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    Lima1 LIM domain and actin binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lima1provided by RGD
    Official Full Name
    LIM domain and actin binding 1provided by RGD
    Primary source
    RGD:1564050
    See related
    EnsemblRapid:ENSRNOG00000059801 AllianceGenome:RGD:1564050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    eplin
    Summary
    Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; intestinal cholesterol absorption; and negative regulation of actin filament depolymerization. Predicted to be located in several cellular components, including brush border membrane; focal adhesion; and stress fiber. Predicted to be active in actin cytoskeleton and plasma membrane. Orthologous to human LIMA1 (LIM domain and actin binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 113.9), Spleen (RPKM 105.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lima1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132780556..132880343, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130901717..131001512, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141428113..141528447, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor COX14 Neighboring gene ceramide synthase 5 Neighboring gene uncharacterized LOC134479573 Neighboring gene uncharacterized LOC134479574 Neighboring gene uncharacterized LOC102549417 Neighboring gene family with sequence similarity 186 member A Neighboring gene La ribonucleoprotein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN. Han MY, et al. Mol Cell Biol, 2007 Dec. PMID 17875928, Free PMC Article
    2. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. Maul RS, et al. J Cell Biol, 2003 Feb 3. PMID 12566430, Free PMC Article
    3. EPLIN, epithelial protein lost in neoplasm. Maul RS, et al. Oncogene, 1999 Dec 16. PMID 10618726
    4. Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells. Tsurumi H, et al. Kidney Int, 2014 Sep. PMID 24694988
    5. Characterization of mouse epithelial protein lost in neoplasm (EPLIN) and comparison of mammalian and zebrafish EPLIN. Maul RS, et al. Gene, 2001 Jan 10. PMID 11179679

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intestinal cholesterol absorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intestinal cholesterol absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ruffle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ruffle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    LIM domain and actin-binding protein 1
    Names
    epithelial protein lost in neoplasm

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191615.3 → NP_001178544.1  LIM domain and actin-binding protein 1

      See identical proteins and their annotated locations for NP_001178544.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      F1LR10, G3V8I6
      Related
      ENSRNOP00000072604.1, ENSRNOT00000091702.3
      Conserved Domains (1) summary
      cd09485
      Location:388 → 440
      LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132780556..132880343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257354.5 → XP_006257416.1  LIM domain and actin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM55
      Related
      ENSRNOP00000096626.1, ENSRNOT00000109357.2
      Conserved Domains (1) summary
      cd09485
      Location:406 → 458
      LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LR10.2 GenPept UniProtKB/Swiss-Prot:F1LR10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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