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    CG1239 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1239provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037368
    Locus tag
    Dmel_CG1239
    See related
    AllianceGenome:FB:FBgn0037368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BCDIN3D; cg1239; Dmel\CG1239
    Summary
    Enables U6 snRNA binding activity. Involved in snRNA methylation. Located in nucleus. Is expressed in organism. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1239 in Genome Data Viewer
    Location:
    83C1-83C1; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5733513..5734702)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1559235..1560424)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene castor Neighboring gene long non-coding RNA:CR44924 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Symplekin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs. Peng Q, et al. Sci Adv, 2023 Dec 15. PMID 38100593, Free PMC Article
    2. RNA methyltransferase BCDIN3D is crucial for female fertility and miRNA and mRNA profiles in Drosophila ovaries. Zhu L, et al. PLoS One, 2019. PMID 31145769, Free PMC Article
    3. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Tatomer DC, et al. Nucleus, 2014. PMID 25493544, Free PMC Article
    4. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. Herold A, et al. EMBO J, 2003 May 15. PMID 12743041, Free PMC Article
    5. Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Rehwinkel J, et al. Nat Struct Mol Biol, 2004 Jun. PMID 15133499

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U6 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1239-PA
    CG1239-PB
    CG1239-PC
    NP_001287185.1
    NP_001287186.1
    NP_649577.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5733513..5734702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300256.1 → NP_001287185.1  uncharacterized protein Dmel_CG1239, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ANN6, A0ANP4, C0MJ20, C0MJ21, Q9VNH1
      UniProtKB/TrEMBL
      A0A0B4LGT7
      Conserved Domains (2) summary
      pfam06859
      Location:191 → 299
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:109 → 233
      Methyltransf_18; Methyltransferase domain

    2. NM_001300257.1 → NP_001287186.1  uncharacterized protein Dmel_CG1239, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ANN6, A0ANP4, C0MJ20, C0MJ21, Q9VNH1
      UniProtKB/TrEMBL
      A0A0B4LGT7
      Conserved Domains (2) summary
      pfam06859
      Location:191 → 299
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:109 → 233
      Methyltransf_18; Methyltransferase domain

    3. NM_141320.3 → NP_649577.1  uncharacterized protein Dmel_CG1239, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ANN6, A0ANP4, C0MJ20, C0MJ21, Q9VNH1
      UniProtKB/TrEMBL
      A0A0B4LGT7
      Related
      FBpp0078369
      Conserved Domains (2) summary
      pfam06859
      Location:191 → 299
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:109 → 233
      Methyltransf_18; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGT7 A0A0B4LGT7
    Q9VNH1.2 Q9VNH1

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