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    Anapc10 anaphase promoting complex subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 68999, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Anapc10provided by MGI
    Official Full Name
    anaphase promoting complex subunit 10provided by MGI
    Primary source
    MGI:MGI:1916249
    See related
    Ensembl:ENSMUSG00000036977 AllianceGenome:MGI:1916249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC10; 1500026N15Rik; A830003M23Rik
    Summary
    Predicted to be involved in anaphase-promoting complex-dependent catabolic process and protein polyubiquitination. Located in cytoplasm. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), CNS E14 (RPKM 2.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anapc10 in Genome Data Viewer
    Location:
    8 C1; 8 37.79 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80438366..80503950)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79711736..79777321)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51579 Neighboring gene OTU domain containing 4 Neighboring gene tumor protein D52, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9318 Neighboring gene STARR-seq mESC enhancer starr_22015 Neighboring gene ATP-binding cassette, sub-family E member 1 Neighboring gene STARR-seq mESC enhancer starr_22017 Neighboring gene STARR-positive B cell enhancer ABC_E9118 Neighboring gene STARR-seq mESC enhancer starr_22019 Neighboring gene STARR-seq mESC enhancer starr_22022 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 30494 Neighboring gene STARR-seq mESC enhancer starr_22024 Neighboring gene STARR-seq mESC enhancer starr_22025 Neighboring gene STARR-seq mESC enhancer starr_22026 Neighboring gene Hedgehog-interacting protein Neighboring gene predicted gene, 39206

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Zhao S, et al. Dev Cell, 2013 Jan 14. PMID 23328397
    2. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Ray D, et al. Biol Reprod, 2012 Apr. PMID 22190705, Free PMC Article
    3. Oligosyndactylism mice have an inversion of chromosome 8. Wise TL, et al. Genetics, 2004 Dec. PMID 15611179, Free PMC Article
    4. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. Shoji S, et al. FEBS Open Bio, 2014. PMID 25161877, Free PMC Article
    5. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. Saito K, et al. iScience, 2020 Jul 24. PMID 32674056, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANAPC10 was mainly expressed in the cytoplasm of spermatogonia and leptotene and pachytene spermatocytes.
      Title: Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of anaphase-promoting complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 10
    Names
    cyclosome subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357234.1 → NP_001344163.1  anaphase-promoting complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, BB647573
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q8K2H6, Q9CW24
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    2. NM_001357235.1 → NP_001344164.1  anaphase-promoting complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, AK041373
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q8K2H6, Q9CW24
      Related
      ENSMUSP00000148220.2, ENSMUST00000210812.2
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    3. NM_001357236.1 → NP_001344165.1  anaphase-promoting complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, BQ178177
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q8K2H6, Q9CW24
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    4. NM_001357237.1 → NP_001344166.1  anaphase-promoting complex subunit 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, BE863817
      Conserved Domains (1) summary
      cl02148
      Location:4 → 111
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    5. NM_026904.3 → NP_081180.1  anaphase-promoting complex subunit 10 isoform a

      See identical proteins and their annotated locations for NP_081180.1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, AK005303, CX567202
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q8K2H6, Q9CW24
      Related
      ENSMUSP00000048244.8, ENSMUST00000048147.9
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      80438366..80503950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243749.2 → XP_030099609.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    2. XM_006531342.2 → XP_006531405.1  anaphase-promoting complex subunit 10 isoform X2

      See identical proteins and their annotated locations for XP_006531405.1

      Conserved Domains (1) summary
      cl02148
      Location:4 → 111
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    3. XM_030243751.1 → XP_030099611.1  anaphase-promoting complex subunit 10 isoform X3

      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    4. XM_036154264.1 → XP_036010157.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    5. XM_036154266.1 → XP_036010159.1  anaphase-promoting complex subunit 10 isoform X3

      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    6. XM_036154265.1 → XP_036010158.1  anaphase-promoting complex subunit 10 isoform X2

      Conserved Domains (1) summary
      cl02148
      Location:4 → 111
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    7. XM_030243750.1 → XP_030099610.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2H6.1 GenPept UniProtKB/Swiss-Prot:Q8K2H6

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