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    Rab11fip1 RAB11 family interacting protein 1 (class I) [ Mus musculus (house mouse) ]

    Gene ID: 75767, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rab11fip1provided by MGI
    Official Full Name
    RAB11 family interacting protein 1 (class I)provided by MGI
    Primary source
    MGI:MGI:1923017
    See related
    Ensembl:ENSMUSG00000031488 AllianceGenome:MGI:1923017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rcp; 2010200K21Rik; 4833414G05Rik
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of adiponectin secretion and regulated exocytosis. Predicted to be located in cytosol. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RAB11FIP1 (RAB11 family interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 12.6), colon adult (RPKM 11.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab11fip1 in Genome Data Viewer
    Location:
    8 A2; 8 15.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27628801..27664707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27138773..27174646, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39151 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene VISTA enhancer mm136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:28239113-28239296 Neighboring gene BRF2, RNA polymerase III transcription initiation factor 50kDa subunit Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022 Neighboring gene adrenergic receptor, beta 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage. Rathan-Kumar S, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Sep 1. PMID 35819177, Free PMC Article
    2. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Zhang S, et al. Cell Rep, 2020 Jul 7. PMID 32640214
    3. Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Gundry C, et al. Nat Commun, 2017 Mar 15. PMID 28294115, Free PMC Article
    4. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. Zhang D, et al. CNS Neurosci Ther, 2023 Oct. PMID 37072933, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage.
      Title: Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage.
    2. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion.
      Title: Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC159103

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of adiponectin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 1
    Names
    Rab coupling protein
    rab-coupling protein
    rab11-FIP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080813.2 → NP_001074282.1  rab11 family-interacting protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC119917
      Consensus CDS
      CCDS40311.1
      UniProtKB/TrEMBL
      A0A1B0GRJ0, E9Q8L9
      Related
      ENSMUSP00000058042.7, ENSMUST00000054212.7
      Conserved Domains (2) summary
      cd08682
      Location:20 → 149
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:1109 → 1156
      RBD-FIP; FIP domain

    2. NM_029423.2 → NP_083699.2  rab11 family-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_083699.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC119917, BB619642, BC132094
      Consensus CDS
      CCDS52534.1
      UniProtKB/Swiss-Prot
      Q05A58, Q3UBC2, Q8BN24, Q9D620
      Related
      ENSMUSP00000033878.7, ENSMUST00000033878.14
      Conserved Domains (2) summary
      cd08682
      Location:20 → 149
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:588 → 635
      RBD-FIP; FIP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27628801..27664707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154355.1 → XP_036010248.1  rab11 family-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GRJ0
      Conserved Domains (1) summary
      PHA03247
      Location:339 → 501
      PHA03247; large tegument protein UL36; Provisional

    2. XM_036154353.1 → XP_036010246.1  rab11 family-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GRJ0
      Related
      ENSMUSP00000147543.2, ENSMUST00000209377.2
      Conserved Domains (2) summary
      cd08682
      Location:20 → 149
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      PHA03247
      Location:489 → 651
      PHA03247; large tegument protein UL36; Provisional

    3. XM_036154356.1 → XP_036010249.1  rab11 family-interacting protein 1 isoform X3

      Conserved Domains (1) summary
      cd08682
      Location:20 → 149
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D620.2 GenPept UniProtKB/Swiss-Prot:Q9D620

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