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    ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 455326, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ROCK1provided by VGNC
    Official Full Name
    Rho associated coiled-coil containing protein kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:7330
    Locus tag
    CK820_G0018554
    See related
    Ensembl:ENSPTRG00000009904
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    ROCK-I; p160ROCK
    Orthologs
    human mouse all
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    Genomic context

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    See ROCK1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 17 NC_072415.2 (30793377..30953110, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 18 NC_072416.1 (29718621..29878345, complement)

    Chromosome 17 - NC_072415.2Genomic Context describing neighboring genes Neighboring gene THO complex subunit 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene U6 spliceosomal RNA Neighboring gene nuclease EXOG, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution. Dennehey BK, et al. Genomics, 2004 Mar. PMID 14962675
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho-associated protein kinase 1
    Names
    Rho-associated protein kinase 1
    p160 ROCK-1
    rho-associated, coiled-coil-containing protein kinase 1
    rho-associated, coiled-coil-containing protein kinase I
    XP_001151982.1
    XP_016788908.1
    XP_016788909.1
    XP_054527969.1
    XP_063652090.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      30793377..30953110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063796020.1 → XP_063652090.1  rho-associated protein kinase 1 isoform X4

      UniProtKB/Swiss-Prot
      P61584

    2. XM_016933419.4 → XP_016788908.1  rho-associated protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3T6I0

    3. XM_001151982.5 → XP_001151982.1  rho-associated protein kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_001151982.1

      UniProtKB/TrEMBL
      A0A2I3T6I0, A0A2J8MPD5, A0A6D2WAN4, H2QEB3
      Related
      ENSPTRP00000016847.4
      Conserved Domains (5) summary
      cd11639
      Location:489 → 554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      COG0419
      Location:422 → 1027
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1229 → 1275
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1119 → 1225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

    4. XM_016933420.3 → XP_016788909.1  rho-associated protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3T6I0

    5. XM_054671994.2 → XP_054527969.1  rho-associated protein kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A2J8MPE0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61584.1 GenPept UniProtKB/Swiss-Prot:P61584

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