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    ZEB1 zinc finger E-box binding homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 6935, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZEB1provided by HGNC
    Official Full Name
    zinc finger E-box binding homeobox 1provided by HGNC
    Primary source
    HGNC:HGNC:11642
    See related
    Ensembl:ENSG00000148516 MIM:189909; AllianceGenome:HGNC:11642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
    Summary
    This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in endometrium (RPKM 12.8), brain (RPKM 12.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZEB1 in Genome Data Viewer
    Location:
    10p11.22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (31318417..31529804)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (31348155..31559554)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (31607346..31818732)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376481 Neighboring gene uncharacterized LOC105376482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2272 Neighboring gene uncharacterized LOC105376483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435102-31435653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435654-31436204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31498085-31498585 Neighboring gene long intergenic non-protein coding RNA 2664 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:31531588-31532787 Neighboring gene RNA, 5S ribosomal pseudogene 309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2276 Neighboring gene ZEB1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3236 Neighboring gene POM121 transmembrane nucleoporin like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3237 Neighboring gene serine palmitoyltransferase long chain base subunit 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:31756459-31756960 Neighboring gene Sharpr-MPRA regulatory region 3516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3240 Neighboring gene MPRA-validated peak919 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31797084-31797592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31797593-31798099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31873359-31873859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2277 Neighboring gene uncharacterized LOC124906892 Neighboring gene uncharacterized LOC105376484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3241 Neighboring gene glutamate dehydrogenase 1 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZEB1 promotes epithelial-mesenchymal transition in cervical cancer metastasis. Ran J, et al. Fertil Steril, 2015 Jun. PMID 25963537
    2. The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma. Ruh M, et al. J Pathol, 2021 Jun. PMID 33675037
    3. Overexpression of zinc finger E-box binding homeobox factor 1 promotes tumor invasiveness and confers unfavorable prognosis in esophageal squamous cell carcinoma. Yang X, et al. Tumour Biol, 2014 Dec. PMID 25142232
    4. The presence of androgen receptor elements regulates ZEB1 expression in the absence of androgen receptor. Mooney SM, et al. J Cell Biochem, 2015 Jan. PMID 25160502, Free PMC Article
    5. ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway. Li LY, et al. Acta Pharmacol Sin, 2021 Oct. PMID 33514855, Free PMC Article

    See all (656) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCT2 Regulates ZEB1-Induced EMT Gene Transcription to Promote the Metastasis and Tumorigenesis of Papillary Thyroid Carcinoma.
      Title: CCT2 Regulates ZEB1-Induced EMT Gene Transcription to Promote the Metastasis and Tumorigenesis of Papillary Thyroid Carcinoma.
    2. ZEB1 interferes with human periodontal ligament stem cell proliferation and differentiation.
      Title: ZEB1 interferes with human periodontal ligament stem cell proliferation and differentiation.
    3. Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition.
      Title: Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition.
    4. Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
      Title: Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
    5. Correlation of FBXO45 Expression Levels with Cancer Severity by ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer.
      Title: Correlation of FBXO45 Expression Levels with Cancer Severity by ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer.
    6. Endothelial cell specific molecule 1 promotes epithelial-mesenchymal transition of cervical cancer via the E-box binding homeobox 1.
      Title: Endothelial cell specific molecule 1 promotes epithelial-mesenchymal transition of cervical cancer via the E-box binding homeobox 1.
    7. CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3 p/ZEB1 Axis.
      Title: CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3 p/ZEB1 Axis.
    8. ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions.
      Title: ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions.
    9. LINC01806 Promotes Breast Cancer Growth and Metastasis via Sponging miR-1286 to Disinhibit ZEB1 Expression.
      Title: LINC01806 Promotes Breast Cancer Growth and Metastasis via Sponging miR-1286 to Disinhibit ZEB1 Expression.
    10. GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via beta-catenin signaling in hepatocellular carcinoma.
      Title: GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via β-catenin signaling in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (590)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Corneal dystrophy, Fuchs endothelial, 6
    MedGen: C2750448 OMIM: 613270 GeneReviews: Not available
    		Compare labs
    Posterior polymorphous corneal dystrophy 3
    MedGen: C1836724 OMIM: 609141 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef upregulates the expression of transcription factor 8 in HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133261

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pattern specification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in semicircular canal morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger E-box-binding homeobox 1
    Names
    delta-crystallin enhancer binding factor 1
    negative regulator of IL2
    posterior polymorphous corneal dystrophy 3
    transcription factor 8 (represses interleukin 2 expression)
    zinc finger homeodomain enhancer-binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017048.2 RefSeqGene

      Range
      5801..216389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128128.3 → NP_001121600.1  zinc finger E-box-binding homeobox 1 isoform a

