Fgl2 fibrinogen-like protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgl2provided by MGI
Official Full Name: fibrinogen-like protein 2provided by MGI
Primary source: MGI:MGI:103266
See related: Ensembl:ENSMUSG00000039899 AllianceGenome:MGI:103266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: musfiblp
Summary: Acts upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including endometrium epithelium; extraembryonic component; nervous system; placenta; and skeleton. Used to study autoimmune glomerulonephritis. Orthologous to human FGL2 (fibrinogen like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 35.5), ovary adult (RPKM 23.3) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 9.83 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (21577671..21583384)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (21372673..21378386)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD8[+] T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcgammaRIIB.
Title: CD8(+) T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB.
FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models.
Title: FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models.
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells.
Title: Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells.
Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury.
Title: Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury.
FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-kappaB mediated endothelial oxidative stress.
Title: FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-κB mediated endothelial oxidative stress.
Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors.
Title: Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors.
The distinctive role of membrane fibrinogen-like protein 2 in the liver stage of rodent malaria infections.
Title: The distinctive role of membrane fibrinogen-like protein 2 in the liver stage of rodent malaria infections.
Fibrinogen-like protein 2 contributes to normal murine cardiomyocyte maturation and heart development.
Title: Fibrinogen-like protein 2 contributes to normal murine cardiomyocyte maturation and heart development.
Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation.
Title: Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation.
Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice.
Title: Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (2) 1 citation

General gene information

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Markers

Fgl2 (e-PCR), detects polymorphism
- UniSTS:143107

M16238 (e-PCR)
- UniSTS:186266

AI385601 (e-PCR)
- UniSTS:179138

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of dendritic cell antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of memory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroleukin

Names: associated with MHV-3 induced prothrombinase activity; cytotoxic T-lymphocyte-specific protein; prothrombinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.