Ap2b1 adaptor related protein complex 2 subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ap2b1provided by RGD
Full Name: adaptor related protein complex 2 subunit beta 1provided by RGD
Primary source: RGD:71048
See related: EnsemblRapid:ENSRNOG00000061543 AllianceGenome:RGD:71048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables clathrin binding activity. Involved in several processes, including clathrin coat assembly; positive regulation of endocytosis; and postsynaptic neurotransmitter receptor internalization. Part of clathrin coat. Is active in glutamatergic synapse; postsynaptic endocytic zone; and synaptic vesicle. Is extrinsic component of presynaptic endocytic zone membrane. Biomarker of middle cerebral artery infarction. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 391.0), Brain (RPKM 322.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (68596925..68702547)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (68099397..68205023)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (70516462..70621973)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARH protein has an AP-2 beta2 appendage-binding sequence
Title: Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Chm188 (e-PCR)
- UniSTS:518406

UniSTS:259407 (e-PCR)
- UniSTS:259407

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:259407

D10Mco43 (e-PCR)
- UniSTS:240222

D10Mco87 (e-PCR)
- UniSTS:519017

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:506731

D10Chm187 (e-PCR)
- UniSTS:518253

D10Chm146 (e-PCR)
- UniSTS:518262

Ap2b1 (e-PCR), detects polymorphism
- UniSTS:527250

D10Chm189 (e-PCR)
- UniSTS:518034

SHGC-57242 (e-PCR)
- UniSTS:43411

D10Chm192 (e-PCR)
- UniSTS:518048

D11Pas17 (e-PCR), detects polymorphism
- UniSTS:209579

D10Chm120 (e-PCR)
- UniSTS:518326

D10Chm147 (e-PCR)
- UniSTS:518072

RH127319 (e-PCR)
- UniSTS:210629

D10Chm245 (e-PCR)
- UniSTS:518343

D10Chm191 (e-PCR)
- UniSTS:518383

D10Chm190 (e-PCR)
- UniSTS:518135

AU046825 (e-PCR)
- UniSTS:111100

AP2B1-1 (e-PCR)
- UniSTS:509951

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	ISO Inferred from Sequence Orthology more info
part_of AP-type membrane coat adaptor complex	TAS Traceable Author Statement more info	PubMed
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
part_of clathrin adaptor complex	ISO Inferred from Sequence Orthology more info
part_of clathrin coat	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of presynaptic endocytic zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of presynaptic endocytic zone membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in postsynaptic endocytic zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AP-2 complex subunit beta

Names: AP-1 complex subunit beta-1-like; AP-2 complex subunit beta-like; AP105B; adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; beta-2-adaptin; beta-adaptin; beta2-adaptin; clathrin assembly protein complex 2 beta large chain; plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080583.2 → NP_542150.1 AP-2 complex subunit beta

See identical proteins and their annotated locations for NP_542150.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

68596925..68702547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767937.4 → XP_008766159.1 AP-2 complex subunit beta isoform X1

See identical proteins and their annotated locations for XP_008766159.1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_063268347.1 → XP_063124417.1 AP-2 complex subunit beta isoform X2

UniProtKB/Swiss-Prot

P62944

UniProtKB/TrEMBL

A0A8L2R7J3, A6HHH4
XM_017596973.3 → XP_017452462.1 AP-2 complex subunit beta isoform X1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_063268345.1 → XP_063124415.1 AP-2 complex subunit beta isoform X2

UniProtKB/Swiss-Prot

P62944

UniProtKB/TrEMBL

A0A8L2R7J3, A6HHH4
XM_008767938.3 → XP_008766160.1 AP-2 complex subunit beta isoform X1

See identical proteins and their annotated locations for XP_008766160.1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_008767936.4 → XP_008766158.1 AP-2 complex subunit beta isoform X1

See identical proteins and their annotated locations for XP_008766158.1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97

Conserved Domains (4) summary

smart00809
Location:731 → 831

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:840 → 950

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_063268346.1 → XP_063124416.1 AP-2 complex subunit beta isoform X2

UniProtKB/Swiss-Prot

P62944

UniProtKB/TrEMBL

A0A8L2R7J3, A6HHH4

Related

ENSRNOP00000073619.3, ENSRNOT00000090446.3
XM_008767939.4 → XP_008766161.1 AP-2 complex subunit beta isoform X2

See identical proteins and their annotated locations for XP_008766161.1

UniProtKB/Swiss-Prot

P62944

UniProtKB/TrEMBL

A0A8L2R7J3, A6HHH4

Conserved Domains (4) summary

smart00809
Location:717 → 817

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:826 → 936

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region
XM_063268342.1 → XP_063124412.1 AP-2 complex subunit beta isoform X1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97

Related

ENSRNOP00000070905.1, ENSRNOT00000088198.3
XM_063268348.1 → XP_063124418.1 AP-2 complex subunit beta isoform X2

UniProtKB/Swiss-Prot

P62944

UniProtKB/TrEMBL

A0A8L2R7J3, A6HHH4

Related

ENSRNOP00000072290.3, ENSRNOT00000085799.3
XM_063268350.1 → XP_063124420.1 AP-2 complex subunit beta isoform X3

UniProtKB/TrEMBL

A0A8L2R623
XM_063268349.1 → XP_063124419.1 AP-2 complex subunit beta isoform X2

UniProtKB/Swiss-Prot

P62944

UniProtKB/TrEMBL

A0A8L2R7J3, A6HHH4
XM_063268343.1 → XP_063124413.1 AP-2 complex subunit beta isoform X1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97
XM_063268344.1 → XP_063124414.1 AP-2 complex subunit beta isoform X1

UniProtKB/TrEMBL

A0A8L2R7J3, Q3ZB97