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    STK33 serine/threonine kinase 33 [ Homo sapiens (human) ]

    Gene ID: 65975, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STK33provided by HGNC
    Official Full Name
    serine/threonine kinase 33provided by HGNC
    Primary source
    HGNC:HGNC:14568
    See related
    Ensembl:ENSG00000130413 MIM:607670; AllianceGenome:HGNC:14568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPGF93
    Summary
    Enables protein serine/threonine kinase activity. Involved in spermatogenesis. Predicted to be located in manchette. Predicted to be active in cytoplasm and nucleus. Implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK33 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8334824..8594228, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8415997..8675974, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8413417..8615775, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8214713-8215283 Neighboring gene VISTA enhancer hs1859 Neighboring gene RIC3 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8244025-8244526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8248695-8249355 Neighboring gene uncharacterized LOC105376536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8271693-8272438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8272439-8273182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8281879-8282380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8283311-8283850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8288990-8289574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8289575-8290158 Neighboring gene MPRA-validated peak1191 silencer Neighboring gene LIM domain only 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8303849-8304410 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:8304411-8304972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8339910-8340410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8347375-8347960 Neighboring gene Sharpr-MPRA regulatory region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8358075-8358892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8359711-8360526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8360626-8361287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8373273-8373772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4385 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3114 Neighboring gene NANOG hESC enhancer GRCh37_chr11:8625413-8625914 Neighboring gene tripartite motif containing 66 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:8692389-8692996 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:8703769-8704968 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene ribosomal protein L27a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella. Ma H, et al. Hum Mol Genet, 2021 Oct 13. PMID 34155512
    2. The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. Rask-Andersen M, et al. PLoS One, 2013. PMID 23967198, Free PMC Article
    3. STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis. Huang L, et al. BMC Cancer, 2015 Jan 21. PMID 25603720, Free PMC Article
    4. STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential. Wang P, et al. Acta Biochim Biophys Sin (Shanghai), 2015 Mar. PMID 25662617
    5. STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium. Chen C, et al. Cancer Biol Ther, 2016 Sep. PMID 27414193, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway.
      Title: Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway.
    2. Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella.
      Title: Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella.
    3. Data show that serine/threonine kinase 33 (STK33) can bind with extracellular signal-regulated kinase 2 (ERK2) and take part in the regulation of ERKs signaling pathway.
      Title: STK33/ERK2 signal pathway contribute the tumorigenesis of colorectal cancer HCT15 cells.
    4. STK33 has pro-tumor function and is a critical downstream mediator of KLF4 in gastric cancer. STK33 may serve as a potential prognostic marker and therapeutic target for gastric cancer.
      Title: Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
    5. inhibition of STK33 in small cell lung carcinoma cells suppressed the cell proliferation and invasion while induced cell apoptosis
      Title: Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
    6. Dysregulated HIF1alpha/STK33 signaling promotes pancreatic ductal adenocarcinoma (PDAC) growth and progression, this suggests that STK33 is a candidate therapeutic target to improve PDAC treatment.
      Title: STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α.
    7. STK33 is a potential oncogene and plays an important role in tumorigenesis of HSCC via regulation of numerous genes.
      Title: STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
    8. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity.
      Title: STK33 promotes hepatocellular carcinoma through binding to c-Myc.
    9. Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC.
      Title: STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
    10. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition.
      Title: STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manchette assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in manchette ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 33
    NP_001275987.1
    NP_001275988.1
    NP_001275990.1
    NP_001339316.1
    NP_001339317.1
    NP_001339318.1
    NP_001339319.1
    NP_001339320.1
    NP_001339321.1
    NP_001339322.1
    NP_001339323.1
    NP_001339324.1
    NP_001339325.1
    NP_001339326.1
    NP_001339327.1
    NP_001339328.1
    NP_112168.1
    XP_011518592.1
    XP_011518599.1
    XP_016873633.1
    XP_016873634.1
    XP_016873635.1
    XP_016873643.1
    XP_016873644.1
    XP_016873646.1
    XP_047283403.1
    XP_047283404.1
    XP_047283405.1
    XP_047283406.1
    XP_047283407.1
    XP_047283408.1
    XP_047283409.1
    XP_047283410.1
    XP_047283411.1
    XP_047283412.1
    XP_047283413.1
    XP_047283414.1
    XP_047283415.1
    XP_047283416.1
    XP_047283417.1
    XP_047283418.1
    XP_047283419.1
    XP_047283420.1
    XP_047283421.1
    XP_047283422.1
    XP_047283423.1
    XP_047283424.1
    XP_047283425.1
    XP_047283426.1
    XP_047283427.1
    XP_047283428.1
    XP_047283429.1
    XP_047283430.1
    XP_047283431.1
    XP_047283432.1
    XP_054225658.1
    XP_054225659.1
    XP_054225660.1
    XP_054225661.1
    XP_054225662.1
    XP_054225663.1
    XP_054225664.1
    XP_054225665.1
    XP_054225666.1
    XP_054225667.1
    XP_054225668.1
    XP_054225669.1
    XP_054225670.1
    XP_054225671.1
    XP_054225672.1
    XP_054225673.1
    XP_054225674.1
    XP_054225675.1
    XP_054225676.1
    XP_054225677.1
    XP_054225678.1
    XP_054225679.1
    XP_054225680.1
    XP_054225681.1
    XP_054225682.1
    XP_054225683.1
    XP_054225684.1
    XP_054225685.1
    XP_054225686.1
    XP_054225687.1
    XP_054225688.1
    XP_054225689.1
    XP_054225690.1
    XP_054225691.1
    XP_054225692.1
    XP_054225693.1
    XP_054225694.1
    XP_054225695.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289058.2 → NP_001275987.1  serine/threonine-protein kinase 33 isoform b

