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    TPK1 Tpk1p [ Candida albicans SC5314 ]

    Gene ID: 3634879, updated on 30-Nov-2023

    Summary

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    Gene symbol
    TPK1
    Gene description
    Tpk1p
    Locus tag
    CAALFM_C110220CA
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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    Genomic context

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    See TPK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_032089.1 (2255500..2256717, complement)

    Chromosome 1 - NC_032089.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase Neighboring gene uncharacterized protein Neighboring gene bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_032089.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1. Fanning S, et al. Mol Microbiol, 2012 Oct. PMID 22882910, Free PMC Article
    2. Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans. Tao L, et al. PLoS Genet, 2017 Aug. PMID 28787458, Free PMC Article
    3. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Muzzey D, et al. Genome Biol, 2013. PMID 24025428, Free PMC Article
    4. Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. van het Hoog M, et al. Genome Biol, 2007. PMID 17419877, Free PMC Article
    5. The diploid genome sequence of Candida albicans. Jones T, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123810, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tpk1 and Efg1 are required for CO2-induced SFL2 expression.
      Title: Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans.
    2. Tpk1 is required for cell wall integrity and cell adherence.
      Title: Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tpk1p
    XP_723574.1
    • cAMP-dependent protein kinase catalytic subunit; Tpk2 isoform; control of morphogenesis and stress response; WT nuclear localization requires Bcy1; produced during stationary, not exponential growth; rat catheter and Spider biofilm induced

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_032089.1 Reference assembly

      Range
      2255500..2256717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_718481.2 → XP_723574.1  Tpk1p [Candida albicans SC5314]

      See identical proteins and their annotated locations for XP_723574.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H6F207, C4YD23, Q5AP71
      Conserved Domains (1) summary
      cd05580
      Location:91 → 381
      STKc_PKA_like; Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases
    Nucleotide Protein
    Heading Accession and Version

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