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    Ptp4a2 protein tyrosine phosphatase 4a2 [ Mus musculus (house mouse) ]

    Gene ID: 19244, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptp4a2provided by MGI
    Official Full Name
    protein tyrosine phosphatase 4a2provided by MGI
    Primary source
    MGI:MGI:1277117
    See related
    Ensembl:ENSMUSG00000028788 AllianceGenome:MGI:1277117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prl-2
    Summary
    Enables enzyme inhibitor activity. Predicted to be involved in protein dephosphorylation. Is active in cytosol. Is expressed in genitourinary system and heart. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 35.0), CNS E11.5 (RPKM 30.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptp4a2 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.38 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129704982..129743800)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129811165..129850003)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene STARR-seq mESC enhancer starr_11505 Neighboring gene STARR-seq mESC enhancer starr_11507 Neighboring gene STARR-positive B cell enhancer mm9_chr4:129438194-129438495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129439040-129439227 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129449340-129449541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129449548-129449839 Neighboring gene predicted gene 12967 Neighboring gene STARR-positive B cell enhancer ABC_E4671 Neighboring gene STARR-seq mESC enhancer starr_11508 Neighboring gene STARR-positive B cell enhancer ABC_E2715 Neighboring gene STARR-seq mESC enhancer starr_11510 Neighboring gene STARR-positive B cell enhancer ABC_E11257 Neighboring gene STARR-positive B cell enhancer ABC_E6225 Neighboring gene STARR-seq mESC enhancer starr_11511 Neighboring gene RIKEN cDNA 1700108I11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7993 Neighboring gene STARR-positive B cell enhancer ABC_E6226 Neighboring gene predicted gene, 23845

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. Du X, et al. Nat Commun, 2024 Jan 29. PMID 38286811, Free PMC Article
    2. PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Kobayashi M, et al. Stem Cells, 2014 Jul. PMID 24753135, Free PMC Article
    3. PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms. Uetani N, et al. JCI Insight, 2017 Jul 6. PMID 28679948, Free PMC Article
    4. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS. Yin C, et al. Front Immunol, 2018. PMID 30483267, Free PMC Article
    5. PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling. Poulet M, et al. Commun Biol, 2020 Oct 23. PMID 33097786, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.
      Title: Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.
    2. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury.
      Title: PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury.
    3. PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
      Title: PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
    4. CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis.
      Title: CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis.
    5. PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
      Title: PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
    6. PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling.
      Title: PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling.
    7. Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
      Title: Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
    8. PRL2 binds to GTPase Rac.
      Title: PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.
    9. a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported.
      Title: Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors.
    10. Oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter.
      Title: The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102154, MGC103400

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase type IVA 2
    Names
    protein-tyrosine phosphatase of regenerating liver 2
    NP_001158217.1
    NP_001411752.1
    NP_001411753.1
    NP_001411754.1
    NP_001411755.1
    NP_001411756.1
    NP_033000.1
    XP_017175534.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164745.2 → NP_001158217.1  protein tyrosine phosphatase type IVA 2 isoform 1

      See identical proteins and their annotated locations for NP_001158217.1

      Status: VALIDATED

      Source sequence(s)
      AL669834
      Consensus CDS
      CCDS18704.1
      UniProtKB/Swiss-Prot
      O70274, Q3U1K7
      UniProtKB/TrEMBL
      Q3UXF9
      Related
      ENSMUSP00000125901.2, ENSMUST00000165853.2
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2

    2. NM_001424823.1 → NP_001411752.1  protein tyrosine phosphatase type IVA 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669834
      UniProtKB/Swiss-Prot
      O70274, Q3U1K7

    3. NM_001424824.1 → NP_001411753.1  protein tyrosine phosphatase type IVA 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669834
      UniProtKB/Swiss-Prot
      O70274, Q3U1K7

    4. NM_001424825.1 → NP_001411754.1  protein tyrosine phosphatase type IVA 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669834

    5. NM_001424826.1 → NP_001411755.1  protein tyrosine phosphatase type IVA 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669834

    6. NM_001424827.1 → NP_001411756.1  protein tyrosine phosphatase type IVA 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669834

    7. NM_008974.5 → NP_033000.1  protein tyrosine phosphatase type IVA 2 isoform 1

      See identical proteins and their annotated locations for NP_033000.1

      Status: VALIDATED

      Source sequence(s)
      AL669834
      Consensus CDS
      CCDS18704.1
      UniProtKB/Swiss-Prot
      O70274, Q3U1K7
      UniProtKB/TrEMBL
      Q3UXF9
      Related
      ENSMUSP00000030578.8, ENSMUST00000030578.14
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2

    RNA

    1. NR_188949.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL669834

    2. NR_188950.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL669834

    3. NR_188951.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL669834

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129704982..129743800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320045.3 → XP_017175534.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O70274, Q3U1K7
      UniProtKB/TrEMBL
      Q3UXF9
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70274.1 GenPept UniProtKB/Swiss-Prot:O70274

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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