CG13623 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG13623provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0039205
Locus tag: Dmel_CG13623
See related: AllianceGenome:FB:FBgn0039205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH27470; Dmel\CG13623; IscA2
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in mitochondrial matrix. Predicted to be part of mitochondrial [4Fe-4S] assembly complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24529773..24530558, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20355495..20356280, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by [4Fe-4S] cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by iron-sulfur cluster transfer	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation by iron-sulfur cluster transfer	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of mitochondrial [4Fe-4S] assembly complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	NAS Non-traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

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