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    Kalrn kalirin, RhoGEF kinase [ Mus musculus (house mouse) ]

    Gene ID: 545156, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kalrnprovided by MGI
    Official Full Name
    kalirin, RhoGEF kinaseprovided by MGI
    Primary source
    MGI:MGI:2685385
    See related
    Ensembl:ENSMUSG00000061751 AllianceGenome:MGI:2685385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DUET; TRAD; Gm539; Hapip; 2210407G14Rik; E530005C20Rik
    Summary
    Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including learning or memory; maternal behavior; and maternal process involved in parturition. Predicted to be located in several cellular components, including neuronal cell body; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density; and presynapse. Predicted to be extrinsic component of membrane. Is expressed in cerebral cortex ventricular layer; cortical plate; dorsal root ganglion; and spinal cord. Human ortholog(s) of this gene implicated in cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 11.3), frontal lobe adult (RPKM 7.9) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kalrn in Genome Data Viewer
    Location:
    16 B3; 16 24.27 cM
    Exon count:
    69
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33789443..34393647, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33969073..34573277, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40715 Neighboring gene STARR-seq mESC enhancer starr_40716 Neighboring gene STARR-seq mESC enhancer starr_40719 Neighboring gene integrin beta 5 Neighboring gene STARR-positive B cell enhancer ABC_E8630 Neighboring gene STARR-seq mESC enhancer starr_40721 Neighboring gene VISTA enhancer mm268 Neighboring gene uridine monophosphate synthetase Neighboring gene STARR-seq mESC enhancer starr_40723 Neighboring gene STARR-seq mESC enhancer starr_40724 Neighboring gene predicted gene, 41448 Neighboring gene STARR-seq mESC enhancer starr_40725 Neighboring gene STARR-positive B cell enhancer ABC_E5539 Neighboring gene ropporin, rhophilin associated protein 1 Neighboring gene predicted gene, 35150 Neighboring gene coiled-coil domain containing 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. Lemtiri-Chlieh F, et al. BMC Neurosci, 2011 Dec 19. PMID 22182308, Free PMC Article
    2. Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice. Moyer CE, et al. Cereb Cortex, 2016 May. PMID 25759333, Free PMC Article
    3. Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl. Ma XM, et al. Mol Biol Cell, 2014 May. PMID 24600045, Free PMC Article
    4. Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7. Miller MB, et al. J Neurochem, 2017 Mar. PMID 27465683, Free PMC Article
    5. Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration. Kiraly DD, et al. Mol Pharmacol, 2013 Oct. PMID 23894151, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
      Title: Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
    2. KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
      Title: KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
    3. Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
      Title: Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
    4. Kalirin reduction in APPswe/PSEN1dE9 mice significantly attenuated psychosis-associated behavior at 12 months of age without changing spatial memory performance.
      Title: Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
    5. Kalirin-7 plays a prominent role in nociceptive sensitization via activity-dependent modulation of spinal synapses.
      Title: A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
    6. lack of Kalrn expression in POMC cells closely mimicked the effects of global Kalrn knockout on anxiety-like behavior and passive avoidance conditioning
      Title: Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.
    7. Kal7 may allow coordination of the many signaling pathways contributing to dendritic spine morphogenesis.
      Title: Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.
    8. Kalirin may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass.
      Title: The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
    9. Kalerin-7 knock-out mice exhibit increased self-administration of cocaine compared to wild-type mice.
      Title: Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.
    10. Many of the widespread and diverse deficits observed both within and outside of the nervous system when expression of Kalrn is eliminated may reflect its role in secretory granule function and its expression outside of the nervous system.
      Title: Kalrn plays key roles within and outside of the nervous system.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NMDA selective glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal process involved in parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kalirin
    Names
    huntingtin-associated protein interacting protein (duo)
    protein Duo
    serine/threonine kinase with Dbl- and pleckstrin homology domain
    serine/threonine kinase with Dbl- and pleckstrin homology domains
    serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
    NP_001157740.1
    NP_796331.2
    XP_006522426.1
    XP_006522427.1
    XP_006522433.1
    XP_006522443.1
    XP_006522444.1
    XP_006522445.1
    XP_006522446.1
    XP_006522448.1
    XP_006522449.1
    XP_011244253.1
    XP_011244254.1
    XP_011244255.1
    XP_011244256.1
    XP_011244257.1
    XP_011244258.1
    XP_011244259.1
    XP_011244260.1
    XP_011244261.1
    XP_011244262.1
    XP_011244263.1
    XP_011244265.1
    XP_011244267.1
    XP_011244268.1
    XP_011244269.1
    XP_011244270.1
    XP_017172560.1
    XP_017172561.1
    XP_017172562.1
    XP_017172563.1
    XP_017172564.1
    XP_017172565.1
    XP_017172566.1
    XP_017172568.1
    XP_017172569.1
    XP_017172570.1
    XP_017172571.1
    XP_030105050.1
    XP_030105051.1
    XP_030105052.1
    XP_036015907.1
    XP_036015909.1
    XP_036015910.1
    XP_036015912.1
    XP_036015913.1
    XP_036015914.1
    XP_036015916.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164268.1 → NP_001157740.1  kalirin isoform 2

