Ikzf3 IKAROS family zinc finger 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ikzf3provided by MGI
Official Full Name: IKAROS family zinc finger 3provided by MGI
Primary source: MGI:MGI:1342542
See related: Ensembl:ENSMUSG00000018168 AllianceGenome:MGI:1342542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aiolos; Zfpn1a3; Znfn1a3; 5830411O07Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in lymphocyte differentiation; positive regulation of transcription by RNA polymerase II; and regulation of B cell activation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 23.1), spleen adult (RPKM 20.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.75 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98355436..98437157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98464610..98546031, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
Title: Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
Title: Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.
Title: IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes.
Title: The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes.
Impaired tissue homing by the Ikzf3[N159S] variant is mediated by interfering with Ikaros function.
Title: Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function.
Aiolos represses CD4[+] T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Title: Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity.
IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation.
Title: IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation.
AIOLOS Variants Causing Immunodeficiency in Human and Mice.
Title: AIOLOS Variants Causing Immunodeficiency in Human and Mice.
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Title: Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Aiolos regulates eosinophil migration into tissues.
Title: Aiolos regulates eosinophil migration into tissues.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Znfn1a3 (e-PCR), detects polymorphism
- UniSTS:225841

BB356608 (e-PCR)
- UniSTS:208743

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein Aiolos

Names: ikaros family zinc finger protein 3; zinc finger protein, subfamily 1A, 3 (Aiolos)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011771.1 → NP_035901.1 zinc finger protein Aiolos

See identical proteins and their annotated locations for NP_035901.1

Status: VALIDATED

Source sequence(s)

AF001293, AI019346, AI549961, AK036657, AK038043, BE457553

Consensus CDS

CCDS25352.1

UniProtKB/Swiss-Prot

B1AQE6, O08900

Related

ENSMUSP00000099430.4, ENSMUST00000103141.4

Conserved Domains (3) summary

COG5048
Location:105 → 218

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98355436..98437157 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533204.5 → XP_006533267.1 zinc finger protein Aiolos isoform X1

Conserved Domains (2) summary

COG5048
Location:87 → 200

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:101 → 121

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006533206.5 → XP_006533269.1 zinc finger protein Aiolos isoform X3
XM_006533205.5 → XP_006533268.1 zinc finger protein Aiolos isoform X2