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    Cnga4 cyclic nucleotide gated channel alpha 4 [ Mus musculus (house mouse) ]

    Gene ID: 233649, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cnga4provided by MGI
    Official Full Name
    cyclic nucleotide gated channel alpha 4provided by MGI
    Primary source
    MGI:MGI:2664099
    See related
    Ensembl:ENSMUSG00000030897 AllianceGenome:MGI:2664099
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OCNC2
    Summary
    Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Acts upstream of or within sensory perception of smell. Located in non-motile cilium membrane. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.1), cortex adult (RPKM 0.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnga4 in Genome Data Viewer
    Location:
    7 E3; 7 55.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105049247..105057981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105400024..105408775)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene predicted gene 5901 Neighboring gene STARR-positive B cell enhancer ABC_E4960 Neighboring gene STARR-positive B cell enhancer ABC_E3739 Neighboring gene predicted gene 4972 Neighboring gene cholecystokinin B receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Munger SD, et al. Science, 2001 Dec 7. PMID 11739959, Free PMC Article
    2. Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. Michalakis S, et al. J Biol Chem, 2006 Nov 17. PMID 16980309, Free PMC Article
    3. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Kelliher KR, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12649326, Free PMC Article
    4. Nomenclature for ion channel subunits. Bradley J, et al. Science, 2001 Dec 7. PMID 11764791, Free PMC Article
    5. cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation. Cisneros-Mejorado A, et al. FEBS Lett, 2012 Jan 20. PMID 22192355

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC130316

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cGMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intracellular cyclic nucleotide activated cation channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in non-motile cilium membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated cation channel alpha-4
    Names
    CNG channel alpha-4
    CNG-4
    CNG4
    cyclic nucleotide gated cation channel
    olfactory cyclic nucleotide-gated channel
    olfactory cyclic nucleotide-gated channel subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033317.3 → NP_001028489.1  cyclic nucleotide-gated channel alpha-4

      See identical proteins and their annotated locations for NP_001028489.1

      Status: PROVISIONAL

      Source sequence(s)
      AC125055
      Consensus CDS
      CCDS21650.1
      UniProtKB/Swiss-Prot
      Q08EL1, Q3UW12
      Related
      ENSMUSP00000033187.5, ENSMUST00000033187.6
      Conserved Domains (3) summary
      cd00038
      Location:348 → 464
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:34 → 273
      Ion_trans; Ion transport protein
      pfam16526
      Location:464 → 534
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105049247..105057981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322183.3 → XP_017177672.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

      UniProtKB/Swiss-Prot
      Q08EL1, Q3UW12
      Conserved Domains (3) summary
      cd00038
      Location:348 → 464
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:34 → 273
      Ion_trans; Ion transport protein
      pfam16526
      Location:464 → 534
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    2. XM_030242497.2 → XP_030098357.1  cyclic nucleotide-gated cation channel alpha-4 isoform X2

      Related
      ENSMUSP00000147387.2, ENSMUST00000210344.2
      Conserved Domains (3) summary
      PLN03192
      Location:2 → 361
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:245 → 361
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam16526
      Location:361 → 431
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UW12.1 GenPept UniProtKB/Swiss-Prot:Q3UW12

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