      See identical proteins and their annotated locations for NP_001157740.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK147518, BC157950
      Consensus CDS
      CCDS49836.1
      UniProtKB/TrEMBL
      B1B1A7
      Related
      ENSMUSP00000110611.3, ENSMUST00000114960.9
      Conserved Domains (5) summary
      smart00150
      Location:1126 → 1226
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    2. NM_177357.3 → NP_796331.2  kalirin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AC154524, AC154588, AC165079, CT010573
      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Related
      ENSMUSP00000076088.6, ENSMUST00000076810.12
      Conserved Domains (17) summary
      cd00096
      Location:2478 → 2552
      Ig; Immunoglobulin domain
      smart00150
      Location:1126 → 1226
      SPEC; Spectrin repeats
      cd11852
      Location:1640 → 1699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2314 → 2370
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2674 → 2928
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2559 → 2650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2242 → 2294
      Extensin_2; Extensin-like region
      pfam07679
      Location:2461 → 2555
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2096 → 2230
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2680 → 2927
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1485 → 1570
      PH; PH domain
      pfam00621
      Location:1922 → 2092
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1697 → 1921
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33789443..34393647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245955.2 → XP_011244257.1  kalirin isoform X6

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1137 → 1237
      SPEC; Spectrin repeats
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2325 → 2381
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2570 → 2661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:893 → 1131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2253 → 2305
      Extensin_2; Extensin-like region
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2691 → 2938
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1933 → 2102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2472 → 2566
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1708 → 1923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    2. XM_006522386.4 → XP_006522449.1  kalirin isoform X45

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1121 → 1221
      SPEC; Spectrin repeats
      cd11852
      Location:1635 → 1694
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2309 → 2365
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2534 → 2625
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1270 → 1440
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:886 → 1115
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2237 → 2289
      Extensin_2; Extensin-like region
      cd13240
      Location:1447 → 1569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2091 → 2225
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2655 → 2902
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1917 → 2086
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2436 → 2530
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1692 → 1907
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    3. XM_006522370.4 → XP_006522433.1  kalirin isoform X11

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1121 → 1221
      SPEC; Spectrin repeats
      cd11852
      Location:1635 → 1694
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2309 → 2365
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2554 → 2645
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1270 → 1440
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:886 → 1115
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2237 → 2289
      Extensin_2; Extensin-like region
      cd13240
      Location:1447 → 1569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2091 → 2225
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2675 → 2922
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1917 → 2086
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2456 → 2550
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1692 → 1907
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    4. XM_036160016.1 → XP_036015909.1  kalirin isoform X16

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1130 → 1230
      SPEC; Spectrin repeats
      cd11852
      Location:1644 → 1703
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2286 → 2342
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2531 → 2622
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1279 → 1449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:545 → 761
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1456 → 1578
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2069 → 2203
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2652 → 2899
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1895 → 2064
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2433 → 2527
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1701 → 1892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2425 → 2428
      Ig; Ig strand A [structural motif]

    5. XM_011245956.3 → XP_011244258.1  kalirin isoform X9

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1130 → 1230
      SPEC; Spectrin repeats
      cd11852
      Location:1644 → 1703
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2318 → 2374
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2563 → 2654
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1279 → 1449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:545 → 761
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2246 → 2298
      Extensin_2; Extensin-like region
      cd13240
      Location:1456 → 1578
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2100 → 2234
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2684 → 2931
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1926 → 2095
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2465 → 2559
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1701 → 1916
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    6. XM_006522364.4 → XP_006522427.1  kalirin isoform X8

