K02C4.3 USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K02C4.3
Official Full Name: USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1
Primary source: WormBase:WBGene00010502
Locus tag: CELE_K02C4.3
See related: AllianceGenome:WB:WBGene00010502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP25 (ubiquitin specific peptidase 25) and USP28 (ubiquitin specific peptidase 28). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K02C4.3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (8080783..8086853, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02C4.3 (e-PCR)
- UniSTS:311360

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1

NP_001309441.1

Confirmed by transcript evidence

NP_001309569.1

Confirmed by transcript evidence

NP_001309570.1

Confirmed by transcript evidence

NP_001309571.1

Confirmed by transcript evidence

NP_001309572.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8080783..8086853 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322743.2 → NP_001309570.1 ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09931

UniProtKB/TrEMBL

A0A131MAU8

Conserved Domains (2) summary

cd02665
Location:169 → 745

Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:169 → 299

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001322741.2 → NP_001309569.1 USP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09931

UniProtKB/TrEMBL

A0A131MAZ4

Conserved Domains (2) summary

cd02665
Location:169 → 745

Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:169 → 299

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001322744.2 → NP_001309441.1 putative ubiquitin carboxyl-terminal hydrolase K02C4.3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09931

Conserved Domains (3) summary

cd02665
Location:169 → 745

Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:169 → 299

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:168 → 744

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_001322742.3 → NP_001309571.1 USP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09931

UniProtKB/TrEMBL

A0A131MBF0

Conserved Domains (2) summary

cd02665
Location:169 → 745

Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:169 → 299

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001322745.3 → NP_001309572.1 putative ubiquitin carboxyl-terminal hydrolase K02C4.3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MCC3