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    Prkn parkin RBR E3 ubiquitin protein ligase [ Mus caroli (Ryukyu mouse) ]

    Gene ID: 110312630, updated on 15-Mar-2024

    Summary

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    Gene symbol
    Prkn
    Gene description
    parkin RBR E3 ubiquitin protein ligase
    See related
    Ensembl:MGP_CAROLIEiJ_G0021055
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Mus caroli
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    human mouse all
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    Genomic context

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    See Prkn in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    101 current CAROLI_EIJ_v1.1 (GCF_900094665.1) 17 NC_034586.1 (4885905..6068022, complement)

    Chromosome 17 - NC_034586.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene teratocarcinoma-derived growth factor pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene ATP synthase subunit f, mitochondrial pseudogene Neighboring gene parkin coregulated Neighboring gene uncharacterized LOC110312215

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_034586.1 Chromosome 17 Reference CAROLI_EIJ_v1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase parkin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Mus caroli Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CAROLI_EIJ_v1.1 Primary Assembly

    Genomic

    1. NC_034586.1 Reference CAROLI_EIJ_v1.1 Primary Assembly

      Range
      4885905..6068022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021186390.2 → XP_021042049.1  E3 ubiquitin-protein ligase parkin isoform X2

      UniProtKB/TrEMBL
      A0A6P5R3Z3
      Related
      MGP_CAROLIEiJ_P0042685, MGP_CAROLIEiJ_T0042685.1
      Conserved Domains (5) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:312 → 374
      IBR; In Between Ring fingers
      pfam01485
      Location:412 → 452
      IBR; IBR domain, a half RING-finger domain
      cd16627
      Location:235 → 293
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 138
      UBQ; Ubiquitin homologues

    2. XM_029471043.1 → XP_029326903.1  E3 ubiquitin-protein ligase parkin isoform X3

      UniProtKB/TrEMBL
      A0A6P7QAM3

    3. XM_021186389.2 → XP_021042048.1  E3 ubiquitin-protein ligase parkin isoform X1

      UniProtKB/TrEMBL
      A0A6P5R9T0
      Conserved Domains (5) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:313 → 375
      IBR; In Between Ring fingers
      pfam01485
      Location:413 → 453
      IBR; IBR domain, a half RING-finger domain
      cd16627
      Location:236 → 294
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 144
      UBQ; Ubiquitin homologues

    4. XM_021186391.2 → XP_021042050.1  E3 ubiquitin-protein ligase parkin isoform X4

      UniProtKB/TrEMBL
      A0A6P5RG35
      Related
      MGP_CAROLIEiJ_T0042691.1
      Conserved Domains (4) summary
      TIGR00601
      Location:13 → 144
      rad23; UV excision repair protein Rad23
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17976
      Location:145 → 217
      zf-RING_12; RING/Ubox like zinc-binding domain
      pfam17978
      Location:228 → 245
      zf-RING_14; RING/Ubox like zinc-binding domain
    Nucleotide Protein
    Heading Accession and Version

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