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1134 → 1234
      SPEC; Spectrin repeats
      cd11852
      Location:1648 → 1707
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2322 → 2378
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2567 → 2658
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1283 → 1453
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1128
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2250 → 2302
      Extensin_2; Extensin-like region
      cd13240
      Location:1460 → 1582
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2104 → 2238
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2688 → 2935
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1930 → 2099
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2469 → 2563
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1705 → 1920
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    7. XM_011245961.3 → XP_011244263.1  kalirin isoform X14

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2299 → 2355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2544 → 2635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2227 → 2279
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2081 → 2215
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2665 → 2912
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1907 → 2076
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2446 → 2540
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    8. XM_036160014.1 → XP_036015907.1  kalirin isoform X4

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2329 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2574 → 2665
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2112 → 2246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2695 → 2942
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1938 → 2107
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2476 → 2570
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1895
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2468 → 2471
      Ig; Ig strand A [structural motif]

    9. XM_011245952.3 → XP_011244254.1  kalirin isoform X2

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2330 → 2386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2575 → 2666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2258 → 2310
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2112 → 2246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2696 → 2943
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1938 → 2107
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2477 → 2571
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1928
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    10. XM_017317071.2 → XP_017172560.1  kalirin isoform X15

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2299 → 2355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2544 → 2635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2228 → 2280
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2082 → 2216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2665 → 2912
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1908 → 2077
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2446 → 2540
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1863
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    11. XM_011245960.3 → XP_011244262.1  kalirin isoform X13

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2300 → 2356
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2545 → 2636
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2228 → 2280
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2082 → 2216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2666 → 2913
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1908 → 2077
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2447 → 2541
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1863
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    12. XM_011245953.3 → XP_011244255.1  kalirin isoform X3

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2330 → 2386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2575 → 2666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2696 → 2943
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2477 → 2571
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    13. XM_011245957.3 → XP_011244259.1  kalirin isoform X10

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2331 → 2387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2556 → 2647
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2677 → 2924
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2458 → 2552
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    14. XM_011245951.3 → XP_011244253.1  kalirin isoform X1

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2331 → 2387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2576 → 2667
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2697 → 2944
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2478 → 2572
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    15. XM_006522363.5 → XP_006522426.1  kalirin isoform X7

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2323 → 2379
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2568 → 2659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2251 → 2303
      Extensin_2; Extensin-like region
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2105 → 2239
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2689 → 2936
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1931 → 2100
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2470 → 2564
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1921
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    16. XM_011245954.4 → XP_011244256.1  kalirin isoform X5

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1138 → 1238
      SPEC; Spectrin repeats
      cd11852
      Location:1652 → 1711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2326 → 2382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42 → 180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2571 → 2662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1287 → 1457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:894 → 1132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2254 → 2306
      Extensin_2; Extensin-like region
      cd13240
      Location:1464 → 1586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2108 → 2242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2692 → 2939
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1934 → 2103
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2473 → 2567
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1709 → 1924
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    17. XM_011245959.3 → XP_011244261.1  kalirin isoform X12

      See identical proteins and their annotated locations for XP_011244261.1

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1117 → 1217
      SPEC; Spectrin repeats
      cd11852
      Location:1631 → 1690
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2305 → 2361
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:21 → 159
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2550 → 2641
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1266 → 1436
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:873 → 1111
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2233 → 2285
      Extensin_2; Extensin-like region
      cd13240
      Location:1443 → 1565
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2087 → 2221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2671 → 2918
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1913 → 2082
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2452 → 2546
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1688 → 1903
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    18. XM_011245958.3 → XP_011244260.1  kalirin isoform X12

