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    MICU1 Mitochondrial calcium uptake 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MICU1provided by FlyBase
    Official Full Name
    Mitochondrial calcium uptake 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031893
    Locus tag
    Dmel_CG4495
    See related
    AllianceGenome:FB:FBgn0031893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4495; Dmel\CG4495; micu1
    Summary
    Predicted to enable calcium ion binding activity. Involved in anesthesia-resistant memory; calcium import into the mitochondrion; and medium-term memory. Predicted to be part of uniplex complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and mesoderm. Used to study myopathy with extrapyramidal signs. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See MICU1 in Genome Data Viewer
    Location:
    27E4-27E4; 2-25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7182234..7185529)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7182234..7185529)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46210 Neighboring gene long non-coding RNA:CR44613 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of mitochondrial calcium uptake 1 in Drosophila neurons. M'Angale PG, et al. Genet Mol Res, 2017 Feb 8. PMID 28198506
    2. Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila. Drago I, et al. Cell Rep, 2016 Sep 6. PMID 27568554, Free PMC Article
    3. Parallel adaptive feedback enhances reliability of the Ca2+ signaling system. Abell E, et al. Proc Natl Acad Sci U S A, 2011 Aug 30. PMID 21844332, Free PMC Article
    4. Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo. Tufi R, et al. Cell Rep, 2019 Apr 30. PMID 31042479, Free PMC Article
    5. Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression. Pareek G, et al. PLoS Genet, 2020 Oct. PMID 33075064, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MICU1 mutants are developmentally lethal, consistent with unregulated Ca2+ uptake.
      Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in anesthesia-resistant memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium import into the mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of uniplex complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of uniplex complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial calcium uptake 1
    Names
    CG4495-PA
    CG4495-PB
    MICU1-PA
    MICU1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7182234..7185529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103640.2 → NP_001097110.1  mitochondrial calcium uptake 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEI2, Q9VM38
      Conserved Domains (2) summary
      pfam13833
      Location:438 → 491
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:252 → 293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_135256.3 → NP_609100.1  mitochondrial calcium uptake 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEI2
      Related
      FBpp0079033
      Conserved Domains (2) summary
      pfam13833
      Location:437 → 490
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:251 → 292
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VEI2.1 A2VEI2

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