      See identical proteins and their annotated locations for NP_001121600.1

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      Consensus CDS
      CCDS44370.1
      UniProtKB/TrEMBL
      B2RBI8
      Related
      ENSP00000391612.2, ENST00000446923.7
      Conserved Domains (5) summary
      smart00389
      Location:577 → 613
      HOX; Homeodomain
      COG5271
      Location:1 → 181
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      sd00017
      Location:890 → 910
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224 → 246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:930 → 955
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001174093.2 → NP_001167564.1  zinc finger E-box-binding homeobox 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AI086650, AL831979, BC112392, BQ003893, BX111519, DC299346
      Consensus CDS
      CCDS53506.1
      UniProtKB/TrEMBL
      B2RBI8
      Related
      ENSP00000452787.1, ENST00000560721.6
      Conserved Domains (5) summary
      smart00389
      Location:573 → 609
      HOX; Homeodomain
      COG5048
      Location:909 → 962
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:886 → 906
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:926 → 951
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001174094.2 → NP_001167565.1  zinc finger E-box-binding homeobox 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AI086650, AK311116, AK311187, AK311557, AK314683, AL831979, BQ003893, BX111519, U12170
      UniProtKB/TrEMBL
      B2RBI8
      Conserved Domains (5) summary
      smart00389
      Location:576 → 612
      HOX; Homeodomain
      COG5271
      Location:1 → 180
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      sd00017
      Location:889 → 909
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:223 → 245
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:929 → 954
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001174095.2 → NP_001167566.1  zinc finger E-box-binding homeobox 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AI086650, AK300830, AK314683, AL831979, BQ003893, BX111519, DC299346, U12170
      Consensus CDS
      CCDS53507.1
      UniProtKB/TrEMBL
      B2RBI8
      Related
      ENSP00000444891.2, ENST00000542815.7
      Conserved Domains (5) summary
      smart00389
      Location:526 → 562
      HOX; Homeodomain
      COG5048
      Location:862 → 915
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:839 → 859
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:173 → 195
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:879 → 904
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001174096.2 → NP_001167567.1  zinc finger E-box-binding homeobox 1 isoform f

      See identical proteins and their annotated locations for NP_001167567.1

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      Consensus CDS
      CCDS53505.1
      UniProtKB/TrEMBL
      B2RBI8
      Related
      ENSP00000415961.2, ENST00000424869.6
      Conserved Domains (4) summary
      smart00389
      Location:594 → 630
      HOX; Homeodomain
      sd00017
      Location:907 → 927
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 263
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:947 → 972
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001323638.2 → NP_001310567.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL161935, AL355148, BX647794
      UniProtKB/TrEMBL
      B4DGU2
      Related
      ENST00000488625.6
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001323641.2 → NP_001310570.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AK294775, AL161935
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001323642.2 → NP_001310571.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001323643.2 → NP_001310572.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001323644.2 → NP_001310573.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    11. NM_001323645.2 → NP_001310574.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    12. NM_001323646.2 → NP_001310575.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AK311372, AL117340, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    13. NM_001323647.2 → NP_001310576.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    14. NM_001323648.2 → NP_001310577.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    15. NM_001323649.2 → NP_001310578.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    16. NM_001323650.2 → NP_001310579.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    17. NM_001323651.2 → NP_001310580.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AK307510, AL158080, AL161935
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    18. NM_001323652.2 → NP_001310581.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161935, AL355148, DB276952
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    19. NM_001323653.2 → NP_001310582.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161935, AL355148, AL831979
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    20. NM_001323654.2 → NP_001310583.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AK308822, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    21. NM_001323655.2 → NP_001310584.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL161935, AL355148, BX954549
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    22. NM_001323656.2 → NP_001310585.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    23. NM_001323657.2 → NP_001310586.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    24. NM_001323658.2 → NP_001310587.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL161935, AL355148, DC403144
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    25. NM_001323659.2 → NP_001310588.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    26. NM_001323660.2 → NP_001310589.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    27. NM_001323661.2 → NP_001310590.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AK309399, AL158080, AL161935, AL355148, DC375708
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    28. NM_001323662.2 → NP_001310591.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    29. NM_001323663.2 → NP_001310592.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    30. NM_001323664.2 → NP_001310593.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    31. NM_001323665.2 → NP_001310594.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    32. NM_001323666.2 → NP_001310595.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    33. NM_001323671.2 → NP_001310600.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    34. NM_001323672.2 → NP_001310601.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    35. NM_001323673.2 → NP_001310602.1  zinc finger E-box-binding homeobox 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B4DGU2
      Conserved Domains (4) summary
      smart00389
      Location:375 → 411
      HOX; Homeodomain
      sd00017
      Location:688 → 708
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:22 → 44
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    36. NM_001323674.2 → NP_001310603.1  zinc finger E-box-binding homeobox 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B2RBI8

    37. NM_001323675.2 → NP_001310604.1  zinc finger E-box-binding homeobox 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B2RBI8

