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    ZCF32 Zcf32p [ Candida albicans SC5314 ]

    Gene ID: 3635213, updated on 30-Nov-2023

    Summary

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    Gene symbol
    ZCF32
    Gene description
    Zcf32p
    Locus tag
    CAALFM_C304770CA
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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    Genomic context

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    See ZCF32 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_032091.1 (1015233..1017383, complement)

    Chromosome 3 - NC_032091.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative DNA/RNA helicase Neighboring gene uncharacterized protein Neighboring gene RBR-type E3 ubiquitin transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_032091.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZCF32, a fungus specific Zn(II)2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans. Kakade P, et al. Sci Rep, 2016 Aug 8. PMID 27498700, Free PMC Article
    2. Two negative regulators of biofilm development exhibit functional divergence in conferring virulence potential to Candida albicans. Kakade P, et al. FEMS Yeast Res, 2019 Mar 1. PMID 30052909
    3. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Muzzey D, et al. Genome Biol, 2013. PMID 24025428, Free PMC Article
    4. Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. van het Hoog M, et al. Genome Biol, 2007. PMID 17419877, Free PMC Article
    5. The diploid genome sequence of Candida albicans. Jones T, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123810, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. While acting as negative regulators of biofilm formation, transcription factors Zcf32 and Upc2 target a different set of biofilm genes. A mouse model of candidiasis reveals that zcf32/zcf32 was hypervirulent, while upc2/upc2 shows compromised virulence compared to the wild-type.
      Title: Two negative regulators of biofilm development exhibit functional divergence in conferring virulence potential to Candida albicans.
    2. the transcription factor ZCF32 negatively regulates biofilm development in C. albicans.
      Title: ZCF32, a fungus specific Zn(II)2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zcf32p
    XP_723152.1
    • Predicted Zn(II)2Cys6 transcription factor; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_032091.1 Reference assembly

      Range
      1015233..1017383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_718059.1 → XP_723152.1  Zcf32p [Candida albicans SC5314]

      See identical proteins and their annotated locations for XP_723152.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H6C5M9, C4YQN1, Q5ANG4
      Conserved Domains (2) summary
      cd00067
      Location:9 → 44
      GAL4; GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations
      pfam11951
      Location:290 → 715
      Fungal_trans_2; Fungal specific transcription factor domain
    Nucleotide Protein
    Heading Accession and Version

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