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    Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 242425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gabbr2provided by MGI
    Official Full Name
    gamma-aminobutyric acid type B receptor subunit 2provided by MGI
    Primary source
    MGI:MGI:2386030
    See related
    Ensembl:ENSMUSG00000039809 AllianceGenome:MGI:2386030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gb2; Gm425; Gpr51; GABABR2
    Summary
    Predicted to enable G protein-coupled GABA receptor activity and protein heterodimerization activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; and neuron-glial cell signaling. Located in cytoplasm and neuron projection. Is expressed in brain; eye; and liver. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 32.0), cerebellum adult (RPKM 28.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gabbr2 in Genome Data Viewer
    Location:
    4 B1; 4 25.18 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46662318..46991714, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46662318..46991714, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31850 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 42281 Neighboring gene STARR-seq mESC enhancer starr_10135 Neighboring gene predicted gene, 32208 Neighboring gene predicted gene, 32135 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47002653-47002836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47023500-47023609 Neighboring gene STARR-seq mESC enhancer starr_10138 Neighboring gene STARR-positive B cell enhancer mm9_chr4:47033511-47033812 Neighboring gene predicted gene 568 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice. Heskin-Sweezie R, et al. Neuroscience, 2010 Aug 11. PMID 20394801, Free PMC Article
    2. The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Thuault SJ, et al. Biochem Pharmacol, 2004 Oct 15. PMID 15451409
    3. Compartmentation of GABA B receptor2 expression in the mouse cerebellar cortex. Chung SH, et al. Cerebellum, 2008. PMID 18418671
    4. Presynaptic GABA(B) receptors modulate synaptic facilitation and depression at distinct synapses in fusiform cells of mouse dorsal cochlear nucleus. Irie T, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18190780
    5. Postnatal development of GABAB-receptor-mediated modulation of potassium currents in brainstem respiratory network of mouse. Pfeiffer A, et al. Respir Physiol Neurobiol, 2007 Aug 15. PMID 17428748

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-330 Directs Downregulation of the GABABR2 in the Pathogenesis of Pancreatic Cancer Pain.
      Title: MicroRNA-330 Directs Downregulation of the GABA(B)R2 in the Pathogenesis of Pancreatic Cancer Pain.
    2. Reelin signaling modulates GABAB receptor function in the neocortex.
      Title: Reelin signaling modulates GABA(B) receptor function in the neocortex.
    3. GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
      Title: GABAergic input through GABA(B) receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
    4. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC
      Title: Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression.
    5. GABABR2 has a role as a regulator of glutamine synthetase stability
      Title: Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by γ-aminobutyric type B receptors.
    6. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
      Title: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.
    7. Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum.
      Title: A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum.
    8. Gabbr1 and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers
      Title: A transcriptional study in mice with different ethanol-drinking profiles: possible involvement of the GABA(B) receptor.
    9. GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 expression toward disturbance of osteoclastogenesis after down-regulation of RANKL expression in mouse bone.
      Title: Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone.
    10. results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 protein levels in mouse brains during postnatal development in vivo
      Title: Gradual downregulation of protein expression of the partner GABA(B)R2 subunit during postnatal brain development in mice defective of GABA(B)R1 subunit.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to G protein-coupled GABA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled GABA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron-glial cell signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic transmission, GABAergic NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled GABA receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of G protein-coupled receptor heterodimeric complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of G protein-coupled receptor heterodimeric complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of GABA receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid type B receptor subunit 2
    Names
    gamma-aminobutyric acid (GABA) B receptor, 2
    ortholog of human G protein-coupled receptor 51 GPR51

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081141.2 → NP_001074610.1  gamma-aminobutyric acid type B receptor subunit 2 precursor

      See identical proteins and their annotated locations for NP_001074610.1

      Status: VALIDATED

      Source sequence(s)
      AL772399, AL831741, AL844224, BX005247, BX571848
      Consensus CDS
      CCDS38758.1
      UniProtKB/Swiss-Prot
      A2AL05, Q80T41
      Related
      ENSMUSP00000103378.3, ENSMUST00000107749.4
      Conserved Domains (4) summary
      PRK03992
      Location:785 → 863
      PRK03992; proteasome-activating nucleotidase; Provisional
      cd15294
      Location:479 → 748
      7tmC_GABA-B-R2; gamma-aminobutyric acid type B receptor subunit 2, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam18455
      Location:778 → 816
      GBR2_CC; Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain
      cd06366
      Location:57 → 459
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      46662318..46991714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T41.2 GenPept UniProtKB/Swiss-Prot:Q80T41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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