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    Mei1 meiotic double-stranded break formation protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 74369, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mei1provided by MGI
    Official Full Name
    meiotic double-stranded break formation protein 1provided by MGI
    Primary source
    MGI:MGI:3028590
    See related
    Ensembl:ENSMUSG00000068117 AllianceGenome:MGI:3028590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mei1; 4932408F18Rik
    Summary
    Acts upstream of or within germ cell development; meiotic nuclear division; and meiotic spindle organization. Is expressed in brain; ovary; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human MEI1 (meiotic double-stranded break formation protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 3.0), cortex adult (RPKM 1.4) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mei1 in Genome Data Viewer
    Location:
    15 E1; 15 38.41 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81954275..82011018)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82070074..82126817)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene RIKEN cDNA 4930407I10 gene Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene STARR-seq mESC enhancer starr_39280 Neighboring gene STARR-seq mESC enhancer starr_39281 Neighboring gene STARR-positive B cell enhancer ABC_E8600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:81965919-81966120 Neighboring gene coiled-coil domain containing 134 Neighboring gene STARR-seq mESC enhancer starr_39283 Neighboring gene sterol regulatory element binding factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E5500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:81996613-81996854 Neighboring gene STARR-seq mESC enhancer starr_39286 Neighboring gene microRNA 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A dominant, recombination-defective allele of Dmc1 causing male-specific sterility. Bannister LA, et al. PLoS Biol, 2007 May. PMID 17425408, Free PMC Article
    2. Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles. Nguyen NMP, et al. Am J Hum Genet, 2018 Nov 1. PMID 30388401, Free PMC Article
    3. The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression. Libby BJ, et al. Dev Biol, 2002 Feb 15. PMID 11820814
    4. Mei1 is epistatic to Dmc1 during mouse meiosis. Reinholdt LG, et al. Chromosoma, 2005 Jul. PMID 15928951
    5. Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Boateng KA, et al. Dev Cell, 2013 Jan 28. PMID 23318132, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mei1 is required for vertebrate meiosis.
      Title: Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.
    2. Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis.
      Title: Mei1 is epistatic to Dmc1 during mouse meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (other) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leptotene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiosis inhibitor protein 1
    Names
    meiosis defective protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310435.1 → NP_001297364.1  meiosis inhibitor protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001297364.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC102176, AK016514
      Consensus CDS
      CCDS79396.1
      UniProtKB/Swiss-Prot
      Q9D4I2
      Related
      ENSMUSP00000139689.2, ENSMUST00000188048.7

    2. NM_028897.3 → NP_083173.2  meiosis inhibitor protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102176, AK016514, BY641487
      Consensus CDS
      CCDS88810.1
      UniProtKB/Swiss-Prot
      B2RQ44, F8WHB9, Q9D4I2
      UniProtKB/TrEMBL
      A0A2R8VHD2
      Related
      ENSMUSP00000086582.6, ENSMUST00000089178.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81954275..82011018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521494.4 → XP_006521557.1  meiosis inhibitor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8VHD2

    2. XM_006521495.4 → XP_006521558.1  meiosis inhibitor protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A2R8VHD2

    3. XM_017316770.2 → XP_017172259.1  meiosis inhibitor protein 1 isoform X4

    4. XM_006521496.5 → XP_006521559.1  meiosis inhibitor protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006521559.1

      UniProtKB/TrEMBL
      A0A2R8VHD2

    5. XM_030248803.2 → XP_030104663.1  meiosis inhibitor protein 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4I2.4 GenPept UniProtKB/Swiss-Prot:Q9D4I2

    Gene LinkOut

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