TrEMBL

A6ZN88, B3LIU3, B5VRD4, C7GV00, G2WMB4, N1NVX5

Conserved Domains (3) summary

TIGR01628
Location:144 → 463

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12330
Location:244 → 321

RRM2_Hrp1p; RNA recognition motif 2 (RRM2) found in yeast nuclear polyadenylated RNA-binding protein 4 (Hrp1p or Nab4p) and similar proteins

cd12577
Location:161 → 236

RRM1_Hrp1p; RNA recognition motif 1 (RRM1) found in yeast nuclear polyadenylated RNA-binding protein 4 (Hrp1p or Nab4p) and similar proteins