      See identical proteins and their annotated locations for XP_011244260.1

      UniProtKB/Swiss-Prot
      A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
      Conserved Domains (14) summary
      smart00150
      Location:1117 → 1217
      SPEC; Spectrin repeats
      cd11852
      Location:1631 → 1690
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2305 → 2361
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:21 → 159
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2550 → 2641
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1266 → 1436
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:873 → 1111
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2233 → 2285
      Extensin_2; Extensin-like region
      cd13240
      Location:1443 → 1565
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2087 → 2221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2671 → 2918
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1913 → 2082
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2452 → 2546
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1688 → 1903
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    19. XM_006522381.1 → XP_006522444.1  kalirin isoform X33

      Conserved Domains (13) summary
      smart00150
      Location:481 → 581
      SPEC; Spectrin repeats
      cd11852
      Location:995 → 1054
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:1669 → 1725
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:1914 → 2005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:630 → 800
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:237 → 475
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:1597 → 1649
      Extensin_2; Extensin-like region
      cd13240
      Location:807 → 929
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:1451 → 1585
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2035 → 2282
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1277 → 1446
      RhoGEF; RhoGEF domain
      pfam07679
      Location:1816 → 1910
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1052 → 1267
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    20. XM_036160023.1 → XP_036015916.1  kalirin isoform X32

      Conserved Domains (13) summary
      smart00150
      Location:485 → 585
      SPEC; Spectrin repeats
      cd11852
      Location:999 → 1058
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:1673 → 1729
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:1918 → 2009
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:634 → 804
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:250 → 479
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:811 → 933
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:1455 → 1589
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2039 → 2286
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1281 → 1450
      RhoGEF; RhoGEF domain
      pfam07679
      Location:1820 → 1914
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1056 → 1238
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:1812 → 1815
      Ig; Ig strand A [structural motif]

    21. XM_006522380.1 → XP_006522443.1  kalirin isoform X31

      Conserved Domains (14) summary
      smart00150
      Location:494 → 594
      SPEC; Spectrin repeats
      cd11852
      Location:1008 → 1067
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:1682 → 1738
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:1927 → 2018
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:643 → 813
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:250 → 488
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:1610 → 1662
      Extensin_2; Extensin-like region
      cd13240
      Location:820 → 942
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:1464 → 1598
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2048 → 2295
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      cl02488
      Location:5 → 249
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00621
      Location:1290 → 1459
      RhoGEF; RhoGEF domain
      pfam07679
      Location:1829 → 1923
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1065 → 1280
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    22. XM_006522385.5 → XP_006522448.1  kalirin isoform X39

      UniProtKB/TrEMBL
      D3Z4R2
      Related
      ENSMUSP00000110624.2, ENSMUST00000114973.9
      Conserved Domains (7) summary
      cd11853
      Location:627 → 683
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:872 → 963
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:409 → 543
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:993 → 1240
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:235 → 404
      RhoGEF; RhoGEF domain
      pfam07679
      Location:774 → 868
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:23 → 225
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    23. XM_017317077.3 → XP_017172566.1  kalirin isoform X40

      Conserved Domains (7) summary
      cd11853
      Location:626 → 682
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:871 → 962
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:409 → 543
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:992 → 1239
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:235 → 404
      RhoGEF; RhoGEF domain
      pfam07679
      Location:773 → 867
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:23 → 225
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    24. XM_036160017.1 → XP_036015910.1  kalirin isoform X18

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2331 → 2387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1896
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    25. XM_036160019.1 → XP_036015912.1  kalirin isoform X19

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2330 → 2386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1896
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    26. XM_011245963.3 → XP_011244265.1  kalirin isoform X17

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2331 → 2387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    27. XM_030249191.1 → XP_030105051.1  kalirin isoform X28

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (12) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2299 → 2355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2227 → 2279
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2081 → 2215
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1907 → 2076
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    28. XM_036160020.1 → XP_036015913.1  kalirin isoform X23

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (10) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2330 → 2386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2112 → 2246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1938 → 2107
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1895
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    29. XM_036160021.1 → XP_036015914.1  kalirin isoform X27

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2300 → 2356
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2082 → 2216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1908 → 2077
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1905
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    30. XM_011245965.3 → XP_011244267.1  kalirin isoform X20

      UniProtKB/TrEMBL
      F6QYT9
      Related
      ENSMUSP00000116188.2, ENSMUST00000142817.8
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2331 → 2387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    31. XM_011245966.3 → XP_011244268.1  kalirin isoform X21

