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    Med15 mediator complex subunit 15 [ Mus musculus (house mouse) ]

    Gene ID: 94112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med15provided by MGI
    Official Full Name
    mediator complex subunit 15provided by MGI
    Primary source
    MGI:MGI:2137379
    See related
    Ensembl:ENSMUSG00000012114 AllianceGenome:MGI:2137379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcqap; mPcqap; A230074L19Rik
    Summary
    Predicted to enable transcription coregulator activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; limb; and limb bud. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 37.3), small intestine adult (RPKM 28.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med15 in Genome Data Viewer
    Location:
    16 A3; 16 10.94 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17469072..17540811, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17651208..17722947, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17619324-17619507 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene STARR-seq mESC enhancer starr_40259 Neighboring gene coiled-coil domain containing 74A Neighboring gene calcyclin binding protein pseudogene Neighboring gene ribosomal protein L26, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E5529 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 8 Neighboring gene biorientation of chromosomes in cell division 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. Berti L, et al. Genomics, 2001 Jun 15. PMID 11414760
    2. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
    3. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Maynard TM, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14614146, Free PMC Article
    4. Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Kolonay DW, et al. Front Cell Dev Biol, 2024. PMID 38690566, Free PMC Article
    5. Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration. Li X, et al. Life Sci, 2023 May 1. PMID 36878279

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 15
    Names
    PC2 glutamine/Q-rich-associated protein
    positive cofactor 2 glutamine/Q-rich-associated protein
    positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040683.2 → NP_001035773.1  mediator of RNA polymerase II transcription subunit 15 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC087802, AC115733, AK131186
      Consensus CDS
      CCDS37273.1
      UniProtKB/TrEMBL
      E9Q7C1, Q6KAM1
      Related
      ENSMUSP00000079737.7, ENSMUST00000080936.14
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 745
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. NM_001285884.1 → NP_001272813.1  mediator of RNA polymerase II transcription subunit 15 isoform c

      See identical proteins and their annotated locations for NP_001272813.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC087802, AC115733
      Consensus CDS
      CCDS88892.1
      UniProtKB/TrEMBL
      Q3TE00, Q6KAM1
      Related
      ENSMUSP00000156291.2, ENSMUST00000232236.2
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 762
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. NM_001285886.1 → NP_001272815.1  mediator of RNA polymerase II transcription subunit 15 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences. These differences result in the use of a alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087802, AC115733
      Consensus CDS
      CCDS88891.1
      UniProtKB/TrEMBL
      A0A338P730, Q3TLG6
      Related
      ENSMUSP00000156242.2, ENSMUST00000232645.2
      Conserved Domains (1) summary
      pfam09606
      Location:259 → 635
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    4. NM_001358404.1 → NP_001345333.1  mediator of RNA polymerase II transcription subunit 15 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform e, which is shorter than isoform a.
      Source sequence(s)
      AC087802, AC115733
      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 714
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    5. NM_033609.3 → NP_291087.2  mediator of RNA polymerase II transcription subunit 15 isoform a

      See identical proteins and their annotated locations for NP_291087.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC087802, AC115733, AK142224
      Consensus CDS
      CCDS37274.1
      UniProtKB/Swiss-Prot
      G3X8S4, Q924H2
      UniProtKB/TrEMBL
      Q6KAM1
      Related
      ENSMUSP00000012259.8, ENSMUST00000012259.9
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 785
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17469072..17540811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317174.2 → XP_017172663.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 702
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. XM_017317173.2 → XP_017172662.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 742
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. XM_006522783.4 → XP_006522846.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 674
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    4. XM_017317172.3 → XP_017172661.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 775
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    5. XM_017317175.2 → XP_017172664.1  mediator of RNA polymerase II transcription subunit 15 isoform X13

      UniProtKB/TrEMBL
      Q3TLG6
      Conserved Domains (1) summary
      pfam09606
      Location:343 → 631
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    6. XM_036160194.1 → XP_036016087.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

      UniProtKB/TrEMBL
      Q80UN2
      Conserved Domains (1) summary
      pfam09606
      Location:416 → 704
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    7. XM_036160198.1 → XP_036016091.1  mediator of RNA polymerase II transcription subunit 15 isoform X14

      UniProtKB/TrEMBL
      Q80UN2
      Conserved Domains (1) summary
      pfam09606
      Location:296 → 584
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    8. XM_030249350.2 → XP_030105210.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:1 → 676
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    9. XM_006522779.5 → XP_006522842.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:1 → 759
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    10. XM_036160195.1 → XP_036016088.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

      UniProtKB/TrEMBL
      Q80UN2
      Conserved Domains (1) summary
      pfam09606
      Location:416 → 704
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    11. XM_036160197.1 → XP_036016090.1  mediator of RNA polymerase II transcription subunit 15 isoform X12

      UniProtKB/TrEMBL
      Q3TLG6
      Conserved Domains (1) summary
      pfam09606
      Location:360 → 648
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    12. XM_030249349.2 → XP_030105209.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

      UniProtKB/TrEMBL
      Q3TLG6
      Conserved Domains (1) summary
      pfam09606
      Location:1 → 688
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    13. XM_030249346.2 → XP_030105206.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:23 → 784
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    14. XM_030249348.2 → XP_030105208.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

      UniProtKB/TrEMBL
      Q3TLG6
      Conserved Domains (1) summary
      pfam09606
      Location:23 → 713
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    15. XM_036160196.1 → XP_036016089.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

      UniProtKB/TrEMBL
      Q6KAM1
      Conserved Domains (1) summary
      pfam09606
      Location:23 → 701
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RNA

    1. XR_004939258.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924H2.3 GenPept UniProtKB/Swiss-Prot:Q924H2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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