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    Mgat1 mannoside acetylglucosaminyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 17308, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mgat1provided by MGI
    Official Full Name
    mannoside acetylglucosaminyltransferase 1provided by MGI
    Primary source
    MGI:MGI:96973
    See related
    Ensembl:ENSMUSG00000020346 AllianceGenome:MGI:96973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mgat-1
    Summary
    Enables acetylglucosaminyltransferase activity. Acts upstream of or within UDP-N-acetylglucosamine catabolic process and in utero embryonic development. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including decidua; early conceptus; embryo ectoderm; embryo endoderm; and retina outer nuclear layer. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 29.2), spleen adult (RPKM 26.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mgat1 in Genome Data Viewer
    Location:
    11 B1.2; 11 29.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49135018..49153854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49244191..49263027)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 62 Neighboring gene predicted gene, 18583 Neighboring gene STARR-positive B cell enhancer ABC_E6976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49057557-49057744 Neighboring gene predicted gene, 51893 Neighboring gene STARR-positive B cell enhancer ABC_E195 Neighboring gene STARR-positive B cell enhancer ABC_E8994 Neighboring gene olfactory receptor family 2 subfamily Y member 1G Neighboring gene STARR-seq mESC enhancer starr_29373 Neighboring gene olfactory receptor family 2 subfamily Y member 1F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development. Metzler M, et al. EMBO J, 1994 May 1. PMID 8187759, Free PMC Article
    2. The role of the GlcNAc(beta)1,2Man(alpha)- moiety in mammalian development. Null mutations of the genes encoding UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2 cause embryonic lethality and congenital muscular dystrophy in mice and men, respectively. Schachter H. Biochim Biophys Acta, 2002 Dec 19. PMID 12417411
    3. Oocyte glycoproteins regulate the form and function of the follicle basal lamina and theca cells. Christensen AP, et al. Dev Biol, 2015 May 15. PMID 25557622
    4. Complex N-glycans in Mgat1 null preimplantation embryos arise from maternal Mgat1 RNA. Ioffe E, et al. Glycobiology, 1997 Oct. PMID 9363433
    5. Complex asparagine-linked oligosaccharides in Mgat1-null embryos. Campbell RM, et al. Glycobiology, 1995 Jul. PMID 8563140

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mogat1 is a fasting-induced PPARalpha target gene that may feed forward to regulate liver PPARalpha activity during food deprivation
      Title: Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response.
    2. Mgat1KO provides a model for investigating the relationship between systemic reductions in glycosylation and cardiac disease, showing that clinically relevant changes in cardiomyocyte hybrid/complex N-glycosylation are sufficient to cause DCM and early death
      Title: Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy.
    3. MGAT1 activity may play a role in regulating basal adipocyte FFA retention
      Title: Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.
    4. MGAT1 is required to regulate ERK1/2 signaling during spermatogenesis, potentially via different mechanisms.
      Title: MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis.
    5. The MGAT1 interacts with DGAT2, which serves to synergistically increase the TAG biosynthesis and LD expansion, leading to enhancement of lipid accumulation in the liver and fat.
      Title: Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis.
    6. this study shows that loss of O-GlcNAc transferase blocks T cell progenitor renewal, malignant transformation and peripheral T cell clonal expansion
      Title: Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.
    7. Inhibition of hepatic Mogat1 improves hepatic metabolic abnormalities without attenuating liver inflammation and injury.
      Title: Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.
    8. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; Mgat1 and C1galt1 are required for embryo development and implantation.
      Title: Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.
    9. analysis of suppression of cancer progression by MGAT1 shRNA knockdown
      Title: Suppression of cancer progression by MGAT1 shRNA knockdown.
    10. the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
      Title: Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-N-acetylglucosamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Names
    GNT-I
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
    glcNAc-T I
    NP_001103618.1
    NP_001103619.1
    NP_001103620.1
    NP_034924.3
    XP_006532461.1
    XP_006532462.1
    XP_006532463.1
    XP_017169803.1
    XP_030101489.1
    XP_030101490.1
    XP_036012268.1
    XP_036012269.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110148.1 → NP_001103618.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001103618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AI118268, AK040121, AL606829, BY088342
      Consensus CDS
      CCDS24602.1
      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Related
      ENSMUSP00000126303.2, ENSMUST00000167400.8
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. NM_001110149.1 → NP_001103619.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001103619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same isoform.
      Source sequence(s)
      AI118268, AK040121
      Consensus CDS
      CCDS24602.1
      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Related
      ENSMUSP00000104817.2, ENSMUST00000109194.2
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. NM_001110150.1 → NP_001103620.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001103620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants encode the same isoform.
      Source sequence(s)
      AI118268, AK004760
      Consensus CDS
      CCDS24602.1
      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Related
      ENSMUSP00000098851.5, ENSMUST00000101293.11
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. NM_010794.3 → NP_034924.3  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_034924.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same isoform.
      Source sequence(s)
      AI118268, AK040121, AL606829, BY088342
      Consensus CDS
      CCDS24602.1
      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Related
      ENSMUSP00000080484.7, ENSMUST00000081794.7
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49135018..49153854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314314.1 → XP_017169803.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_030245629.1 → XP_030101489.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_036156375.1 → XP_036012268.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_006532398.5 → XP_006532461.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006532461.1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    5. XM_030245630.2 → XP_030101490.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    6. XM_006532400.5 → XP_006532463.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006532463.1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    7. XM_036156376.1 → XP_036012269.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    8. XM_006532399.3 → XP_006532462.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006532462.1

      UniProtKB/Swiss-Prot
      P27808
      UniProtKB/TrEMBL
      Q544F0, Q8CIC9
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27808.1 GenPept UniProtKB/Swiss-Prot:P27808

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