IFIH1 interferon induced with helicase C domain 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: IFIH1provided by CGNC
Official Full Name: interferon induced with helicase C domain 1provided by CGNC
Primary source: CGNC:8422
See related: Ensembl:ENSGALG00010020999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MDA5; chMDA5
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (20667661..20694378)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (20584165..20610938)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hnRNPH2 as an Inhibitor of Chicken MDA5-Mediated Type I Interferon Response: Analysis Using Chicken MDA5-Host Interactome.
Title: hnRNPH2 as an Inhibitor of Chicken MDA5-Mediated Type I Interferon Response: Analysis Using Chicken MDA5-Host Interactome.
Transcriptomic Analysis of the Chicken MDA5 Response Genes.
Title: Transcriptomic Analysis of the Chicken MDA5 Response Genes.
These data indicate that the MDA5 signaling pathway and innate immune cytokines were induced after avian reovirus infection, which would contribute to the avian reovirus-host interaction, especially at the early infection stage.
Title: Altered gene expression profiles of the MDA5 signaling pathway in peripheral blood lymphocytes of chickens infected with avian reovirus.
role MDA5 in upregulating the transcription of IFN-beta in response to Infectious bronchitis virus infection
Title: Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
Together, these results suggest that miR-34b-5p targets MDA5 to accelerate the proliferation and migration of avian leukosis virus subgroup J-infected cells, and it promotes avian leukosis virus subgroup J replication, via the MDA5 signaling pathway.
Title: MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication.
a approximately 2.5kb chMDA5 gene promoter region was examined and PCR amplified to assess its role in immune response
Title: Promoter structures and differential responses to viral and non-viral inducers of chicken melanoma differentiation-associated gene 5.
LGP2 end-binding may promote nucleation of MDA5 oligomerization on dsRNA.
Title: Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
MDA5 overexpression in HD11 cells resulted in significantly reduced infectious bursal disease virus titers and RNA loads.
Title: Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in cultured macrophages.
The birnavirus VP3 protein inhibits antiviral innate immunity via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5.
Title: Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5.
The results indicated that chicken MDA5 recognized infectious bursal disease virus infection and that this interaction resulted in the activation of chMDA5-related innate immune genes and upregulation of chicken MHC class I.
Title: Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables single-stranded RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to virus	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interferon-induced helicase C domain-containing protein 1

Names: melanoma differentiation-associated protein 5

NP_001180567.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.