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    Zswim8 zinc finger SWIM-type containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 268721, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zswim8provided by MGI
    Official Full Name
    zinc finger SWIM-type containing 8provided by MGI
    Primary source
    MGI:MGI:1919156
    See related
    Ensembl:ENSMUSG00000021819 AllianceGenome:MGI:1919156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0913; mKIAA0913; 2310021P13Rik; 4832404P21Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 52.4), adrenal adult (RPKM 48.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zswim8 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20756346..20773687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20706277..20723619)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6230400D17 gene Neighboring gene predicted gene, 25328 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Shi CY, et al. Genome Res, 2023 Sep. PMID 37532519, Free PMC Article
    2. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. Okumura F, et al. Sci Rep, 2021 Oct 22. PMID 34686700, Free PMC Article
    3. Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals. Jones BT, et al. Genes Dev, 2023 Jul 1. PMID 37553261, Free PMC Article
    4. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Wang Z, et al. Neuron, 2013 Sep 4. PMID 24012004, Free PMC Article
    5. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi CY, et al. Science, 2020 Dec 18. PMID 33184237, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development.
      Title: ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in target-directed miRNA degradation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252081.2 → NP_001239010.1  zinc finger SWIM domain-containing protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS88588.1
      UniProtKB/TrEMBL
      B7ZWK9
      Related
      ENSMUSP00000153285.2, ENSMUST00000224751.2
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    2. NM_001252082.2 → NP_001239011.1  zinc finger SWIM domain-containing protein 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS88587.1
      UniProtKB/TrEMBL
      B7ZWK9
      Related
      ENSMUSP00000153027.2, ENSMUST00000223840.2
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    3. NM_001408318.1 → NP_001395247.1  zinc finger SWIM domain-containing protein 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121599

    4. NM_027996.4 → NP_082272.1  zinc finger SWIM domain-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_082272.1

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS36820.1
      UniProtKB/Swiss-Prot
      B2RX90, Q3UHH1, Q5U4B9, Q6PCY6, Q80Y41, Q8CE12, Q8CHC3, Q9D789
      UniProtKB/TrEMBL
      B7ZWK9
      Related
      ENSMUSP00000022358.8, ENSMUST00000022358.9
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20756346..20773687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519034.5 → XP_006519097.1  zinc finger SWIM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      B7ZWK9
      Conserved Domains (2) summary
      pfam03154
      Location:1491 → 1661
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:1016 → 1158
      Treacle; Treacher Collins syndrome protein Treacle

    2. XM_006519035.5 → XP_006519098.1  zinc finger SWIM domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      B7ZWK9
      Conserved Domains (2) summary
      pfam03154
      Location:1484 → 1654
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:1009 → 1151
      Treacle; Treacher Collins syndrome protein Treacle

    3. XM_006519037.5 → XP_006519100.1  zinc finger SWIM domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      B7ZWK9
      Conserved Domains (2) summary
      pfam03154
      Location:1457 → 1627
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:982 → 1124
      Treacle; Treacher Collins syndrome protein Treacle

    4. XM_006519039.2 → XP_006519102.1  zinc finger SWIM domain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      B7ZWK9
      Conserved Domains (2) summary
      pfam03154
      Location:1286 → 1456
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:811 → 953
      Treacle; Treacher Collins syndrome protein Treacle

    5. XM_006519036.5 → XP_006519099.1  zinc finger SWIM domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      B7ZWK9
      Conserved Domains (3) summary
      PHA03247
      Location:1529 → 1844
      PHA03247; large tegument protein UL36; Provisional
      pfam03154
      Location:1491 → 1653
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:1016 → 1158
      Treacle; Treacher Collins syndrome protein Treacle

    6. XM_017316025.1 → XP_017171514.1  zinc finger SWIM domain-containing protein 8 isoform X7

      Conserved Domains (2) summary
      pfam03154
      Location:500 → 670
      Atrophin-1; Atrophin-1 family
      pfam03546
      Location:25 → 167
      Treacle; Treacher Collins syndrome protein Treacle

    RNA

    1. XR_003950855.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHH1.1 GenPept UniProtKB/Swiss-Prot:Q3UHH1

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