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    baz bazooka [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32703, updated on 2-Nov-2024

    Summary

    Official Symbol
    bazprovided by FlyBase
    Official Full Name
    bazookaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000163
    Locus tag
    Dmel_CG5055
    See related
    AllianceGenome:FB:FBgn0000163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Baz; BAZ; Baz/Par-3; Baz/Par3; Bazooka; CG5055; D-par3; D-Par3; Dmel\CG5055; dPar-3; l(1)G0484; par-3; Par-3; PAR-3; par3; Par3; PAR3
    Summary
    Enables phosphatidic acid binding activity and phosphatidylinositol binding activity. Involved in several processes, including cell junction assembly; generation of neurons; and oogenesis. Located in cytoplasmic side of apical plasma membrane; spot adherens junction; and zonula adherens. Part of PAR polarity complex. Is expressed in several structures, including Malpighian tubule Type II cell; NMJ bouton; chordotonal neurons; germline cell; and somatic cell of ovariole. Used to study developmental disorder of mental health. Orthologous to several human genes including PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See baz in Genome Data Viewer
    Location:
    15F1-15F2; 1-57 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17160006..17200728)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17054039..17094738)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene xmas Neighboring gene long non-coding RNA:CR44026 Neighboring gene Tubulin tyrosine ligase-like 1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: 17167449-17167542 mobile_element_type = transposon:INE-1{}4211

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adherens junction organization HGI PubMed 
    involved_in apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axis elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in border follicle cell delamination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branching involved in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in follicle cell of egg chamber-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ-band extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germarium-derived oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oocyte anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oocyte microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in photoreceptor cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zonula adherens assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PAR polarity complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spot adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in zonula adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    bazooka
    Names
    Baz
    Bazooka-Par3
    Bazooka/Par-3
    Bazooka/Par3
    CG5055-PA
    CG5055-PB
    CG5055-PC
    CG5055-PD
    baz-PA
    baz-PB
    baz-PC
    baz-PD
    par-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17160006..17200728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347807.1NP_001334669.1  bazooka, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96782, Q9VX75
    2. NM_001042818.4NP_001036283.1  bazooka, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96782, Q0KHR3
      Conserved Domains (3) summary
      cd00992
      Location:462548
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:62174
      DUF3534; Domain of unknown function (DUF3534)
      cl00663
      Location:390436
      CRS1_YhbY; CRS1 / YhbY (CRM) domain
    3. NM_001298436.2NP_001285365.1  bazooka, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96782, X2JCB3
      Conserved Domains (3) summary
      cd00992
      Location:462548
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:62174
      DUF3534; Domain of unknown function (DUF3534)
      cl00663
      Location:390436
      CRS1_YhbY; CRS1 / YhbY (CRM) domain
    4. NM_001298435.2NP_001285364.1  bazooka, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96782, X2JFU8
      Conserved Domains (3) summary
      cd00992
      Location:441527
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1153
      DUF3534; Domain of unknown function (DUF3534)
      cl00663
      Location:369415
      CRS1_YhbY; CRS1 / YhbY (CRM) domain