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    vps-8 Vacuolar protein sorting-associated protein 8 central domain-containing protein;Vps8 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178174, updated on 2-Nov-2024

    Summary

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    Official Symbol
    vps-8
    Official Full Name
    Vacuolar protein sorting-associated protein 8 central domain-containing protein;Vps8 domain-containing protein
    Primary source
    WormBase:WBGene00016582
    Locus tag
    CELE_C42C1.4
    See related
    AllianceGenome:WB:WBGene00016582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endosomal vesicle fusion and protein targeting to vacuole. Predicted to be part of HOPS complex. Predicted to be active in late endosome. Is expressed in intestine; nervous system; and rectal gland cell. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See vps-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (12270490..12275992, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL34 Neighboring gene Ovule protein Neighboring gene Mannose-1-phosphate guanylyltransferase catalytic subunit beta Neighboring gene Protein-lysine methyltransferase C42C1.13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endosomal vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 8 central domain-containing protein;Vps8 domain-containing protein
    NP_001023059.1
    • Confirmed by transcript evidence
    NP_001293991.1
    • Confirmed by transcript evidence
    NP_001293992.1
    • Confirmed by transcript evidence
    NP_001359706.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12270490..12275992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027888.5 → NP_001023059.1  Vps8 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3QMB3
      Conserved Domains (2) summary
      pfam12816
      Location:549 → 727
      Vps8; Golgi CORVET complex core vacuolar protein 8
      pfam12894
      Location:110 → 176
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain

    2. NM_001307062.3 → NP_001293991.1  Vacuolar protein sorting-associated protein 8 central domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD29
      Conserved Domains (1) summary
      pfam12816
      Location:412 → 590
      Vps8; Golgi CORVET complex core vacuolar protein 8

    3. NM_001307063.3 → NP_001293992.1  Vps8 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AE89

    4. NM_001372932.3 → NP_001359706.1  Vps8 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3QMB4
    Nucleotide Protein
    Heading Accession and Version

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