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    ZNF32 zinc finger protein 32 [ Homo sapiens (human) ]

    Gene ID: 7580, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF32provided by HGNC
    Official Full Name
    zinc finger protein 32provided by HGNC
    Primary source
    HGNC:HGNC:13095
    See related
    Ensembl:ENSG00000169740 MIM:194539; AllianceGenome:HGNC:13095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX30; ZNF637; Zfp637
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 6.7), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF32 in Genome Data Viewer
    Location:
    10q11.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (43643862..43648881, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (44524781..44529800, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (44139310..44144329, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2335 Neighboring gene zinc finger protein 485 Neighboring gene uncharacterized LOC124902416 Neighboring gene ZNF32 antisense RNA 3 Neighboring gene ribosomal protein L21 pseudogene 88 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:44141084-44142283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2336 Neighboring gene ZNF32 antisense RNA 1 Neighboring gene ZNF32 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:44162766-44162945 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2337 Neighboring gene uncharacterized LOC124902417 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12372 Neighboring gene SPRING1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 32
    Names
    C2H2-546
    zinc finger protein 32 (KOX 30)
    zinc finger protein KOX30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005368.3NP_001005368.1  zinc finger protein 32 isoform a

      See identical proteins and their annotated locations for NP_001005368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC022842, HY045180
      Consensus CDS
      CCDS7206.1
      UniProtKB/Swiss-Prot
      P17041, Q92951
      Related
      ENSP00000379143.1, ENST00000395797.1
      Conserved Domains (2) summary
      COG5048
      Location:47237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:7999
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001324164.2NP_001311093.1  zinc finger protein 32 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) and variant 4 both encode the same isoform (b).
      Source sequence(s)
      AL645634
      Conserved Domains (2) summary
      COG5048
      Location:51241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:83103
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001324165.2NP_001311094.1  zinc finger protein 32 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) and variant 3 both encode the same isoform (b).
      Source sequence(s)
      BC022842, HY045180, HY148951
      UniProtKB/Swiss-Prot
      P17041
      Conserved Domains (2) summary
      COG5048
      Location:51241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:83103
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001324166.2NP_001311095.1  zinc finger protein 32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform c.
      Source sequence(s)
      AL645634
      Conserved Domains (2) summary
      COG5048
      Location:22212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:5474
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001324167.2NP_001311096.1  zinc finger protein 32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform c.
      Source sequence(s)
      AL645634
      Conserved Domains (2) summary
      COG5048
      Location:22212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:5474
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001324168.2NP_001311097.1  zinc finger protein 32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform c.
      Source sequence(s)
      BC022842, HY045180
      UniProtKB/Swiss-Prot
      P17041
      Conserved Domains (2) summary
      COG5048
      Location:22212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:5474
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_006973.3NP_008904.1  zinc finger protein 32 isoform a

      See identical proteins and their annotated locations for NP_008904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring variant. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL645634, BC022842, BG477527
      Consensus CDS
      CCDS7206.1
      UniProtKB/Swiss-Prot
      P17041, Q92951
      Related
      ENSP00000363556.2, ENST00000374433.7
      Conserved Domains (2) summary
      COG5048
      Location:47237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:7999
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      43643862..43648881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      44524781..44529800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)