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    LPAR1 lysophosphatidic acid receptor 1 [ Ovis aries (sheep) ]

    Gene ID: 443346, updated on 10-Oct-2024

    Summary

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    Gene symbol
    LPAR1
    Gene description
    lysophosphatidic acid receptor 1
    See related
    EnsemblRapid:ENSOARG00020000672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    EDG-2
    Orthologs
    human mouse all
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    Genomic context

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    See LPAR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (12384522..12548433)

    Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene uncharacterized LOC114112928 Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene uncharacterized LOC121818589 Neighboring gene muscle associated receptor tyrosine kinase Neighboring gene uncharacterized LOC121818590 Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a new member of the G-protein coupled receptor EDG family. Masana MI, et al. Recept Channels, 1995. PMID 8833998
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lysophosphatidic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 1
    Names
    LPA receptor 1
    LPA-1
    endothelium differentiation gene 2
    lysophosphatidic acid receptor Edg-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009332.1 → NP_001009332.1  lysophosphatidic acid receptor 1

      See identical proteins and their annotated locations for NP_001009332.1

      Status: PROVISIONAL

      Source sequence(s)
      U18405
      UniProtKB/Swiss-Prot
      P46628
      UniProtKB/TrEMBL
      W5P9Y0
      Conserved Domains (1) summary
      pfam00001
      Location:67 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      12384522..12548433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042242624.2 → XP_042098558.1  lysophosphatidic acid receptor 1 isoform X2

      UniProtKB/TrEMBL
      W5P9Y0
      Conserved Domains (1) summary
      cd15344
      Location:32 → 304
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_012111055.5 → XP_011966445.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011966445.1

      UniProtKB/TrEMBL
      A0A6P3T7Z6, A0A6P7DLP5, W5P9X9, W5P9Y0
      Related
      ENSOARP00020000710.1, ENSOART00020000887.2
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_060408794.1 → XP_060264777.1  lysophosphatidic acid receptor 1 isoform X2

    4. XM_027963887.3 → XP_027819688.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A6P3T7Z6, A0A6P7DLP5, W5P9X9, W5P9Y0
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_012111061.5 → XP_011966451.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011966451.1

      UniProtKB/TrEMBL
      A0A6P3T7Z6, A0A6P7DLP5, W5P9X9, W5P9Y0
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_042242623.2 → XP_042098557.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A6P3T7Z6, A0A6P7DLP5, W5P9X9, W5P9Y0
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_042242622.2 → XP_042098556.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A6P3T7Z6, A0A6P7DLP5, W5P9X9, W5P9Y0
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46628.1 GenPept UniProtKB/Swiss-Prot:P46628

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