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    SPRR2G small proline rich protein 2G [ Homo sapiens (human) ]

    Gene ID: 6706, updated on 27-Nov-2024

    Summary

    Official Symbol
    SPRR2Gprovided by HGNC
    Official Full Name
    small proline rich protein 2Gprovided by HGNC
    Primary source
    HGNC:HGNC:11267
    See related
    Ensembl:ENSG00000159516 MIM:617590; AllianceGenome:HGNC:11267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in keratinization. Predicted to act upstream of or within response to estradiol. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in esophagus (RPKM 33.8) and skin (RPKM 27.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPRR2G in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153149582..153203278, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152286400..152339804, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153122058..153123366, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 2F Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:153095261-153096004 Neighboring gene NANOG hESC enhancer GRCh37_chr1:153107702-153108203 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153112641-153113840 Neighboring gene small proline rich protein 2C (pseudogene) Neighboring gene uncharacterized LOC101928009 Neighboring gene late cornified envelope like proline rich 1 Neighboring gene proline rich 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in epidermis development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cornified envelope NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cornified envelope TAS
    Traceable Author Statement
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    small proline-rich protein 2G
    Names
    SPR-2G

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014291.4NP_001014313.1  small proline-rich protein 2G

      See identical proteins and their annotated locations for NP_001014313.1

      Status: VALIDATED

      Source sequence(s)
      AL157405, BC133041
      Consensus CDS
      CCDS30868.1
      UniProtKB/Swiss-Prot
      Q9BYE4
      Related
      ENSP00000357737.4, ENST00000368748.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153149582..153203278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002177.2XP_016857666.1  small proline-rich protein 2G isoform X1

      UniProtKB/Swiss-Prot
      Q9BYE4
    2. XM_017002178.2XP_016857667.1  small proline-rich protein 2G isoform X1

      UniProtKB/Swiss-Prot
      Q9BYE4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152286400..152339804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338463.1XP_054194438.1  small proline-rich protein 2G isoform X1

      UniProtKB/Swiss-Prot
      Q9BYE4