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    Nyap2 neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 241134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nyap2provided by MGI
    Official Full Name
    neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2provided by MGI
    Primary source
    MGI:MGI:2443135
    See related
    Ensembl:ENSMUSG00000054976 AllianceGenome:MGI:2443135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jr6; Kiaa1486; 9430031J16Rik
    Summary
    Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Is expressed in cortical plate. Orthologous to human NYAP2 (neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.9), cortex adult (RPKM 1.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nyap2 in Genome Data Viewer
    Location:
    1 C5; 1 41.75 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (81054239..81345438)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (81076522..81367706)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700016L21 gene Neighboring gene predicted gene, 38673 Neighboring gene dedicator of cytokinesis 10 Neighboring gene STARR-seq mESC enhancer starr_01461 Neighboring gene STARR-positive B cell enhancer ABC_E10018 Neighboring gene STARR-positive B cell enhancer mm9_chr1:80743907-80744208 Neighboring gene STARR-seq mESC enhancer starr_01462 Neighboring gene STARR-seq mESC enhancer starr_01463 Neighboring gene STARR-seq mESC enhancer starr_01464 Neighboring gene STARR-seq mESC enhancer starr_01465 Neighboring gene STARR-seq mESC enhancer starr_01466 Neighboring gene STARR-seq mESC enhancer starr_01467 Neighboring gene STARR-seq mESC enhancer starr_01469 Neighboring gene R3H domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01470 Neighboring gene STARR-seq mESC enhancer starr_01471 Neighboring gene STARR-seq mESC enhancer starr_01473 Neighboring gene phospholipid scramblase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Boettger-Tong HL, et al. Biochem Biophys Res Commun, 2001 Nov 16. PMID 11700028
    2. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Steinmetz CC, et al. Cell Rep, 2016 Sep 6. PMID 27568566, Free PMC Article
    3. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article
    4. Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Catela C, et al. Elife, 2022 Mar 22. PMID 35315772, Free PMC Article
    5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90544

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    Names
    neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356397.1 → NP_001343326.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116105, AC131336, AC163450
      Consensus CDS
      CCDS87851.1
      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      UniProtKB/TrEMBL
      A0A0R4J1X0
      Related
      ENSMUSP00000122935.2, ENSMUST00000123285.2
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 428
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:469 → 716
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. NM_001356398.1 → NP_001343327.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116105, AC131336
      Consensus CDS
      CCDS87853.1
      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      UniProtKB/TrEMBL
      D3Z3N9
      Related
      ENSMUSP00000117661.2, ENSMUST00000123720.8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 460
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:502 → 674
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    3. NM_001356399.1 → NP_001343328.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116105, AC131336
      Consensus CDS
      CCDS87852.1
      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      UniProtKB/TrEMBL
      A0A0R4J1I8
      Related
      ENSMUSP00000120767.2, ENSMUST00000137862.8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 428
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:470 → 642
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    4. NM_001356400.1 → NP_001343329.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116105, AC131336
      Consensus CDS
      CCDS87852.1
      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      UniProtKB/TrEMBL
      A0A0R4J1I8
      Related
      ENSMUSP00000109122.3, ENSMUST00000113494.9
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 428
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:470 → 642
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      81054239..81345438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496485.4 → XP_006496548.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X1

      See identical proteins and their annotated locations for XP_006496548.1

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 460
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:501 → 748
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. XM_030254174.1 → XP_030110034.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X3

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      UniProtKB/TrEMBL
      A0A0R4J1X0
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 428
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:469 → 716
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    3. XM_006496486.4 → XP_006496549.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X1

      See identical proteins and their annotated locations for XP_006496549.1

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 460
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:501 → 748
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    4. XM_030254176.1 → XP_030110036.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X3

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      UniProtKB/TrEMBL
      A0A0R4J1X0
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 428
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:469 → 716
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    5. XM_030254180.2 → XP_030110040.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X5

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 428
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:469 → 642
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    6. XM_006496488.5 → XP_006496551.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X4

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 460
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:501 → 674
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    7. XM_036165022.1 → XP_036020915.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X2

      UniProtKB/Swiss-Prot
      D3Z7K6, Q641L6, Q6ZPP8, Q8BM65, Q8BWV8
      Conserved Domains (2) summary
      pfam15439
      Location:56 → 474
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:501 → 678
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172849.3: Suppressed sequence

      Description
      NM_172849.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM65.1 GenPept UniProtKB/Swiss-Prot:Q8BM65

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