Adora2a adenosine A2a receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adora2aprovided by MGI
Official Full Name: adenosine A2a receptorprovided by MGI
Primary source: MGI:MGI:99402
See related: Ensembl:ENSMUSG00000020178 AllianceGenome:MGI:99402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A2aR; A2AAR; AA2AR; ARA2A
Summary: Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled adenosine receptor signaling pathway. Acts upstream of or within several processes, including chemical synaptic transmission; positive regulation of cell communication; and response to amphetamine. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; intestine; and liver and biliary system. Used to study myopia and primary pulmonary hypertension. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 8.8), spleen adult (RPKM 8.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75152711..75170626)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75316877..75334792)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective role of the CD73-A2AR axis in cirrhotic cardiomyopathy through negative feedback regulation of the NF-kappaB pathway.
Title: Protective role of the CD73-A2AR axis in cirrhotic cardiomyopathy through negative feedback regulation of the NF-κB pathway.
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma.
Title: Nociceptive adenosine A(2A) receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma.
Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals.
Title: Feedback facilitation by adenosine A(2A) receptors of ATP release from mouse hippocampal nerve terminals.
ADENOSINE INFLUENCES FOXP3 EXPRESSION OF T REGS VIA THE A2AR/CREB PATHWAY IN A MOUSE MODEL OF SEPSIS.
Title: ADENOSINE INFLUENCES FOXP3 EXPRESSION OF T REGS VIA THE A2AR/CREB PATHWAY IN A MOUSE MODEL OF SEPSIS.
Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
Title: Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury.
Title: Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury.
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses.
Title: A(2A)R eGFP reporter mouse enables elucidation of A(2A)R expression dynamics during anti-tumor immune responses.
Cardiovascular and respiratory evaluation in adenosine A2A receptor knockout mice submitted to short-term sustained hypoxia.
Title: Cardiovascular and respiratory evaluation in adenosine A(2A) receptor knockout mice submitted to short-term sustained hypoxia.
Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer's disease by promoting synaptic plasticity of adult-born granule cells.
Title: Blockade of adenosine A(2A) receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer's disease by promoting synaptic plasticity of adult-born granule cells.
Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Abeta1-42 to Model Early Alzheimer's Disease.
Title: Adenosine A(2A) Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ(1-42) to Model Early Alzheimer's Disease.

Submit: New GeneRIF Correction See all GeneRIFs (285)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (6) 1 citation

General gene information

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Markers

Adora2a (e-PCR), detects polymorphism
- UniSTS:141041

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled adenosine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	IEA Inferred from Electronic Annotation more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables type 5 metabotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables type 5 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled adenosine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte activation	IEA Inferred from Electronic Annotation more info
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eating behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of alpha-beta T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, sleep	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	IEA Inferred from Electronic Annotation more info
involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of norepinephrine secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in response to alkaloid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to caffeine	IEA Inferred from Electronic Annotation more info
involved_in response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, dopaminergic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in asymmetric synapse	IEA Inferred from Electronic Annotation more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine receptor A2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331095.2 → NP_001318024.1 adenosine receptor A2a isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AC137067

Consensus CDS

CCDS23924.1

UniProtKB/Swiss-Prot

Q2NLC1, Q60613

Conserved Domains (1) summary

cd15068
Location:4 → 294

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001331096.2 → NP_001318025.1 adenosine receptor A2a isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AC137067

Consensus CDS

CCDS23924.1

UniProtKB/Swiss-Prot

Q2NLC1, Q60613

Conserved Domains (1) summary

cd15068
Location:4 → 294

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001428349.1 → NP_001415278.1 adenosine receptor A2a isoform a

Status: VALIDATED

Source sequence(s)

AC137067

UniProtKB/Swiss-Prot

Q2NLC1, Q60613
NM_001428350.1 → NP_001415279.1 adenosine receptor A2a isoform b

Status: VALIDATED

Source sequence(s)

AC137067
NM_001428351.1 → NP_001415280.1 adenosine receptor A2a isoform b

Status: VALIDATED

Source sequence(s)

AC137067
NM_001428352.1 → NP_001415281.1 adenosine receptor A2a isoform b

Status: VALIDATED

Source sequence(s)

AC137067
NM_001428353.1 → NP_001415282.1 adenosine receptor A2a isoform b

Status: VALIDATED

Source sequence(s)

AC137067
NM_009630.4 → NP_033760.2 adenosine receptor A2a isoform a

See identical proteins and their annotated locations for NP_033760.2

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variants 2-4, encodes the longer isoform (a).

Source sequence(s)

AC137067

Consensus CDS

CCDS23924.1

UniProtKB/Swiss-Prot

Q2NLC1, Q60613

Related

ENSMUSP00000101060.2, ENSMUST00000105420.3

Conserved Domains (1) summary

cd15068
Location:4 → 294

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

75152711..75170626

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244829.2 → XP_030100689.1 adenosine receptor A2a isoform X2

Conserved Domains (2) summary

cd14964
Location:3 → 21

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:2 → 179

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006513093.5 → XP_006513156.1 adenosine receptor A2a isoform X1

Conserved Domains (1) summary

cd15068
Location:4 → 294

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036155515.1 → XP_036011408.1 adenosine receptor A2a isoform X2

Conserved Domains (2) summary

cd14964
Location:3 → 21

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:2 → 179

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily