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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851473, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000007588
    Locus tag
    YDL085C-A
    See related
    AllianceGenome:SGD:S000007588; FungiDB:YDL085C-A; VEuPathDB:YDL085C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in cytoplasm and nucleus. Used to study neurodegenerative disease. Orthologous to several human genes including SERF2 (small EDRK-rich factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (302464..302670, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Luc7p Neighboring gene carboxymethylenebutenolidase Neighboring gene NADH-ubiquinone reductase (H(+)-translocating) NDE2 Neighboring gene ATP-dependent RNA helicase SUB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Backbone resonance assignments and dynamics of S. cerevisiae SERF. Liu Y, et al. Biomol NMR Assign, 2022 Oct. PMID 35713792
    2. SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins. Meinen BA, et al. Proc Natl Acad Sci U S A, 2019 Nov 12. PMID 31659041, Free PMC Article
    3. Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast. Mirisola MG, et al. Biomed J, 2024 Apr. PMID 38154617, Free PMC Article
    4. Global identification of new substrates for the yeast endoribonuclease, RNase mitochondrial RNA processing (MRP). Aulds J, et al. J Biol Chem, 2012 Oct 26. PMID 22977255, Free PMC Article
    5. Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications. Nitika, et al. PLoS Biol, 2022 Oct. PMID 36269765, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Backbone resonance assignments and dynamics of S. cerevisiae SERF.
      Title: Backbone resonance assignments and dynamics of S. cerevisiae SERF.
    2. SERF(YDL085C-A) mainly affects the rate of primary nucleation in amyloid formation for the disease-related proteins Abeta40 and alpha-synuclein.
      Title: SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_075208.1
    • Homolog of modifier of aggregation-4 (MOAG-4) from worm and small EDRK-rich factor protein (SERF1a) from human; highly conserved enhancer of amyloid formation of Abeta40 and alpha-synuclein both in vitro and in vivo; protein displays very high degree of disorder, segment spanning residues 36E-65K has strong helical propensity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      302464..302670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184455.1 → NP_075208.1  TPA: uncharacterized protein YDL085C-A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_075208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRR3, Q3E7B7
      UniProtKB/TrEMBL
      A6ZXP2, B3LGY0, C7GJM8, G2WC77, N1P7P3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E7B7.1

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