Slc22a2 solute carrier family 22 (organic cation transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a2provided by MGI
Official Full Name: solute carrier family 22 (organic cation transporter), member 2provided by MGI
Primary source: MGI:MGI:1335072
See related: Ensembl:ENSMUSG00000040966 AllianceGenome:MGI:1335072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oct2; Orct2; mOCT2
Summary: Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in cellular detoxification and xenobiotic transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane. Is expressed in several structures, including metanephros; nasal cavity mucosa; nervous system; placenta; and ureter. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 64.5), liver adult (RPKM 7.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 8.61 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (12803076..12847376)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12584189..12628489)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain.
Title: Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain.
Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin.
Title: Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin.
Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Title: Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Title: Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes
Title: Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling.
we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2
Title: Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.
Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.
Title: Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.
Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.
Title: Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2.
Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours.
Title: Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.
Title: Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:463369

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:144419

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:144420

AJ006036 (e-PCR)
- UniSTS:160617

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:545990

Slc22a2 (e-PCR), detects polymorphism
- UniSTS:233959

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrimidine nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyrimidine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables toxin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in acetylcholine transport	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in amine transport	IEA Inferred from Electronic Annotation more info
involved_in amine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in choline transport	IEA Inferred from Electronic Annotation more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in dopamine uptake	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in histamine uptake	IEA Inferred from Electronic Annotation more info
involved_in histamine uptake	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in norepinephrine uptake	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within organic cation transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in putrescine transport	ISO Inferred from Sequence Orthology more info
involved_in putrescine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in quaternary ammonium group transport	IEA Inferred from Electronic Annotation more info
involved_in quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in thiamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 22 member 2

Names: organic cation transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355767.1 → NP_001342696.1 solute carrier family 22 member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC167817, AK052658, AK143892

Consensus CDS

CCDS88992.1

Related

ENSMUSP00000156710.2, ENSMUST00000233066.2

Conserved Domains (1) summary

TIGR00898
Location:12 → 525

2A0119; cation transport protein
NM_013667.3 → NP_038695.1 solute carrier family 22 member 2 isoform 1

See identical proteins and their annotated locations for NP_038695.1

Status: VALIDATED

Source sequence(s)

AC167817, AK052658, AK143892, BB739804

Consensus CDS

CCDS28392.1

UniProtKB/Swiss-Prot

O70577, Q8BWF6, Q8K4X8

Related

ENSMUSP00000041186.8, ENSMUST00000046959.9

Conserved Domains (2) summary

cd06174
Location:125 → 492

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 525

2A0119; cation transport protein