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    Mnn1 Menin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33991, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Mnn1provided by FlyBase
    Official Full Name
    Menin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031885
    Locus tag
    Dmel_CG13778
    See related
    AllianceGenome:FB:FBgn0031885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13778; CG33266; Dmel\CG13778; MEN1; menin; Menin; Menin1; Mnn; mnn1
    Summary
    Predicted to enable Y-form DNA binding activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and regulation of JNK cascade. Located in nucleus. Part of MLL1/2 complex. Is expressed in several structures, including anterior spiracle primordium; anterior-posterior subdivision of organism; and ectoderm. Used to study multiple endocrine neoplasia type 1. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mnn1 in Genome Data Viewer
    Location:
    27D7-27D7; 2-24 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7056301..7063586)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7056301..7063586)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab30 Neighboring gene caper Neighboring gene milton Neighboring gene Male specific transcript 27D Neighboring gene Suppressor of exocyst mutations 1 Neighboring gene Nuf2 Neighboring gene UDP-glycosyltransferase family 307 member A1 Neighboring gene PDGF- and VEGF-related factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Analysis of a Putative Target of Spatially Varying Selection in the Menin1 Gene of Drosophila melanogaster. Svetec N, et al. G3 (Bethesda), 2019 Jan 9. PMID 30404774, Free PMC Article
    2. Animal models of MEN1. Mohr H, et al. Endocr Relat Cancer, 2017 Oct. PMID 28743793
    3. Characterization of a MEN1 ortholog from Drosophila melanogaster. Guru SC, et al. Gene, 2001 Jan 24. PMID 11223240
    4. Fly meets shotgun: shotgun wins. Hartl DL. Nat Genet, 2000 Apr. PMID 10742085
    5. Complementary DNA structure and genomic organization of Drosophila menin. Maruyama K, et al. Mol Cell Endocrinol, 2000 Oct 25. PMID 11064160

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we report the results of our transgenic analysis of this amino acid polymorphism. Genotypes carrying alternative Mnn1 alleles differed in multiple phenotypes in a direction generally consistent with phenotypic differences previously observed along latitudinal clines.
      Title: Functional Analysis of a Putative Target of Spatially Varying Selection in the Menin1 Gene of Drosophila melanogaster.
    2. Data show that menin links the stress response to the control of genome stability.
      Title: Menin links the stress response to genome stability in Drosophila melanogaster.
    3. We observed complex genetic interactions between mnn1 and jun in different developmental settings. Our data support the idea that one function of menin is to modulate Jun activity in a manner dependent on the cellular context.
      Title: Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
    4. Menin has a role in regulating stress response in Drosophila melanogaster
      Title: Menin is a regulator of the stress response in Drosophila melanogaster.
    5. Drosophila Mnn1 mutants have an elevated rate of both sporadic and DNA damage-induced mutations.
      Title: Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Y-form DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G1 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proboscis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL1/2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    menin 1
    Names
    CG13778-PA
    CG13778-PB
    CG13778-PC
    Menin1
    Mnn1-PA
    Mnn1-PB
    Mnn1-PC
    menin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7056301..7063586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042877.2 → NP_001036342.1  menin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KXY9, Q9NKX0, Q9VM47
      Conserved Domains (2) summary
      cd14456
      Location:17 → 464
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:18 → 714
      Menin; Menin

    2. NM_078774.4 → NP_523498.2  menin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523498.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KXY9, Q9NKX0, Q9VM47
      Related
      FBpp0079029
      Conserved Domains (2) summary
      cd14456
      Location:17 → 464
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:18 → 714
      Menin; Menin

    3. NM_164739.3 → NP_723252.2  menin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723252.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPI5, Q8SXU2
      Related
      FBpp0079030
      Conserved Domains (1) summary
      cd14456
      Location:17 → 464
      Menin; Scaffolding protein menin encoded by the MEN1 gene
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KXY9 Q7KXY9
    Q8SXU2 Q8SXU2
    Q9VM47 Q9VM47

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