Pif1 PIF1 5'-to-3' DNA helicase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pif1provided by RGD
Full Name: PIF1 5'-to-3' DNA helicaseprovided by RGD
Primary source: RGD:1586053
See related: EnsemblRapid:ENSRNOG00000015878 AllianceGenome:RGD:1586053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; helicase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including DNA duplex unwinding; negative regulation of telomere maintenance via telomerase; and protein-DNA-RNA complex disassembly. Predicted to be located in chromosome, telomeric region. Predicted to be active in replication fork. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 25.8), Thymus (RPKM 18.6) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (75005820..75015331)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (66110641..66120202)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (71124477..71133460)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-3' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables 5'-3' DNA/RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables G-quadruplex DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables telomerase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein-DNA-RNA complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ATP-dependent DNA helicase PIF1

Names: DNA repair and recombination helicase PIF1; PIF1/RRM3 DNA helicase-like protein; Pif1/Rrm3 DNA-helicase-like protein

NP_001037718.1

EC 3.6.4.12

XP_038937819.1

EC 3.6.4.12

XP_038937820.1

EC 3.6.4.12

XP_063122010.1

EC 3.6.4.12

XP_063122011.1

EC 3.6.4.12

XP_063122012.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044253.1 → NP_001037718.1 ATP-dependent DNA helicase PIF1

See identical proteins and their annotated locations for NP_001037718.1

Status: PROVISIONAL

Source sequence(s)

DQ489562

UniProtKB/Swiss-Prot

Q1HG60

Conserved Domains (2) summary

pfam02689
Location:547 → 594

Herpes_Helicase; Helicase

cl21455
Location:202 → 500

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

75005820..75015331

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081892.2 → XP_038937820.1 ATP-dependent DNA helicase PIF1 isoform X4

Conserved Domains (1) summary

cd18037
Location:206 → 377

DEXSc_Pif1_like; DEAD-box helicase domain of Pif1
XM_039081891.2 → XP_038937819.1 ATP-dependent DNA helicase PIF1 isoform X3

Conserved Domains (1) summary

cd18037
Location:206 → 377

DEXSc_Pif1_like; DEAD-box helicase domain of Pif1
XM_063265941.1 → XP_063122011.1 ATP-dependent DNA helicase PIF1 isoform X1
XM_063265940.1 → XP_063122010.1 ATP-dependent DNA helicase PIF1 isoform X1
XM_063265942.1 → XP_063122012.1 ATP-dependent DNA helicase PIF1 isoform X2

UniProtKB/Swiss-Prot

Q1HG60

Related

ENSRNOP00000021265.6, ENSRNOT00000021265.7