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    Akap7 A kinase anchor protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 432442, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Akap7provided by MGI
    Official Full Name
    A kinase anchor protein 7provided by MGI
    Primary source
    MGI:MGI:1859150
    See related
    Ensembl:ENSMUSG00000039166 AllianceGenome:MGI:1859150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AKAP15; Akap18; 6430401D08
    Summary
    Enables protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Located in nucleus. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including brain; cartilage; endocrine gland; genitourinary system; and trachea. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 6.0), CNS E18 (RPKM 4.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Akap7 in Genome Data Viewer
    Location:
    10 A4; 10 12.26 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (25044988..25175115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (25169090..25299217, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 36313 Neighboring gene STARR-seq mESC enhancer starr_26094 Neighboring gene STARR-seq mESC enhancer starr_26095 Neighboring gene STARR-seq mESC enhancer starr_26096 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene, 25016 Neighboring gene STARR-seq mESC enhancer starr_26098 Neighboring gene predicted gene, 40617 Neighboring gene STARR-seq mESC enhancer starr_26101 Neighboring gene erythrocyte membrane protein band 4.1 like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:25123932-25124041 Neighboring gene small leucine-rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes. Chen S, et al. Biochem Biophys Res Commun, 2015 May 22. PMID 25849890
    2. A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. Hulme JT, et al. J Biol Chem, 2002 Feb 8. PMID 11733497
    3. Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations. Hellman K, et al. Sleep, 2010 Jan. PMID 20120617, Free PMC Article
    4. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. Cheng Q, et al. J Neurosci, 2014 Jan 1. PMID 24381273, Free PMC Article
    5. Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. Fu Y, et al. J Biol Chem, 2011 Apr 8. PMID 21216955, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Requirement of the Ca(2+) channel beta2 subunit for sympathetic PKA phosphorylation.
      Title: Requirement of the Ca(2+) channel β(2) subunit for sympathetic PKA phosphorylation.
    2. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
      Title: Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
    3. The results demonstrate that green tea catechins enhance lipolysis in the presence of norepinephrine via a PKA-dependent pathway in 3T3-L1 adipocytes, providing a potential mechanism by which green tea catechins could reduce body fat.
      Title: Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes.
    4. Protein kinase A activation enhances hippocampal mossy fiber glutamatergic transmission.
      Title: Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.
    5. AKAP7 is not required for regulation of Ca(2+) handling in mouse cardiomyocytes.
      Title: Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
    6. AKAP15 co-immunoprecipitates with CaV1.2 and CaV1.3 channels. AKAP15 has overlapping localization with CaV1.2 and CaV1.3 channels in cell bodies and proximal dendrites and is closely co-localized with CaV1.2 channels in punctate clusters.
      Title: Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.
    7. CaV1.2 channels in DCT-/- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized expression of AKAP15 is reduced
      Title: Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.
    8. Alterations in cortical synaptic receptors, impairments in sleep continuity, and alterations in sleep oscillations in R(AB) mice imply that PKA is involved not only in synaptic plasticity and memory storage but also in the regulation of sleep/wake states.
      Title: Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations.
    9. AKAP7gamma is the first nuclear AKAP to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes
      Title: AKAP7gamma is a nuclear RI-binding AKAP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 7
    Names
    A kinase (PRKA) anchor protein 7
    A-kinase anchor protein 18
    A-kinase anchor protein 9 kDa
    AKAP 9
    AKAP-18
    protein kinase A anchoring protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347460.2 → NP_001334389.1  A-kinase anchor protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153549
      Consensus CDS
      CCDS83688.1
      UniProtKB/Swiss-Prot
      G3X9Q5, O55074
      Related
      ENSMUSP00000097590.3, ENSMUST00000100012.3
      Conserved Domains (1) summary
      pfam10470
      Location:23 → 79
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

    2. NM_001379238.1 → NP_001366167.1  A-kinase anchor protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC153549, AC153550
      UniProtKB/Swiss-Prot
      F8VQ58, Q7TN79
      Conserved Domains (2) summary
      pfam10470
      Location:256 → 311
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    3. NM_001379239.1 → NP_001366168.1  A-kinase anchor protein 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AC153549, AC153550
      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    4. NM_001379240.1 → NP_001366169.1  A-kinase anchor protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153550
      UniProtKB/TrEMBL
      Q4KL21
      Related
      ENSMUSP00000093455.5, ENSMUST00000095779.11

    5. NM_018747.5 → NP_061217.3  A-kinase anchor protein 7 isoform 1

      See identical proteins and their annotated locations for NP_061217.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 3, encodes isoform 1.
      Source sequence(s)
      AC153549, AC153550
      Consensus CDS
      CCDS23753.1
      UniProtKB/Swiss-Prot
      F8VQ58, Q7TN79
      Related
      ENSMUSP00000043624.8, ENSMUST00000041984.14
      Conserved Domains (2) summary
      pfam10470
      Location:256 → 311
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RNA

    1. NR_166567.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153549, AC153550

    2. NR_166568.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153549, AC153550

    3. NR_166569.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153549

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      25044988..25175115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512788.4 → XP_006512851.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512851.1

      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    2. XM_030245157.2 → XP_030101017.1  A-kinase anchor protein 7 isoform X3

      UniProtKB/Swiss-Prot
      F8VQ58, Q7TN79
      Conserved Domains (2) summary
      pfam10470
      Location:256 → 311
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    3. XM_030245156.1 → XP_030101016.1  A-kinase anchor protein 7 isoform X2

      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    4. XM_006512790.3 → XP_006512853.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512853.1

      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    5. XM_036155887.1 → XP_036011780.1  A-kinase anchor protein 7 isoform X2

      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    6. XM_006512789.2 → XP_006512852.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512852.1

      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    7. XM_006512791.5 → XP_006512854.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512854.1

      Conserved Domains (1) summary
      pfam10469
      Location:51 → 249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    8. XM_006512793.5 → XP_006512856.1  A-kinase anchor protein 7 isoform X4

      See identical proteins and their annotated locations for XP_006512856.1

      Conserved Domains (1) summary
      pfam10469
      Location:6 → 164
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    9. XM_006512794.5 → XP_006512857.1  A-kinase anchor protein 7 isoform X4

      See identical proteins and their annotated locations for XP_006512857.1

      Conserved Domains (1) summary
      pfam10469
      Location:6 → 164
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    10. XM_017314023.3 → XP_017169512.1  A-kinase anchor protein 7 isoform X5

      Conserved Domains (1) summary
      pfam10470
      Location:46 → 102
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

    11. XM_036155886.1 → XP_036011779.1  A-kinase anchor protein 7 isoform X1

      Conserved Domains (1) summary
      pfam10469
      Location:187 → 385
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RNA

    1. XR_001779549.3 RNA Sequence

    2. XR_003948725.2 RNA Sequence

    3. XR_001779547.3 RNA Sequence

    4. XR_001779546.3 RNA Sequence

    5. XR_380068.5 RNA Sequence

    6. XR_380067.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55074.4 GenPept UniProtKB/Swiss-Prot:O55074
    Q7TN79.2 GenPept UniProtKB/Swiss-Prot:Q7TN79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools