NRXN3 neurexin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NRXN3provided by HGNC
Official Full Name: neurexin 3provided by HGNC
Primary source: HGNC:HGNC:8010
See related: Ensembl:ENSG00000021645 MIM:600567; AllianceGenome:HGNC:8010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C14orf60
Summary: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Expression: Biased expression in brain (RPKM 7.1), adrenal (RPKM 1.0) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q24.3-q31.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (78170373..79868291)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (72379419..74078363)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (78636716..80334634)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.", trans "Nikotin Kullanim Bozuklugunun Neurexin 3 Gen Polimorfizmi ile Iliskisi.
Title: Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.
Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.", trans "Nikotin Kullanim Bozuklugunun Neurexin 3 Gen Polimorfizmi ile Iliskisi.
Title: Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.
Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.
Title: Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.
Modeling a Neurexin-3alpha Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.
Title: Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.
Study found that expression and ratio of transmembrane and soluble NRXN3 isoforms were reduced in Alzheimer disease (AD) postmortem brains and inversely correlated with inflammasome component NLRP3 in AD brain regions.
Title: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.
The neurexins are a family of synaptic adhesion proteins encoded by paralogous genes that play key roles in synaptic function.
Title: Neurexin gene family variants as risk factors for autism spectrum disorder.
NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons.
Title: Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.
The rare variants in NRXN3 were significantly associated with smoking status.
Title: The contribution of rare and common variants in 30 genes to risk nicotine dependence.
This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases
Title: Molecular analysis of cluster headache.
The study showed that markers rs2217887 (NRXN3) showed weak associations.
Title: Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study on obesity and obesity-related traits. EBI GWAS Catalog EBI GWAS CatalogPubMed
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variation and performance on standardized cognitive tests. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NRXN3	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-106288 (e-PCR)
- UniSTS:169728

G35944 (e-PCR)
- UniSTS:36609

SHGC-142566 (e-PCR)
- UniSTS:171527

G35636 (e-PCR)
- UniSTS:37385

D14S95E (e-PCR)
- UniSTS:147467

SHGC-83148 (e-PCR)
- UniSTS:101131

SHGC-58924 (e-PCR)
- UniSTS:94478

G35504 (e-PCR)
- UniSTS:53777

GDB:434012 (e-PCR)
- UniSTS:157204

SHGC-85059 (e-PCR)
- UniSTS:103444

SHGC-60215 (e-PCR)
- UniSTS:167702

G62489 (e-PCR)
- UniSTS:139547

RH119952 (e-PCR)
- UniSTS:133154

D14S868 (e-PCR)
- UniSTS:50978

RH120558 (e-PCR)
- UniSTS:132391

RH120559 (e-PCR)
- UniSTS:132392

RH123563 (e-PCR)
- UniSTS:135983

D1S1190 (e-PCR)
- UniSTS:149296

PMC156606P3 (e-PCR)
- UniSTS:271410

D8S2278 (e-PCR)
- UniSTS:473906

PMC156606P4 (e-PCR)
- UniSTS:271411

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-83446 (e-PCR)
- UniSTS:101939

AFM280va5 (e-PCR)
- UniSTS:56627

WI-13595 (e-PCR)
- UniSTS:11064

G35388 (e-PCR)
- UniSTS:47679

G48206 (e-PCR)
- UniSTS:95303

WI-10441 (e-PCR)
- UniSTS:13128

G17817 (e-PCR)
- UniSTS:25420

G15990 (e-PCR)
- UniSTS:37710

AL034006 (e-PCR)
- UniSTS:93520

L18426 (e-PCR)
- UniSTS:34648

G36313 (e-PCR)
- UniSTS:82521

SHGC-85186 (e-PCR)
- UniSTS:104031

G36001 (e-PCR)
- UniSTS:74339

SHGC-79243 (e-PCR)
- UniSTS:102774

RH78382 (e-PCR)
- UniSTS:66946

D16S3027 (e-PCR), detects polymorphism
- UniSTS:18060

D14S243 (e-PCR)
- UniSTS:148365

D14S287 (e-PCR)
- UniSTS:32657

AFM267YG9 (e-PCR)
- UniSTS:81814

D14S862 (e-PCR)
- UniSTS:28576

SHGC-82549 (e-PCR)
- UniSTS:95650

D14S287 (e-PCR)
- UniSTS:50604

SHGC-85230 (e-PCR)
- UniSTS:104366

G36312 (e-PCR)
- UniSTS:9650

SHGC-144860 (e-PCR)
- UniSTS:172466

G43263 (e-PCR)
- UniSTS:94908

RH122097 (e-PCR)
- UniSTS:134848

SGC31195 (e-PCR)
- UniSTS:19912

WI-22695 (e-PCR)
- UniSTS:32976

RH123687 (e-PCR)
- UniSTS:135892

SHGC-79776 (e-PCR)
- UniSTS:101091

SHGC-144872 (e-PCR)
- UniSTS:174308

D14S110E (e-PCR)
- UniSTS:148200

RH118934 (e-PCR)
- UniSTS:138220

D11S3316 (e-PCR)
- UniSTS:152558

STS-AA021057 (e-PCR)
- UniSTS:50929

D14S762 (e-PCR)
- UniSTS:1269

D14S1323 (e-PCR)
- UniSTS:65269

RH70976 (e-PCR)
- UniSTS:44538

SHGC-104647 (e-PCR)
- UniSTS:168958

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info
enables transmembrane signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adult behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	TAS Traceable Author Statement more info
involved_in learning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in social behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vocalization behavior	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of trans-synaptic protein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neurexin 3

Names: neurexin III; neurexin-3-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052991.1 RefSeqGene

Range

5001..1702919

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001105250.3 → NP_001098720.1 neurexin 3 isoform 3 precursor

See identical proteins and their annotated locations for NP_001098720.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.

Source sequence(s)

AF123462, BC150194, DA243312

Consensus CDS

CCDS45145.1

UniProtKB/Swiss-Prot

Q9HDB5

Related

ENSP00000394426.2, ENST00000428277.6

Conserved Domains (2) summary

cd00110
Location:86 → 265

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:385 → 420

Syndecan; Syndecan domain
NM_001272020.2 → NP_001258949.1 neurexin 3 isoform 4 precursor

See identical proteins and their annotated locations for NP_001258949.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.

Source sequence(s)

AF123462, AK056530, BC150194

Consensus CDS

CCDS61515.1

UniProtKB/Swiss-Prot

A5PKW8, A8MPU5, B3KPM7, Q6NUR0, Q8IUD8, Q9HDB5

UniProtKB/TrEMBL

A0A7I2V2B1

Related

ENSP00000451672.1, ENST00000557594.5

Conserved Domains (2) summary

cd00110
Location:86 → 235

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:563 → 598

Syndecan; Syndecan domain
NM_001330195.2 → NP_001317124.1 neurexin 3 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (7)

Source sequence(s)

AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

Consensus CDS

CCDS81831.1

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

UniProtKB/TrEMBL

A0A0A0MR89

Related

ENSP00000338349.7, ENST00000335750.7

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1497 → 1532

Syndecan; Syndecan domain

pfam02210
Location:899 → 1027

Laminin_G_2; Laminin G domain
NM_001366425.1 → NP_001353354.1 neurexin 3 isoform 6

Status: REVIEWED

Source sequence(s)

AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1467 → 1502

Syndecan; Syndecan domain

pfam02210
Location:899 → 1027

Laminin_G_2; Laminin G domain
NM_001366426.1 → NP_001353355.1 neurexin 3 isoform 7

Status: REVIEWED

Source sequence(s)

AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

Consensus CDS

CCDS91913.1

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

UniProtKB/TrEMBL

A0A0U1RQC5

Related

ENSP00000488920.2, ENST00000634499.2

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1394 → 1429

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
NM_004796.6 → NP_004787.2 neurexin 3 isoform 1

See identical proteins and their annotated locations for NP_004787.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC007056, AC026888, AF123462, BC150194, BC152457, DA213090

Consensus CDS

CCDS9870.1

UniProtKB/Swiss-Prot

Q9HDB5, Q9Y4C0

Related

ENSP00000451648.1, ENST00000554719.5

Conserved Domains (5) summary

smart00282
Location:97 → 246

LamG; Laminin G domain

cd00054
Location:274 → 307

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:718 → 867

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:987 → 1022

Syndecan; Syndecan domain

pfam02210
Location:526 → 654

Laminin_G_2; Laminin G domain
NM_138970.5 → NP_620426.2 neurexin 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_620426.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.

Source sequence(s)

AF123462, AK056530, BC059368, BC150194

Consensus CDS

CCDS9871.1

UniProtKB/Swiss-Prot

Q9HDB5

Related

ENSP00000281127.7, ENST00000281127.11

Conserved Domains (2) summary

cd00110
Location:86 → 235

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:358 → 393

Syndecan; Syndecan domain

RNA

NR_073546.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains multiple differences in its 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF123462, AJ493127, AK056530, BC150194
NR_073547.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) contains multiple differences in its 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF123462, AJ316284, BC150194, DA083962
NR_158973.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
NR_158974.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
NR_158975.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

78170373..79868291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537363.2 → XP_011535665.1 neurexin 3 isoform X1

See identical proteins and their annotated locations for XP_011535665.1

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 425

LamG; Laminin G domain

cd00054
Location:659 → 692

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1613 → 1648

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_011537368.2 → XP_011535670.1 neurexin 3 isoform X15