      See identical proteins and their annotated locations for NP_001275987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region, and uses a downstream translation initiation codon, compared to variant 1. This results in a protein (isoform b) with a shorter C-terminus, compared to isoform a. Variants 2, 12, and 13 all encode the same isoform (b).
      Source sequence(s)
      AJ303380, AK293193, BU580591, DA348768
      Consensus CDS
      CCDS73254.1
      UniProtKB/TrEMBL
      B4DDH2
      Related
      ENSP00000436418.1, ENST00000534493.5
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    2. NM_001289059.2 → NP_001275988.1  serine/threonine-protein kinase 33 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the coding region, and uses a downstream translation initiation codon, compared to variant 1. This results in a protein (isoform c) with a shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AC105357, AJ303380, AK092720, BU580591, DA348768
      Consensus CDS
      CCDS73253.1
      UniProtKB/TrEMBL
      B3KS39, F8WAK5
      Related
      ENSP00000351743.3, ENST00000358872.7
      Conserved Domains (2) summary
      smart00220
      Location:1 → 194
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 194
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001289061.2 → NP_001275990.1  serine/threonine-protein kinase 33 isoform a

      See identical proteins and their annotated locations for NP_001275990.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4-11 all encode the same isoform (a).
      Source sequence(s)
      AJ303380, AK093251, BC031231, BU580591, DB049619
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Related
      ENSP00000379905.1, ENST00000396672.5
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    4. NM_001352387.2 → NP_001339316.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, and 6-11, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    5. NM_001352388.2 → NP_001339317.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7-11, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    6. NM_001352389.2 → NP_001339318.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8-11, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Related
      ENSP00000509322.1, ENST00000687296.1
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    7. NM_001352390.2 → NP_001339319.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 4-7, and 9-11, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    8. NM_001352391.2 → NP_001339320.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 4-8, 10, and 11, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    9. NM_001352392.2 → NP_001339321.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 4-9, and 11, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    10. NM_001352393.2 → NP_001339322.1  serine/threonine-protein kinase 33 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 1 and 4-10, encodes isoform a.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    11. NM_001352394.2 → NP_001339323.1  serine/threonine-protein kinase 33 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 2 and 13, encodes isoform b.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS73254.1
      UniProtKB/TrEMBL
      B4DDH2
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    12. NM_001352395.2 → NP_001339324.1  serine/threonine-protein kinase 33 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 2 and 12, encodes isoform b.
      Source sequence(s)
      AC104360, AC105357
      Consensus CDS
      CCDS73254.1
      UniProtKB/TrEMBL
      B4DDH2
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    13. NM_001352396.2 → NP_001339325.1  serine/threonine-protein kinase 33 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform d.
      Source sequence(s)
      AC104360, AC105357
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    14. NM_001352397.2 → NP_001339326.1  serine/threonine-protein kinase 33 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform d.
      Source sequence(s)
      AC104360, AC105357
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    15. NM_001352398.2 → NP_001339327.1  serine/threonine-protein kinase 33 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform d.
      Source sequence(s)
      AC104360, AC105357
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    16. NM_001352399.2 → NP_001339328.1  serine/threonine-protein kinase 33 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC104360, AC105357
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    17. NM_030906.4 → NP_112168.1  serine/threonine-protein kinase 33 isoform a

      See identical proteins and their annotated locations for NP_112168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4-11 all encode the same isoform (a).
      Source sequence(s)
      AJ303380, AK093251, BC031231, BU580591, DB049619
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Related
      ENSP00000320754.1, ENST00000315204.5
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      8334824..8594228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427469.1 → XP_047283425.1  serine/threonine-protein kinase 33 isoform X3

    2. XM_047427463.1 → XP_047283419.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    3. XM_017018157.2 → XP_016873646.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    4. XM_047427473.1 → XP_047283429.1  serine/threonine-protein kinase 33 isoform X4

    5. XM_047427474.1 → XP_047283430.1  serine/threonine-protein kinase 33 isoform X4

    6. XM_047427459.1 → XP_047283415.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    7. XM_047427458.1 → XP_047283414.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    8. XM_047427476.1 → XP_047283432.1  serine/threonine-protein kinase 33 isoform X5

