Prlr prolactin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prlrprovided by MGI
Official Full Name: prolactin receptorprovided by MGI
Primary source: MGI:MGI:97763
See related: Ensembl:ENSMUSG00000005268 AllianceGenome:MGI:97763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pr-1; Pr-3; Prlr-rs1
Summary: Enables prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and prostate gland growth. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 9.9), liver adult (RPKM 9.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.23 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (10177324..10349276)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (10177238..10349190)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
Title: PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
[Prolactin and its receptor: From animal models to pituitary pathophysiology].
Title: [Prolactin and its receptor: From animal models to pituitary pathophysiology].
Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
Title: Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
Title: The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
Title: Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
Title: Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
Title: The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
Title: Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
Title: Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
Title: Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M22959 (e-PCR)
- UniSTS:124937

px-31f3 (e-PCR)
- UniSTS:257585

Prlr (e-PCR), detects polymorphism
- UniSTS:144264

Prlr (e-PCR), detects polymorphism
- UniSTS:265612

Prlr (e-PCR), detects polymorphism
- UniSTS:516514

Prlr (e-PCR), detects polymorphism
- UniSTS:516515

Prlr (e-PCR), detects polymorphism
- UniSTS:516516

Prlr (e-PCR), detects polymorphism
- UniSTS:516517

Prlr (e-PCR), detects polymorphism
- UniSTS:516518

Prlr (e-PCR), detects polymorphism
- UniSTS:516519

Prlr (e-PCR), detects polymorphism
- UniSTS:516520

C86938 (e-PCR)
- UniSTS:209067

Prlr (e-PCR), detects polymorphism
- UniSTS:516523

BE688741 (e-PCR)
- UniSTS:209068

Prlr (e-PCR), detects polymorphism
- UniSTS:531375

PRLR (e-PCR)
- UniSTS:505783

Prlr (e-PCR), detects polymorphism
- UniSTS:505783

AI987712 (e-PCR)
- UniSTS:164570

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables prolactin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prolactin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prolactin receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of Janus kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lactation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in prolactin signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate gland growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin receptor

Names: PRL-R; prolactin receptor related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253781.1 → NP_001240710.1 prolactin receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001240710.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon and an alternate 3' exon including the coding region and UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK052679, AK054381, BP761592

Consensus CDS

CCDS56976.1

UniProtKB/TrEMBL

G3UVW6, Q8C7G1

Related

ENSMUSP00000121280.2, ENSMUST00000128921.8

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001253782.2 → NP_001240711.1 prolactin receptor isoform 3 precursor

See identical proteins and their annotated locations for NP_001240711.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK052679, M22958

Consensus CDS

CCDS56975.1

UniProtKB/TrEMBL

Q8C7G1

Related

ENSMUSP00000122209.2, ENSMUST00000128450.8

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_011169.5 → NP_035299.4 prolactin receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_035299.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI527408, AK052679, AK054551, AK077980, AK083198, AK087727, AK087749, AK165113, BG087509, DV053280

Consensus CDS

CCDS27377.1

UniProtKB/Swiss-Prot

P15212, P15213, Q08501, Q62099

UniProtKB/TrEMBL

Q99JZ1

Related

ENSMUSP00000122219.2, ENSMUST00000124470.8

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

10177324..10349276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248425.1 → XP_030104285.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

G3UVW6, Q8C7G1

Related

ENSMUSP00000121935.2, ENSMUST00000137867.8

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006520035.1 → XP_006520098.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_006520098.1

UniProtKB/Swiss-Prot

P15212, P15213, Q08501, Q62099

UniProtKB/TrEMBL

Q99JZ1

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006520034.3 → XP_006520097.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_006520097.1

UniProtKB/Swiss-Prot

P15212, P15213, Q08501, Q62099

UniProtKB/TrEMBL

Q99JZ1

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006520038.2 → XP_006520101.1 prolactin receptor isoform X3

See identical proteins and their annotated locations for XP_006520101.1

UniProtKB/TrEMBL

Q8C7G1

Related

ENSMUSP00000118355.2, ENSMUST00000148257.8

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036159267.1 → XP_036015160.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

G3UVW6, Q8C7G1

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006520036.1 → XP_006520099.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_006520099.1

UniProtKB/Swiss-Prot

P15212, P15213, Q08501, Q62099

UniProtKB/TrEMBL

Q99JZ1

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006520037.4 → XP_006520100.1 prolactin receptor isoform X1

See identical proteins and their annotated locations for XP_006520100.1

UniProtKB/Swiss-Prot

P15212, P15213, Q08501, Q62099

UniProtKB/TrEMBL

Q99JZ1

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:18 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

XR_383824.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_045590.1: Suppressed sequence

Description

NR_045590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
NR_045591.1: Suppressed sequence

Description

NR_045591.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
NR_045592.1: Suppressed sequence

Description

NR_045592.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.