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    ZNF37A zinc finger protein 37A [ Homo sapiens (human) ]

    Gene ID: 7587, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZNF37Aprovided by HGNC
    Official Full Name
    zinc finger protein 37Aprovided by HGNC
    Primary source
    HGNC:HGNC:13102
    See related
    Ensembl:ENSG00000075407 MIM:616085; AllianceGenome:HGNC:13102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX21; ZNF37
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.1), endometrium (RPKM 2.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF37A in Genome Data Viewer
    Location:
    10p11.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (38094337..38150293)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (38138318..38194251)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38383265..38439221)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3274 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2 Neighboring gene uncharacterized LOC105376500 Neighboring gene cyclin Y like 4 (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ3472

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 37A
    Names
    zinc finger protein 37a (KOX 21)
    zinc finger protein KOX21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007094.4NP_001007095.1  zinc finger protein 37A isoform a

      See identical proteins and their annotated locations for NP_001007095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Related
      ENSP00000329141.3, ENST00000351773.7
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001178101.3NP_001171572.1  zinc finger protein 37A isoform a

      See identical proteins and their annotated locations for NP_001171572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment and uses a different splice site in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same protein.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001324245.3NP_001311174.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1-3 and 5-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001324246.3NP_001311175.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1-4 and 6-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001324247.3NP_001311176.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1-5 and 7-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    6. NM_001324248.3NP_001311177.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1-6 and 8-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001324249.3NP_001311178.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1-7 and 9-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    8. NM_001324250.3NP_001311179.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Related
      ENSP00000508865.1, ENST00000685332.1
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    9. NM_001324251.3NP_001311180.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1-9, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    10. NM_001324252.2NP_001311181.1  zinc finger protein 37A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform b.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    11. NM_001324253.2NP_001311182.1  zinc finger protein 37A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform b.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    12. NM_001324254.2NP_001311183.1  zinc finger protein 37A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform b.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    13. NM_001324256.2NP_001311185.1  zinc finger protein 37A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 15-16, encodes isoform c.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS81451.1
      UniProtKB/TrEMBL
      A0A1B0GVV4
      Related
      ENSP00000490669.1, ENST00000638053.1
    14. NM_001324257.2NP_001311186.1  zinc finger protein 37A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform c.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS81451.1
      UniProtKB/TrEMBL
      A0A1B0GVV4
    15. NM_001324258.2NP_001311187.1  zinc finger protein 37A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 14-15, encodes isoform c.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS81451.1
      UniProtKB/TrEMBL
      A0A1B0GVV4
    16. NM_001324259.3NP_001311188.1  zinc finger protein 37A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) and variant 18 both encode isoform d.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    17. NM_001324260.3NP_001311189.1  zinc finger protein 37A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) and variant 17 both encode isoform d.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    18. NM_001324261.2NP_001311190.1  zinc finger protein 37A isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) and variant 20 both encode isoform e.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    19. NM_001324262.2NP_001311191.1  zinc finger protein 37A isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) and variant 19 both encode isoform e.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    20. NM_003421.4NP_003412.1  zinc finger protein 37A isoform a

      See identical proteins and their annotated locations for NP_003412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Related
      ENSP00000354377.4, ENST00000361085.9
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      38094337..38150293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425722.1XP_047281678.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
    2. XM_011519656.3XP_011517958.1  zinc finger protein 37A isoform X1

      See identical proteins and their annotated locations for XP_011517958.1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011519657.3XP_011517959.1  zinc finger protein 37A isoform X1

      See identical proteins and their annotated locations for XP_011517959.1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011519658.4XP_011517960.1  zinc finger protein 37A isoform X1

      See identical proteins and their annotated locations for XP_011517960.1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426448
      zf-H2C2_2; Zinc-finger double domain
    5. XM_017016624.1XP_016872113.1  zinc finger protein 37A isoform X5

      Related
      ENST00000479469.5
      Conserved Domains (1) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
    6. XM_047425724.1XP_047281680.1  zinc finger protein 37A isoform X4

    7. XM_047425723.1XP_047281679.1  zinc finger protein 37A isoform X3

    8. XM_005252586.5XP_005252643.1  zinc finger protein 37A isoform X2

      See identical proteins and their annotated locations for XP_005252643.1

      Conserved Domains (3) summary
      COG5048
      Location:55471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:211231
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:307331
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      38138318..38194251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366696.1XP_054222671.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
    2. XM_054366695.1XP_054222670.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
    3. XM_054366698.1XP_054222673.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
    4. XM_054366697.1XP_054222672.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
    5. XM_054366702.1XP_054222677.1  zinc finger protein 37A isoform X5

    6. XM_054366701.1XP_054222676.1  zinc finger protein 37A isoform X4

    7. XM_054366700.1XP_054222675.1  zinc finger protein 37A isoform X3

    8. XM_054366699.1XP_054222674.1  zinc finger protein 37A isoform X2