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    Plcd4 phospholipase C, delta 4 [ Mus musculus (house mouse) ]

    Gene ID: 18802, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plcd4provided by MGI
    Official Full Name
    phospholipase C, delta 4provided by MGI
    Primary source
    MGI:MGI:107469
    See related
    Ensembl:ENSMUSG00000026173 AllianceGenome:MGI:107469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921507K24Rik
    Summary
    Predicted to enable G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol phospholipase C activity. Acts upstream of or within acrosome reaction. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in plasma membrane. Is expressed in male reproductive gland or organ and nervous system. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 22.6), cerebellum adult (RPKM 4.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plcd4 in Genome Data Viewer
    Location:
    1 C4; 1 38.54 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74581175..74605137)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74541975..74565977)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene zinc finger protein 142 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Growth factor-induced promoter activation of murine phospholipase C delta4 gene. Fukami K, et al. Eur J Biochem, 2000 Jan. PMID 10601847
    2. Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C. Akutagawa A, et al. J Biochem, 2006 Nov. PMID 16998201
    3. Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. Fukami K, et al. J Cell Biol, 2003 Apr 14. PMID 12695499, Free PMC Article
    4. Phospholipase Cdelta4: from genome structure to physiological function. Fukami K, et al. Adv Enzyme Regul, 2003. PMID 12791385
    5. Phospholipase C δ4 regulates cold sensitivity in mice. Yudin Y, et al. J Physiol, 2016 Jul 1. PMID 27062607, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We identify PLCdelta4 as a PLC isoform important in the regulation of TRPM8 both at the cellular level and in vivo
      Title: Phospholipase C δ4 regulates cold sensitivity in mice.
    2. These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
      Title: Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.
    3. PLCd4 is required for the acrosome reaction in fertilization.
      Title: Physiological functions of phospholipase C delta-type.
    4. PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal
      Title: The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.
    5. PLCd4 has a role in the zona pellucida-induced acrosome reaction in mice
      Title: Phospholipase Cdelta4: from genome structure to physiological function.
    6. It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha and epsilon
      Title: Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase C activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Names
    PLC-delta-4
    phosphoinositide phospholipase C-delta-4
    NP_001074925.1
    NP_683739.2
    XP_006495846.1
    XP_006495847.1
    XP_006495848.1
    XP_006495850.1
    XP_006495851.1
    XP_006495852.1
    XP_017174835.1
    XP_036018673.1
    XP_036018674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081456.1 → NP_001074925.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35617.1
      UniProtKB/Swiss-Prot
      Q8K3R3
      Related
      ENSMUSP00000109376.2, ENSMUST00000113747.8
      Conserved Domains (8) summary
      cd00275
      Location:639 → 764
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02228
      Location:207 → 752
      PLN02228; Phosphoinositide phospholipase C
      pfam00169
      Location:17 → 123
      PH; PH domain
      pfam09279
      Location:207 → 289
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:143 → 199
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 609
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    2. NM_148937.2 → NP_683739.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2

      See identical proteins and their annotated locations for NP_683739.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is longer but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35616.1
      UniProtKB/Swiss-Prot
      Q3USN9, Q6NZF7, Q8CAB1, Q8K3R3, Q9CUC1
      Related
      ENSMUSP00000027362.8, ENSMUST00000027362.14
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 784
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74581175..74605137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495787.5 → XP_006495850.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 772
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18 → 133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 640
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. XM_006495785.5 → XP_006495848.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006495848.1

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 773
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18 → 133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    3. XM_006495783.5 → XP_006495846.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006495846.1

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 773
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18 → 133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    4. XM_036162781.1 → XP_036018674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 740
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 608
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    5. XM_036162780.1 → XP_036018673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 783
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 640
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    6. XM_006495789.5 → XP_006495852.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 741
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 609
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    7. XM_006495788.5 → XP_006495851.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3

      See identical proteins and their annotated locations for XP_006495851.1

      UniProtKB/Swiss-Prot
      Q3USN9, Q6NZF7, Q8CAB1, Q8K3R3, Q9CUC1
      Conserved Domains (4) summary
      PLN02228
      Location:207 → 784
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    8. XM_017319346.3 → XP_017174835.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 751
      PLN02228; Phosphoinositide phospholipase C
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 608
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:18 → 133
      PH-like; Pleckstrin homology-like domain

    9. XM_006495784.5 → XP_006495847.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

      See identical proteins and their annotated locations for XP_006495847.1

      Conserved Domains (4) summary
      PLN02228
      Location:207 → 773
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:18 → 133
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:153 → 202
      EF-hand_10; EF hand
      cl14615
      Location:289 → 641
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RNA

    1. XR_865222.4 RNA Sequence

    2. XR_001783208.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3R3.2 GenPept UniProtKB/Swiss-Prot:Q8K3R3

    Gene LinkOut

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