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 425

LamG; Laminin G domain

cd00054
Location:659 → 692

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1512 → 1547

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_011537371.2 → XP_011535673.1 neurexin 3 isoform X27

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 425

LamG; Laminin G domain

cd00054
Location:659 → 692

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1405 → 1440

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_005268218.4 → XP_005268275.1 neurexin 3 isoform X2

See identical proteins and their annotated locations for XP_005268275.1

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 425

LamG; Laminin G domain

cd00054
Location:659 → 692

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1610 → 1645

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_011537369.2 → XP_011535671.1 neurexin 3 isoform X16

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 425

LamG; Laminin G domain

cd00054
Location:659 → 692

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1509 → 1544

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_011537372.2 → XP_011535674.1 neurexin 3 isoform X28

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 425

LamG; Laminin G domain

cd00054
Location:659 → 692

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1402 → 1437

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_017021799.3 → XP_016877288.1 neurexin 3 isoform X10

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_017021800.2 → XP_016877289.1 neurexin 3 isoform X23

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_011537366.2 → XP_011535668.1 neurexin 3 isoform X4

See identical proteins and their annotated locations for XP_011535668.1

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1605 → 1640

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_047431946.1 → XP_047287902.1 neurexin 3 isoform X18

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431953.1 → XP_047287909.1 neurexin 3 isoform X29

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431939.1 → XP_047287895.1 neurexin 3 isoform X5

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_011537370.2 → XP_011535672.1 neurexin 3 isoform X19

See identical proteins and their annotated locations for XP_011535672.1

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:286 → 417

LamG; Laminin G domain

cd00054
Location:651 → 684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1501 → 1536

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_006720322.3 → XP_006720385.1 neurexin 3 isoform X3

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:282 → 421

LamG; Laminin G domain

cd00054
Location:655 → 688

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1609 → 1644

Syndecan; Syndecan domain

pfam02210
Location:907 → 1035

Laminin_G_2; Laminin G domain
XM_047431945.1 → XP_047287901.1 neurexin 3 isoform X17

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_024449752.2 → XP_024305520.1 neurexin 3 isoform X42

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:282 → 421

LamG; Laminin G domain

cd00054
Location:655 → 688

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1398 → 1433

Syndecan; Syndecan domain

pfam02210
Location:907 → 1035

Laminin_G_2; Laminin G domain
XM_047431950.1 → XP_047287906.1 neurexin 3 isoform X24

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431957.1 → XP_047287913.1 neurexin 3 isoform X34

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431951.1 → XP_047287907.1 neurexin 3 isoform X25

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_017021794.2 → XP_016877283.1 neurexin 3 isoform X6

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431947.1 → XP_047287903.1 neurexin 3 isoform X20

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431954.1 → XP_047287910.1 neurexin 3 isoform X30

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431940.1 → XP_047287896.1 neurexin 3 isoform X7

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_017021805.2 → XP_016877294.1 neurexin 3 isoform X31

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431942.1 → XP_047287898.1 neurexin 3 isoform X11

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431952.1 → XP_047287908.1 neurexin 3 isoform X26

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431958.1 → XP_047287914.1 neurexin 3 isoform X35

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431943.1 → XP_047287899.1 neurexin 3 isoform X12

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431959.1 → XP_047287915.1 neurexin 3 isoform X36

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_017021798.2 → XP_016877287.1 neurexin 3 isoform X8

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431948.1 → XP_047287904.1 neurexin 3 isoform X21

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431955.1 → XP_047287911.1 neurexin 3 isoform X32

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431941.1 → XP_047287897.1 neurexin 3 isoform X9

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431949.1 → XP_047287905.1 neurexin 3 isoform X22

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431956.1 → XP_047287912.1 neurexin 3 isoform X33

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_024449751.2 → XP_024305519.1 neurexin 3 isoform X13

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1562 → 1597

Syndecan; Syndecan domain

pfam02210
Location:890 → 1018

Laminin_G_2; Laminin G domain
XM_047431944.1 → XP_047287900.1 neurexin 3 isoform X14

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_024449753.2 → XP_024305521.1 neurexin 3 isoform X37

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Conserved Domains (6) summary

smart00282
Location:282 → 413

LamG; Laminin G domain

cd00054
Location:647 → 680

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:35 → 181

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:202 → 232

EGF; EGF-like domain

pfam01034
Location:1351 → 1386

Syndecan; Syndecan domain

pfam02210
Location:890 → 1018

Laminin_G_2; Laminin G domain
XM_047431960.1 → XP_047287916.1 neurexin 3 isoform X38

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431961.1 → XP_047287917.1 neurexin 3 isoform X39

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431964.1 → XP_047287920.1 neurexin 3 isoform X41

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
XM_047431963.1 → XP_047287919.1 neurexin 3 isoform X40

UniProtKB/Swiss-Prot

A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

Related

ENSP00000450683.1, ENST00000554738.5