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2331 → 2387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    32. XM_017317074.2 → XP_017172563.1  kalirin isoform X30

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (12) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2298 → 2354
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2227 → 2279
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2081 → 2215
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1907 → 2076
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    33. XM_030249190.1 → XP_030105050.1  kalirin isoform X25

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2329 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2258 → 2310
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2112 → 2246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1938 → 2107
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1928
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    34. XM_030249192.1 → XP_030105052.1  kalirin isoform X29

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (12) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2299 → 2355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2228 → 2280
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2082 → 2216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1908 → 2077
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1863
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    35. XM_017317072.3 → XP_017172561.1  kalirin isoform X22

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2330 → 2386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    36. XM_011245967.3 → XP_011244269.1  kalirin isoform X24

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (11) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2330 → 2386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2259 → 2311
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2113 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1939 → 2108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    37. XM_017317073.2 → XP_017172562.1  kalirin isoform X26

      UniProtKB/TrEMBL
      F6QYT9
      Conserved Domains (12) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1657 → 1716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2329 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:2258 → 2310
      Extensin_2; Extensin-like region
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2112 → 2246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:1938 → 2107
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1714 → 1928
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    38. XM_017317082.3 → XP_017172571.1  kalirin isoform X44

      UniProtKB/TrEMBL
      D3Z534
      Conserved Domains (5) summary
      cd11853
      Location:594 → 650
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:523 → 575
      Extensin_2; Extensin-like region
      cd13241
      Location:377 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23 → 158
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    39. XM_017317080.3 → XP_017172569.1  kalirin isoform X42

      UniProtKB/TrEMBL
      D3Z534
      Conserved Domains (5) summary
      cd11853
      Location:595 → 651
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:523 → 575
      Extensin_2; Extensin-like region
      cd13241
      Location:377 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23 → 158
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    40. XM_017317081.3 → XP_017172570.1  kalirin isoform X43

      UniProtKB/TrEMBL
      D3Z534
      Conserved Domains (5) summary
      cd11853
      Location:595 → 651
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:524 → 576
      Extensin_2; Extensin-like region
      cd13241
      Location:378 → 512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23 → 159
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    41. XM_017317079.3 → XP_017172568.1  kalirin isoform X41

      UniProtKB/TrEMBL
      D3Z534
      Related
      ENSMUSP00000110615.2, ENSMUST00000114964.8
      Conserved Domains (5) summary
      cd11853
      Location:596 → 652
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:524 → 576
      Extensin_2; Extensin-like region
      cd13241
      Location:378 → 512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23 → 159
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    42. XM_017317076.3 → XP_017172565.1  kalirin isoform X38

      UniProtKB/TrEMBL
      B1B1A7
      Conserved Domains (5) summary
      smart00150
      Location:1121 → 1221
      SPEC; Spectrin repeats
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1270 → 1440
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:886 → 1115
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1447 → 1569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    43. XM_017317075.3 → XP_017172564.1  kalirin isoform X37

      UniProtKB/TrEMBL
      B1B1A7
      Conserved Domains (5) summary
      smart00150
      Location:1130 → 1230
      SPEC; Spectrin repeats
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1279 → 1449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:545 → 761
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1456 → 1578
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    44. XM_006522383.5 → XP_006522446.1  kalirin isoform X36

      UniProtKB/TrEMBL
      B1B1A7
      Conserved Domains (5) summary
      smart00150
      Location:1134 → 1234
      SPEC; Spectrin repeats
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1283 → 1453
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1128
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1460 → 1582
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    45. XM_011245968.4 → XP_011244270.1  kalirin isoform X34

      UniProtKB/TrEMBL
      B1B1A7
      Conserved Domains (6) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      smart00516
      Location:47 → 185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1292 → 1462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:899 → 1137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1469 → 1591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      TIGR02168
      Location:753 → 999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    46. XM_006522382.5 → XP_006522445.1  kalirin isoform X35

      UniProtKB/TrEMBL
      B1B1A7
      Related
      ENSMUSP00000087084.6, ENSMUST00000089655.12
      Conserved Domains (5) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    RNA

    1. XR_001781845.2 RNA Sequence

    2. XR_001781844.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2CG49.1 GenPept UniProtKB/Swiss-Prot:A2CG49

    Gene LinkOut

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