    38. NM_001323676.2 → NP_001310605.1  zinc finger E-box-binding homeobox 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B2RBI8

    39. NM_001323677.2 → NP_001310606.1  zinc finger E-box-binding homeobox 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B2RBI8

    40. NM_001323678.2 → NP_001310607.1  zinc finger E-box-binding homeobox 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL117340, AL158080, AL161935, AL355148
      UniProtKB/TrEMBL
      B2RBI8

    41. NM_030751.6 → NP_110378.3  zinc finger E-box-binding homeobox 1 isoform b

      See identical proteins and their annotated locations for NP_110378.3

      Status: REVIEWED

      Source sequence(s)
      AI086650, AK314683, AL831979, BQ003893, BX111519, U12170
      Consensus CDS
      CCDS7169.1
      UniProtKB/Swiss-Prot
      B4DJV0, B4DUW9, E9PCM7, F5H4I8, P37275, Q12924, Q13800, Q2KJ05, Q5T968, Q5VZ84, Q8NB68
      UniProtKB/TrEMBL
      B2RBI8
      Related
      ENSP00000319248.9, ENST00000320985.14
      Conserved Domains (5) summary
      smart00389
      Location:593 → 629
      HOX; Homeodomain
      COG5271
      Location:27 → 197
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      sd00017
      Location:906 → 926
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 262
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:946 → 971
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      31318417..31529804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425691.1 → XP_047281647.1  zinc finger E-box-binding homeobox 1 isoform X1

    2. XM_047425695.1 → XP_047281651.1  zinc finger E-box-binding homeobox 1 isoform X1

    3. XM_047425684.1 → XP_047281640.1  zinc finger E-box-binding homeobox 1 isoform X1

    4. XM_047425689.1 → XP_047281645.1  zinc finger E-box-binding homeobox 1 isoform X1

    5. XM_047425685.1 → XP_047281641.1  zinc finger E-box-binding homeobox 1 isoform X1

    6. XM_047425688.1 → XP_047281644.1  zinc finger E-box-binding homeobox 1 isoform X1

    7. XM_047425696.1 → XP_047281652.1  zinc finger E-box-binding homeobox 1 isoform X1

    8. XM_047425687.1 → XP_047281643.1  zinc finger E-box-binding homeobox 1 isoform X1

    9. XM_047425694.1 → XP_047281650.1  zinc finger E-box-binding homeobox 1 isoform X1

    10. XM_047425686.1 → XP_047281642.1  zinc finger E-box-binding homeobox 1 isoform X1

    11. XM_047425690.1 → XP_047281646.1  zinc finger E-box-binding homeobox 1 isoform X1

    12. XM_047425692.1 → XP_047281648.1  zinc finger E-box-binding homeobox 1 isoform X1

    13. XM_047425683.1 → XP_047281639.1  zinc finger E-box-binding homeobox 1 isoform X1

    14. XM_047425682.1 → XP_047281638.1  zinc finger E-box-binding homeobox 1 isoform X1

    15. XM_047425693.1 → XP_047281649.1  zinc finger E-box-binding homeobox 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      31348155..31559554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366657.1 → XP_054222632.1  zinc finger E-box-binding homeobox 1 isoform X1

    2. XM_054366661.1 → XP_054222636.1  zinc finger E-box-binding homeobox 1 isoform X1

    3. XM_054366650.1 → XP_054222625.1  zinc finger E-box-binding homeobox 1 isoform X1

    4. XM_054366655.1 → XP_054222630.1  zinc finger E-box-binding homeobox 1 isoform X1

    5. XM_054366651.1 → XP_054222626.1  zinc finger E-box-binding homeobox 1 isoform X1

    6. XM_054366654.1 → XP_054222629.1  zinc finger E-box-binding homeobox 1 isoform X1

    7. XM_054366662.1 → XP_054222637.1  zinc finger E-box-binding homeobox 1 isoform X1

    8. XM_054366653.1 → XP_054222628.1  zinc finger E-box-binding homeobox 1 isoform X1

    9. XM_054366660.1 → XP_054222635.1  zinc finger E-box-binding homeobox 1 isoform X1

    10. XM_054366652.1 → XP_054222627.1  zinc finger E-box-binding homeobox 1 isoform X1

    11. XM_054366656.1 → XP_054222631.1  zinc finger E-box-binding homeobox 1 isoform X1

    12. XM_054366658.1 → XP_054222633.1  zinc finger E-box-binding homeobox 1 isoform X1

    13. XM_054366649.1 → XP_054222624.1  zinc finger E-box-binding homeobox 1 isoform X1

    14. XM_054366648.1 → XP_054222623.1  zinc finger E-box-binding homeobox 1 isoform X1

    15. XM_054366659.1 → XP_054222634.1  zinc finger E-box-binding homeobox 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37275.2 GenPept UniProtKB/Swiss-Prot:P37275

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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