hes7 hairy and enhancer of split 7, gene 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: hes7provided by Xenbase
Official Full Name: hairy and enhancer of split 7, gene 1provided by Xenbase
Primary source: Xenbase:XB-GENE-876465
See related: Ensembl:ENSXETG00000009079 AllianceGenome:Xenbase:XB-GENE-876465
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: XHR1; hes7.1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within midbrain-hindbrain boundary development and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (144639169..144641758)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (131475348..131477936, complement)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within midbrain-hindbrain boundary development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcription factor HES-7.1

Names: HES-related 1; hairy and enhancer of split 7.1; helix-loop-helix DNA-binding domain protein with Hairy Orange domain, similar to hes7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045701.1 → NP_001039166.1 transcription factor HES-7.1

See identical proteins and their annotated locations for NP_001039166.1

Status: PROVISIONAL

Source sequence(s)

CR760960

UniProtKB/Swiss-Prot

Q28HA8

UniProtKB/TrEMBL

A0A5S6LDM2

Related

ENSXETP00000066573.2, ENSXETT00000090188.2

Conserved Domains (2) summary

pfam07527
Location:84 → 121

Hairy_orange; Hairy Orange

cd11462
Location:14 → 74

bHLH-O_HES7; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 7 (HES-7) and similar proteins