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    Dram2 DNA damage regulated autophagy modulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dram2provided by RGD
    Official Full Name
    DNA damage regulated autophagy modulator 2provided by RGD
    Primary source
    RGD:1564099
    See related
    EnsemblRapid:ENSRNOG00000017744 AllianceGenome:RGD:1564099
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem77
    Summary
    Predicted to be involved in photoreceptor cell maintenance; regulation of autophagy; and visual perception. Predicted to act upstream of or within cell population proliferation and retina development in camera-type eye. Predicted to be located in Golgi apparatus; apical plasma membrane; and photoreceptor inner segment. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in cone-rod dystrophy 21. Orthologous to human DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 374.1), Liver (RPKM 292.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dram2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196724052..196752645)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (194035624..194064415)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (209160901..209189641)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 9 Neighboring gene uncharacterized LOC100912312 Neighboring gene DENN domain containing 2D Neighboring gene choline/ethanolamine phosphotransferase 1 Neighboring gene uncharacterized LOC134485947 Neighboring gene uncharacterized LOC120100909 Neighboring gene ligand dependent nuclear receptor interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. El-Asrag ME, et al. Am J Hum Genet, 2015 Jun 4. PMID 25983245, Free PMC Article
    2. Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death. Park SM, et al. Biochem Biophys Res Commun, 2009 Dec 25. PMID 19895784
    3. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. O'Prey J, et al. Cell Cycle, 2009 Jul 15. PMID 19556885
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109061

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA damage-regulated autophagy modulator protein 2
    Names
    transmembrane protein 77

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025018.1 → NP_001020189.1  DNA damage-regulated autophagy modulator protein 2

      See identical proteins and their annotated locations for NP_001020189.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091251
      UniProtKB/Swiss-Prot
      Q5BK09
      UniProtKB/TrEMBL
      A6HUQ7
      Related
      ENSRNOP00000023903.5, ENSRNOT00000023903.9
      Conserved Domains (1) summary
      pfam10277
      Location:7 → 233
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196724052..196752645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233123.5 → XP_006233185.1  DNA damage-regulated autophagy modulator protein 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:7 → 200
      Frag1; Frag1/DRAM/Sfk1 family

    2. XM_063282175.1 → XP_063138245.1  DNA damage-regulated autophagy modulator protein 2 isoform X2

    3. XM_063282176.1 → XP_063138246.1  DNA damage-regulated autophagy modulator protein 2 isoform X3

    4. XM_039102706.2 → XP_038958634.1  DNA damage-regulated autophagy modulator protein 2 isoform X3

      Conserved Domains (1) summary
      pfam10277
      Location:1 → 103
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK09.1 GenPept UniProtKB/Swiss-Prot:Q5BK09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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