    9. XM_047427465.1 → XP_047283421.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    10. XM_047427472.1 → XP_047283428.1  serine/threonine-protein kinase 33 isoform X4

    11. XM_047427448.1 → XP_047283404.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    12. XM_047427451.1 → XP_047283407.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    13. XM_047427468.1 → XP_047283424.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    14. XM_047427467.1 → XP_047283423.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    15. XM_047427449.1 → XP_047283405.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    16. XM_047427475.1 → XP_047283431.1  serine/threonine-protein kinase 33 isoform X4

    17. XM_017018144.3 → XP_016873633.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    18. XM_047427460.1 → XP_047283416.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    19. XM_047427452.1 → XP_047283408.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    20. XM_047427464.1 → XP_047283420.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    21. XM_047427470.1 → XP_047283426.1  serine/threonine-protein kinase 33 isoform X4

    22. XM_047427450.1 → XP_047283406.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    23. XM_011520297.3 → XP_011518599.1  serine/threonine-protein kinase 33 isoform X2

      See identical proteins and their annotated locations for XP_011518599.1

      UniProtKB/TrEMBL
      B4DDH2
      Conserved Domains (1) summary
      cd14097
      Location:73 → 340
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    24. XM_047427466.1 → XP_047283422.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    25. XM_047427462.1 → XP_047283418.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    26. XM_047427454.1 → XP_047283410.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    27. XM_047427456.1 → XP_047283412.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    28. XM_047427457.1 → XP_047283413.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    29. XM_011520290.3 → XP_011518592.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_011518592.1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    30. XM_047427455.1 → XP_047283411.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    31. XM_047427447.1 → XP_047283403.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    32. XM_047427453.1 → XP_047283409.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    33. XM_017018146.2 → XP_016873635.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    34. XM_017018145.2 → XP_016873634.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    35. XM_017018154.2 → XP_016873643.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Related
      ENSP00000416750.1, ENST00000447869.5
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    36. XM_047427461.1 → XP_047283417.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    37. XM_047427471.1 → XP_047283427.1  serine/threonine-protein kinase 33 isoform X4

    38. XM_017018155.3 → XP_016873644.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3
      Conserved Domains (1) summary
      cd14097
      Location:114 → 381
      STKc_STK33; Catalytic domain of Serine/Threonine Kinase 33

    RNA

    1. XR_007062494.1 RNA Sequence

    2. XR_001747939.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      8415997..8675974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369714.1 → XP_054225689.1  serine/threonine-protein kinase 33 isoform X3

    2. XM_054369706.1 → XP_054225681.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    3. XM_054369708.1 → XP_054225683.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    4. XM_054369717.1 → XP_054225692.1  serine/threonine-protein kinase 33 isoform X4

    5. XM_054369718.1 → XP_054225693.1  serine/threonine-protein kinase 33 isoform X4

    6. XM_054369698.1 → XP_054225673.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    7. XM_054369696.1 → XP_054225671.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    8. XM_054369720.1 → XP_054225695.1  serine/threonine-protein kinase 33 isoform X5

    9. XM_054369709.1 → XP_054225684.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    10. XM_054369716.1 → XP_054225691.1  serine/threonine-protein kinase 33 isoform X4

    11. XM_054369686.1 → XP_054225661.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    12. XM_054369690.1 → XP_054225665.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    13. XM_054369713.1 → XP_054225688.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    14. XM_054369712.1 → XP_054225687.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    15. XM_054369687.1 → XP_054225662.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    16. XM_054369719.1 → XP_054225694.1  serine/threonine-protein kinase 33 isoform X4

    17. XM_054369697.1 → XP_054225672.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    18. XM_054369700.1 → XP_054225675.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    19. XM_054369689.1 → XP_054225664.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    20. XM_054369707.1 → XP_054225682.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    21. XM_054369715.1 → XP_054225690.1  serine/threonine-protein kinase 33 isoform X4

    22. XM_054369688.1 → XP_054225663.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    23. XM_054369711.1 → XP_054225686.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    24. XM_054369710.1 → XP_054225685.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      B4DDH2

    25. XM_054369702.1 → XP_054225677.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    26. XM_054369692.1 → XP_054225667.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    27. XM_054369694.1 → XP_054225669.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    28. XM_054369695.1 → XP_054225670.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    29. XM_054369699.1 → XP_054225674.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    30. XM_054369693.1 → XP_054225668.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    31. XM_054369684.1 → XP_054225659.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    32. XM_054369691.1 → XP_054225666.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    33. XM_054369683.1 → XP_054225658.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    34. XM_054369685.1 → XP_054225660.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    35. XM_054369703.1 → XP_054225678.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    36. XM_054369705.1 → XP_054225680.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    37. XM_054369701.1 → XP_054225676.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    38. XM_054369704.1 → XP_054225679.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q658S6, Q8NEF5, Q9BYT3

    RNA

    1. XR_008488425.1 RNA Sequence

    2. XR_008488426.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYT3.1 GenPept UniProtKB/Swiss-Prot:Q9BYT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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