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    Bcas1 brain enriched myelin associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bcas1provided by MGI
    Official Full Name
    brain enriched myelin associated protein 1provided by MGI
    Primary source
    MGI:MGI:1924210
    See related
    Ensembl:ENSMUSG00000013523 AllianceGenome:MGI:1924210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NABC1; 2210416M21Rik; 9030223A09Rik
    Summary
    Predicted to enable protein homodimerization activity. Involved in myelination. Predicted to be located in cytosol. Predicted to be active in synapse. Orthologous to human BCAS1 (brain enriched myelin associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 42.9), cortex adult (RPKM 25.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcas1 in Genome Data Viewer
    Location:
    2 H3; 2 91.41 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170188911..170270292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170343973..170427911, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1017 Neighboring gene predicted gene, 34542 Neighboring gene predicted gene, 39999 Neighboring gene brain enriched myelin associated protein 1, opposite strand 2 Neighboring gene brain enriched myelin associated protein 1, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_06529 Neighboring gene predicted gene 14269 Neighboring gene predicted gene, 34608

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the novel amplified in breast cancer-1 (NABC1) gene product. Beardsley DI, et al. Exp Cell Res, 2003 Nov 1. PMID 14567997
    2. Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity. Lauridsen JB, et al. Neurosci Res, 2011 Jul. PMID 21514331
    3. Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Ishimoto T, et al. Glia, 2017 May. PMID 28230289
    4. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Fard MK, et al. Sci Transl Med, 2017 Dec 6. PMID 29212715, Free PMC Article
    5. PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development. Waldhauser V, et al. Cells, 2023 Jun 6. PMID 37371026, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. that the loss of BCAS1 specifically induced hypomyelination and the expression of inflammation-related genes in the brain
      Title: Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain.
    2. Two transcripts with regulation from days 7 to 28 in the 1-methyl-4-phenyl-tetrahydropyridine treated groups, are identified: brain specific angiogenesis inhibitor associated protein 3 (Baiap3) and breast carcinoma amplified sequence 1 (Bcas1).
      Title: Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    breast carcinoma-amplified sequence 1 homolog
    Names
    amplified in breast cancer 1
    breast carcinoma amplified sequence 1
    novel amplified in breast cancer 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164369.1 → NP_001157841.1  breast carcinoma-amplified sequence 1 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL928812, AL935134
      Consensus CDS
      CCDS50806.1
      UniProtKB/TrEMBL
      E9Q8Q5, Q14CE2
      Related
      ENSMUSP00000104780.3, ENSMUST00000109152.9
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional

    2. NM_029815.2 → NP_084091.2  breast carcinoma-amplified sequence 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_084091.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008957, AL928812, AL935134, BY720653
      Consensus CDS
      CCDS17121.1
      UniProtKB/Swiss-Prot
      A2AVX2, Q80YN3, Q9CVA1
      UniProtKB/TrEMBL
      Q14CE2
      Related
      ENSMUSP00000013667.3, ENSMUST00000013667.3
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      170188911..170270292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252201.2 → XP_030108061.1  breast carcinoma-amplified sequence 1 homolog isoform X13

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    2. XM_030252199.2 → XP_030108059.1  breast carcinoma-amplified sequence 1 homolog isoform X11

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    3. XM_017319334.2 → XP_017174823.1  breast carcinoma-amplified sequence 1 homolog isoform X12

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    4. XM_036162697.1 → XP_036018590.1  breast carcinoma-amplified sequence 1 homolog isoform X5

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    5. XM_017319333.2 → XP_017174822.1  breast carcinoma-amplified sequence 1 homolog isoform X10

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    6. XM_017319331.2 → XP_017174820.1  breast carcinoma-amplified sequence 1 homolog isoform X7

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    7. XM_036162696.1 → XP_036018589.1  breast carcinoma-amplified sequence 1 homolog isoform X3

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    8. XM_030252198.2 → XP_030108058.1  breast carcinoma-amplified sequence 1 homolog isoform X1

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    9. XM_006500387.3 → XP_006500450.1  breast carcinoma-amplified sequence 1 homolog isoform X9

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    10. XM_017319330.2 → XP_017174819.1  breast carcinoma-amplified sequence 1 homolog isoform X6

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    11. XM_017319332.2 → XP_017174821.1  breast carcinoma-amplified sequence 1 homolog isoform X8

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    12. XM_017319329.3 → XP_017174818.1  breast carcinoma-amplified sequence 1 homolog isoform X4

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau

    13. XM_036162695.1 → XP_036018588.1  breast carcinoma-amplified sequence 1 homolog isoform X2

      UniProtKB/TrEMBL
      Q14CE2
      Conserved Domains (1) summary
      PRK12323
      Location:82 → 275
      PRK12323; DNA polymerase III subunit gamma/tau
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YN3.3 GenPept UniProtKB/Swiss-Prot:Q80YN3

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