Scg5 secretogranin V [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scg5provided by RGD
Official Full Name: secretogranin Vprovided by RGD
Primary source: RGD:3669
See related: EnsemblRapid:ENSRNOG00000007542 AllianceGenome:RGD:3669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 7B2; Sgne1
Summary: Predicted to enable enzyme inhibitor activity and unfolded protein binding activity. Predicted to be involved in intracellular protein transport; peptide hormone processing; and regulation of hormone secretion. Predicted to be located in secretory granule. Predicted to be active in nucleus. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1374.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (120998420..121042881, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (100544101..100588558, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (105235065..105279475, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute exposure of MIN6 cells transduced with rat 7B2 to high glucose increased endogenous 7B2 biosynthesis without affecting the levels of its mRNA.
Title: Regulation of 7B2 mRNA translation: dissecting the role of its 5'-untranslated region.
phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP, which impairs its ability to bind substrate
Title: Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuroendocrine protein 7B2

Names: Secretory granule neuroendocrine, protein 1 (7B2 protein); secretogranin V (7B2 protein); secretogranin-5; secretory granule endocrine protein I; secretory granule neuroendocrine protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013175.4 → NP_037307.2 neuroendocrine protein 7B2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P27682

UniProtKB/TrEMBL

A6HP67, G3V714

Related

ENSRNOP00000010679.5, ENSRNOT00000010679.8

Conserved Domains (1) summary

pfam05281
Location:22 → 197

Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

120998420..121042881 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234701.5 → XP_006234763.1 neuroendocrine protein 7B2 isoform X1

UniProtKB/Swiss-Prot

P27682

Conserved Domains (1) summary

pfam05281
Location:22 → 196

Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)